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01.09.2011 | Außer der Reihe

Psychoneuroimmunologie und Krebs

Neue Ergebnisse zu psychosozialen Einflüssen auf Tumorerkrankungen

verfasst von: Dr. J. Hefner, H. Csef

Erschienen in: Die Onkologie | Ausgabe 9/2011

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Zusammenfassung

Aktuelle Arbeiten deuten auf einen Einfluss psychischer Faktoren auf den Krankheitsverlauf bei Krebs hin. Bei der Suche nach den zugrunde liegenden Mechanismen konzentrierte sich die psychoneuroimmunologische Forschung auf den Einfluss von psychischer Belastung bzw. von Stresshormonen auf die Wechselwirkungen von Immunsystem und Tumorzelle. Dabei wurden natürliche Killer (NK)-Zellen bisher am umfangreichsten untersucht. Doch die Ergebnisse sind inkonsistent, und so führte dies – in Anlehnung an die onkologische Forschung – zu einer Verschiebung des Fokus hin zu Untersuchungen des „tumor microenvironment“. Hier wurden in den letzten Jahren zu einzelnen Tumorentitäten neue Erkenntnisse gewonnen, die durch Gemeinsamkeiten der Pathophysiologie auch für die Onkologie bedeutsam sind. Weiterhin unklar bleibt dabei die Relevanz der Befunde für den Krankheitsverlauf bei Krebs.
Literatur
1.
Zurück zum Zitat Ader R, Cohen N (1975) Behaviorally conditioned immunosuppression. Psychosom Med 37:333–340PubMed Ader R, Cohen N (1975) Behaviorally conditioned immunosuppression. Psychosom Med 37:333–340PubMed
2.
Zurück zum Zitat Akaho R et al (2003) Psychological factors and survival after bone marrow transplantation in patients with leukemia. Psychiatry Clin Neurosci 57:91–96PubMedCrossRef Akaho R et al (2003) Psychological factors and survival after bone marrow transplantation in patients with leukemia. Psychiatry Clin Neurosci 57:91–96PubMedCrossRef
3.
Zurück zum Zitat Alesci S et al (2005) Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications. J Clin Endocrinol Metab 90:2522–2530PubMedCrossRef Alesci S et al (2005) Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications. J Clin Endocrinol Metab 90:2522–2530PubMedCrossRef
4.
Zurück zum Zitat Andersen BL et al (1998) Stress and immune responses after surgical treatment for regional breast cancer. J Natl Cancer Inst 90:30–36PubMedCrossRef Andersen BL et al (1998) Stress and immune responses after surgical treatment for regional breast cancer. J Natl Cancer Inst 90:30–36PubMedCrossRef
5.
Zurück zum Zitat Andersen BL et al (2008) Psychologic intervention improves survival for breast cancer patients: a randomized clinical trial. Cancer 113:3450–3458PubMedCrossRef Andersen BL et al (2008) Psychologic intervention improves survival for breast cancer patients: a randomized clinical trial. Cancer 113:3450–3458PubMedCrossRef
6.
Zurück zum Zitat Andrykowski MA (2005) Depression and survival after hematopoietic stem cell transplantation: where do we go from here? J Clin Oncol 23:5878–5880PubMedCrossRef Andrykowski MA (2005) Depression and survival after hematopoietic stem cell transplantation: where do we go from here? J Clin Oncol 23:5878–5880PubMedCrossRef
7.
Zurück zum Zitat Andrykowski MA, Brady MJ, Henslee-Downey PJ (1994) Psychosocial factors predictive of survival after allogeneic bone marrow transplantation for leukemia. Psychosom Med 56:432–439PubMed Andrykowski MA, Brady MJ, Henslee-Downey PJ (1994) Psychosocial factors predictive of survival after allogeneic bone marrow transplantation for leukemia. Psychosom Med 56:432–439PubMed
8.
Zurück zum Zitat Badino GR et al (1996) Evidence for functional beta-adrenoceptor subtypes in CG-5 breast cancer cell. Pharmacol Res 33:255–260PubMedCrossRef Badino GR et al (1996) Evidence for functional beta-adrenoceptor subtypes in CG-5 breast cancer cell. Pharmacol Res 33:255–260PubMedCrossRef
9.
10.
Zurück zum Zitat Baxevanis CN et al (1993) Elevated prostaglandin E2 production by monocytes is responsible for the depressed levels of natural killer and lymphokine-activated killer cell function in patients with breast cancer. Cancer 72:491–501PubMedCrossRef Baxevanis CN et al (1993) Elevated prostaglandin E2 production by monocytes is responsible for the depressed levels of natural killer and lymphokine-activated killer cell function in patients with breast cancer. Cancer 72:491–501PubMedCrossRef
11.
Zurück zum Zitat Ben-Eliyahu S, Page GG, Schleifer SJ (2007) Stress, NK cells, and cancer: still a promissory note. Brain Behav Immun 21:881–887PubMedCrossRef Ben-Eliyahu S, Page GG, Schleifer SJ (2007) Stress, NK cells, and cancer: still a promissory note. Brain Behav Immun 21:881–887PubMedCrossRef
12.
Zurück zum Zitat Benish M et al (2008) Perioperative use of beta-blockers and COX-2 inhibitors may improve immune competence and reduce the risk of tumor metastasis. Ann Surg Oncol 15:2042–2052PubMedCrossRef Benish M et al (2008) Perioperative use of beta-blockers and COX-2 inhibitors may improve immune competence and reduce the risk of tumor metastasis. Ann Surg Oncol 15:2042–2052PubMedCrossRef
13.
Zurück zum Zitat Benjamin JE, Gill S, Negrin RS (2010) Biology and clinical effects of natural killer cells in allogeneic transplantation. Curr Opin Oncol 22:130–137PubMedCrossRef Benjamin JE, Gill S, Negrin RS (2010) Biology and clinical effects of natural killer cells in allogeneic transplantation. Curr Opin Oncol 22:130–137PubMedCrossRef
14.
Zurück zum Zitat Bierhaus A et al (2003) A mechanism converting psychosocial stress into mononuclear cell activation. Proc Natl Acad Sci USA 100:1920–1925PubMedCrossRef Bierhaus A et al (2003) A mechanism converting psychosocial stress into mononuclear cell activation. Proc Natl Acad Sci USA 100:1920–1925PubMedCrossRef
15.
Zurück zum Zitat Blomberg BB et al (2009) Psychosocial adaptation and cellular immunity in breast cancer patients in the weeks after surgery: an exploratory study. J Psychosom Res 67:369–376PubMedCrossRef Blomberg BB et al (2009) Psychosocial adaptation and cellular immunity in breast cancer patients in the weeks after surgery: an exploratory study. J Psychosom Res 67:369–376PubMedCrossRef
16.
Zurück zum Zitat Blume J, Douglas SD, Evans DL (2011) Immune suppression and immune activation in depression. Brain Behav Immun 25:221–229PubMedCrossRef Blume J, Douglas SD, Evans DL (2011) Immune suppression and immune activation in depression. Brain Behav Immun 25:221–229PubMedCrossRef
17.
Zurück zum Zitat Boesen EH et al (2007) Survival after a psychoeducational intervention for patients with cutaneous malignant melanoma: a replication study. J Clin Oncol 25:5698–5703PubMedCrossRef Boesen EH et al (2007) Survival after a psychoeducational intervention for patients with cutaneous malignant melanoma: a replication study. J Clin Oncol 25:5698–5703PubMedCrossRef
18.
Zurück zum Zitat Broers S et al (1998) Are pretransplant psychological variables related to survival after bone marrow transplantation? A prospective study of 123 consecutive patients. J Psychosom Res 45:341–351PubMedCrossRef Broers S et al (1998) Are pretransplant psychological variables related to survival after bone marrow transplantation? A prospective study of 123 consecutive patients. J Psychosom Res 45:341–351PubMedCrossRef
19.
Zurück zum Zitat Buddeberg C, Buddeberg-Fischer B, Schnyder U (1997) Coping strategies and 10-year outcome in early breast cancer. J Psychosom Res 43:625–626PubMedCrossRef Buddeberg C, Buddeberg-Fischer B, Schnyder U (1997) Coping strategies and 10-year outcome in early breast cancer. J Psychosom Res 43:625–626PubMedCrossRef
20.
Zurück zum Zitat Burnet FM (1970) The concept of immunological surveillance. Prog Exp Tumor Res 13:1–27PubMed Burnet FM (1970) The concept of immunological surveillance. Prog Exp Tumor Res 13:1–27PubMed
21.
Zurück zum Zitat Butow PN, Coates AS, Dunn SM (2000) Psychosocial predictors of survival: metastatic breast cancer. Ann Oncol 11:469–474PubMedCrossRef Butow PN, Coates AS, Dunn SM (2000) Psychosocial predictors of survival: metastatic breast cancer. Ann Oncol 11:469–474PubMedCrossRef
22.
Zurück zum Zitat Carbone E et al (2005) HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells. Blood 105:251–258PubMedCrossRef Carbone E et al (2005) HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells. Blood 105:251–258PubMedCrossRef
23.
Zurück zum Zitat Carie AE, Sebti SM (2007) A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1/Mek-1/Erk1/2 pathway. Oncogene 26:3777–3788PubMedCrossRef Carie AE, Sebti SM (2007) A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1/Mek-1/Erk1/2 pathway. Oncogene 26:3777–3788PubMedCrossRef
24.
Zurück zum Zitat Chan AS et al (2007) Dopaminergic and adrenergic toxicities on SK-N-MC human neuroblastoma cells are mediated through G protein signaling and oxidative stress. Apoptosis 12:167–179PubMedCrossRef Chan AS et al (2007) Dopaminergic and adrenergic toxicities on SK-N-MC human neuroblastoma cells are mediated through G protein signaling and oxidative stress. Apoptosis 12:167–179PubMedCrossRef
25.
Zurück zum Zitat Chang G et al (2004) Predictors of 1-year survival assessed at the time of bone marrow transplantation. Psychosomatics 45:378–385PubMedCrossRef Chang G et al (2004) Predictors of 1-year survival assessed at the time of bone marrow transplantation. Psychosomatics 45:378–385PubMedCrossRef
26.
Zurück zum Zitat Chen ML, Chen MC, Yu CT (2010) Depressive symptoms during the first chemotherapy cycle predict mortality in patients with advanced non-small cell lung cancer. Support Care Cancer, doi 10.1007/s00520-010-1005-8 Chen ML, Chen MC, Yu CT (2010) Depressive symptoms during the first chemotherapy cycle predict mortality in patients with advanced non-small cell lung cancer. Support Care Cancer, doi 10.1007/s00520-010-1005-8
28.
Zurück zum Zitat Costanzo ES et al (2005) Psychosocial factors and interleukin-6 among women with advanced ovarian cancer. Cancer 104:305–313PubMedCrossRef Costanzo ES et al (2005) Psychosocial factors and interleukin-6 among women with advanced ovarian cancer. Cancer 104:305–313PubMedCrossRef
29.
Zurück zum Zitat Dantzer R et al (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9:46–56PubMedCrossRef Dantzer R et al (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9:46–56PubMedCrossRef
30.
Zurück zum Zitat De Brabander B, Gerits P (1999) Chronic and acute stress as predictors of relapse in primary breast cancer patients. Patient Educ Couns 37:265–272CrossRef De Brabander B, Gerits P (1999) Chronic and acute stress as predictors of relapse in primary breast cancer patients. Patient Educ Couns 37:265–272CrossRef
31.
Zurück zum Zitat Dean C, Surtees PG (1989) Do psychological factors predict survival in breast cancer? J Psychosom Res 33:561–569PubMedCrossRef Dean C, Surtees PG (1989) Do psychological factors predict survival in breast cancer? J Psychosom Res 33:561–569PubMedCrossRef
32.
Zurück zum Zitat Derogatis LR, Abeloff MD, Melisaratos N (1979) Psychological coping mechanisms and survival time in metastatic breast cancer. JAMA 242:1504–1508PubMedCrossRef Derogatis LR, Abeloff MD, Melisaratos N (1979) Psychological coping mechanisms and survival time in metastatic breast cancer. JAMA 242:1504–1508PubMedCrossRef
33.
Zurück zum Zitat Dhodapkar MV et al (2003) A reversible defect in natural killer T cell function characterizes the progression of premalignant to malignant multiple myeloma. J Exp Med 197:1667–1676PubMedCrossRef Dhodapkar MV et al (2003) A reversible defect in natural killer T cell function characterizes the progression of premalignant to malignant multiple myeloma. J Exp Med 197:1667–1676PubMedCrossRef
34.
Zurück zum Zitat Disis ML, Lyerly HK (2005) Global role of the immune system in identifying cancer initiation and limiting disease progression. J Clin Oncol 23:8923–8925PubMedCrossRef Disis ML, Lyerly HK (2005) Global role of the immune system in identifying cancer initiation and limiting disease progression. J Clin Oncol 23:8923–8925PubMedCrossRef
35.
Zurück zum Zitat Dong HP et al (2006) NK- and B-cell infiltration correlates with worse outcome in metastatic ovarian carcinoma. Am J Clin Pathol 125:451–458PubMed Dong HP et al (2006) NK- and B-cell infiltration correlates with worse outcome in metastatic ovarian carcinoma. Am J Clin Pathol 125:451–458PubMed
36.
Zurück zum Zitat Drell TL et al (2003) Effects of neurotransmitters on the chemokinesis and chemotaxis of MDA-MB-468 human breast carcinoma cells. Breast Cancer Res Treat 80:63–70PubMedCrossRef Drell TL et al (2003) Effects of neurotransmitters on the chemokinesis and chemotaxis of MDA-MB-468 human breast carcinoma cells. Breast Cancer Res Treat 80:63–70PubMedCrossRef
37.
Zurück zum Zitat Duan Z et al (2006) Signal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancer. Clin Cancer Res 12:5055–5063PubMedCrossRef Duan Z et al (2006) Signal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancer. Clin Cancer Res 12:5055–5063PubMedCrossRef
38.
Zurück zum Zitat Enserink JM et al (2004) The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin. J Biol Chem 279:44889–44896PubMedCrossRef Enserink JM et al (2004) The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin. J Biol Chem 279:44889–44896PubMedCrossRef
39.
Zurück zum Zitat Forsen A (1991) Psychosocial stress as a risk for breast cancer. Psychother Psychosom 55:176–185PubMedCrossRef Forsen A (1991) Psychosocial stress as a risk for breast cancer. Psychother Psychosom 55:176–185PubMedCrossRef
40.
Zurück zum Zitat Fredriksson JM et al (2000) Norepinephrine induces vascular endothelial growth factor gene expression in brown adipocytes through a beta-adrenoreceptor/cAMP/protein kinase A pathway involving Src but independently of Erk1/2. J Biol Chem 275:13802–13811PubMedCrossRef Fredriksson JM et al (2000) Norepinephrine induces vascular endothelial growth factor gene expression in brown adipocytes through a beta-adrenoreceptor/cAMP/protein kinase A pathway involving Src but independently of Erk1/2. J Biol Chem 275:13802–13811PubMedCrossRef
41.
Zurück zum Zitat Frick E et al (2005) Is perceived social support a predictor of survival for patients undergoing autologous peripheral blood stem cell transplantation? Psychooncology 14:759–770PubMedCrossRef Frick E et al (2005) Is perceived social support a predictor of survival for patients undergoing autologous peripheral blood stem cell transplantation? Psychooncology 14:759–770PubMedCrossRef
42.
Zurück zum Zitat Funch DP, Marshall J (1983) The role of stress, social support and age in survival from breast cancer. J Psychosom Res 27:77–83PubMedCrossRef Funch DP, Marshall J (1983) The role of stress, social support and age in survival from breast cancer. J Psychosom Res 27:77–83PubMedCrossRef
43.
Zurück zum Zitat Gilbar O (1996) The connection between the psychological condition of breast cancer patients and survival. A follow-up after eight years. Gen Hosp Psychiatry 18:266–270PubMedCrossRef Gilbar O (1996) The connection between the psychological condition of breast cancer patients and survival. A follow-up after eight years. Gen Hosp Psychiatry 18:266–270PubMedCrossRef
44.
Zurück zum Zitat Giraldi T et al (1997) Psychosocial factors and breast cancer: a 6-year Italian follow-up study. Psychother Psychosom 66:229–236PubMedCrossRef Giraldi T et al (1997) Psychosocial factors and breast cancer: a 6-year Italian follow-up study. Psychother Psychosom 66:229–236PubMedCrossRef
45.
Zurück zum Zitat Glasner A et al (2010) Improving survival rates in two models of spontaneous postoperative metastasis in mice by combined administration of a beta-adrenergic antagonist and a cyclooxygenase-2 inhibitor. J Immunol 184:2449–2457PubMedCrossRef Glasner A et al (2010) Improving survival rates in two models of spontaneous postoperative metastasis in mice by combined administration of a beta-adrenergic antagonist and a cyclooxygenase-2 inhibitor. J Immunol 184:2449–2457PubMedCrossRef
46.
Zurück zum Zitat Goldberg JE, Schwertfeger KL (2010) Proinflammatory cytokines in breast cancer: mechanisms of action and potential targets for therapeutics. Curr Drug Targets 11:1133–1146PubMedCrossRef Goldberg JE, Schwertfeger KL (2010) Proinflammatory cytokines in breast cancer: mechanisms of action and potential targets for therapeutics. Curr Drug Targets 11:1133–1146PubMedCrossRef
47.
Zurück zum Zitat Goodwin PJ et al (2001) The effect of group psychosocial support on survival in metastatic breast cancer. N Engl J Med 345:1719–1726PubMedCrossRef Goodwin PJ et al (2001) The effect of group psychosocial support on survival in metastatic breast cancer. N Engl J Med 345:1719–1726PubMedCrossRef
48.
Zurück zum Zitat Greer S et al (1990) Psychological response to breast cancer and 15-year outcome. Lancet 335:49–50PubMedCrossRef Greer S et al (1990) Psychological response to breast cancer and 15-year outcome. Lancet 335:49–50PubMedCrossRef
49.
Zurück zum Zitat Herr I et al (2003) Glucocorticoid cotreatment induces apoptosis resistance toward cancer therapy in carcinomas. Cancer Res 63:3112–3120PubMed Herr I et al (2003) Glucocorticoid cotreatment induces apoptosis resistance toward cancer therapy in carcinomas. Cancer Res 63:3112–3120PubMed
50.
Zurück zum Zitat Hislop TG et al (1987) The prognostic significance of psychosocial factors in women with breast cancer. J Chronic Dis 40:729–735PubMedCrossRef Hislop TG et al (1987) The prognostic significance of psychosocial factors in women with breast cancer. J Chronic Dis 40:729–735PubMedCrossRef
51.
52.
Zurück zum Zitat Hong DS, Angelo LS, Kurzrock R (2007) Interleukin-6 and its receptor in cancer: implications for translational therapeutics. Cancer 110:1911–1928PubMedCrossRef Hong DS, Angelo LS, Kurzrock R (2007) Interleukin-6 and its receptor in cancer: implications for translational therapeutics. Cancer 110:1911–1928PubMedCrossRef
53.
Zurück zum Zitat Hoodin F et al (2004) Psychosocial influences on 305 adults‘ survival after bone marrow transplantation; depression, smoking, and behavioral self-regulation. J Psychosom Res 57:145–154PubMedCrossRef Hoodin F et al (2004) Psychosocial influences on 305 adults‘ survival after bone marrow transplantation; depression, smoking, and behavioral self-regulation. J Psychosom Res 57:145–154PubMedCrossRef
54.
Zurück zum Zitat Hoodin F et al (2006) Do negative or positive emotions differentially impact mortality after adult stem cell transplant? Bone Marrow Transplant 38:255–264PubMedCrossRef Hoodin F et al (2006) Do negative or positive emotions differentially impact mortality after adult stem cell transplant? Bone Marrow Transplant 38:255–264PubMedCrossRef
55.
Zurück zum Zitat Jamison RN, Burish TG, Wallston KA (1987) Psychogenic factors in predicting survival of breast cancer patients. J Clin Oncol 5:768–772PubMed Jamison RN, Burish TG, Wallston KA (1987) Psychogenic factors in predicting survival of breast cancer patients. J Clin Oncol 5:768–772PubMed
56.
Zurück zum Zitat Janknecht R et al (1996) The ETS-related transcription factor ERM is a nuclear target of signaling cascades involving MAPK and PKA. Oncogene 13:1745–1754PubMed Janknecht R et al (1996) The ETS-related transcription factor ERM is a nuclear target of signaling cascades involving MAPK and PKA. Oncogene 13:1745–1754PubMed
57.
58.
Zurück zum Zitat Jenkins PL et al (1994) A prospective study of psychosocial morbidity in adult bone marrow transplant recipients. Psychosomatics 35:361–367PubMed Jenkins PL et al (1994) A prospective study of psychosocial morbidity in adult bone marrow transplant recipients. Psychosomatics 35:361–367PubMed
59.
Zurück zum Zitat Jensen MR (1987) Psychobiological factors predicting the course of breast cancer. J Pers 55:317–342PubMedCrossRef Jensen MR (1987) Psychobiological factors predicting the course of breast cancer. J Pers 55:317–342PubMedCrossRef
60.
Zurück zum Zitat Kamat AA et al (2006) The clinical relevance of stromal matrix metalloproteinase expression in ovarian cancer. Clin Cancer Res 12:1707–1714PubMedCrossRef Kamat AA et al (2006) The clinical relevance of stromal matrix metalloproteinase expression in ovarian cancer. Clin Cancer Res 12:1707–1714PubMedCrossRef
61.
Zurück zum Zitat Konjevic G, Spuzic I (1993) Stage dependence of NK cell activity and its modulation by interleukin 2 in patients with breast cancer. Neoplasma 40:81–85PubMed Konjevic G, Spuzic I (1993) Stage dependence of NK cell activity and its modulation by interleukin 2 in patients with breast cancer. Neoplasma 40:81–85PubMed
62.
Zurück zum Zitat Kovaru H et al (2009) Cell signalling in CNS and immune system in depression and during antidepressant treatment: focus on glial and natural killer cells. Neuro Endocrinol Lett 30:421–428PubMed Kovaru H et al (2009) Cell signalling in CNS and immune system in depression and during antidepressant treatment: focus on glial and natural killer cells. Neuro Endocrinol Lett 30:421–428PubMed
63.
Zurück zum Zitat Kroenke CH et al (2006) Social networks, social support, and survival after breast cancer diagnosis. J Clin Oncol 24:1105–1111PubMedCrossRef Kroenke CH et al (2006) Social networks, social support, and survival after breast cancer diagnosis. J Clin Oncol 24:1105–1111PubMedCrossRef
64.
Zurück zum Zitat Lahdenpohja N, Henttinen T, Hurme M (1996) Activation of the protein kinase A increases the DNA-binding and transcriptional activity of c-Rel in T cells. Scand J Immunol 43:640–645PubMedCrossRef Lahdenpohja N, Henttinen T, Hurme M (1996) Activation of the protein kinase A increases the DNA-binding and transcriptional activity of c-Rel in T cells. Scand J Immunol 43:640–645PubMedCrossRef
65.
Zurück zum Zitat Landen CN Jr et al (2007) Neuroendocrine modulation of signal transducer and activator of transcription-3 in ovarian cancer. Cancer Res 67:10389–10396PubMedCrossRef Landen CN Jr et al (2007) Neuroendocrine modulation of signal transducer and activator of transcription-3 in ovarian cancer. Cancer Res 67:10389–10396PubMedCrossRef
66.
Zurück zum Zitat Lang K et al (2004) Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs. Int J Cancer 112:231–238PubMedCrossRef Lang K et al (2004) Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs. Int J Cancer 112:231–238PubMedCrossRef
67.
Zurück zum Zitat Lanquillon S et al (2000) Cytokine production and treatment response in major depressive disorder. Neuropsychopharmacology 22:370–379PubMedCrossRef Lanquillon S et al (2000) Cytokine production and treatment response in major depressive disorder. Neuropsychopharmacology 22:370–379PubMedCrossRef
68.
Zurück zum Zitat Lee SJ et al (2003) Optimistic expectations and survival after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 9:389–396PubMedCrossRef Lee SJ et al (2003) Optimistic expectations and survival after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 9:389–396PubMedCrossRef
69.
Zurück zum Zitat Levy S et al (1987) Correlation of stress factors with sustained depression of natural killer cell activity and predicted prognosis in patients with breast cancer. J Clin Oncol 5:348–353PubMed Levy S et al (1987) Correlation of stress factors with sustained depression of natural killer cell activity and predicted prognosis in patients with breast cancer. J Clin Oncol 5:348–353PubMed
70.
Zurück zum Zitat Levy SM et al (1991) Immunological and psychosocial predictors of disease recurrence in patients with early-stage breast cancer. Behav Med 17:67–75PubMedCrossRef Levy SM et al (1991) Immunological and psychosocial predictors of disease recurrence in patients with early-stage breast cancer. Behav Med 17:67–75PubMedCrossRef
71.
Zurück zum Zitat Levy SM et al (1985) Prognostic risk assessment in primary breast cancer by behavioral and immunological parameters. Health Psychol 4:99–113PubMedCrossRef Levy SM et al (1985) Prognostic risk assessment in primary breast cancer by behavioral and immunological parameters. Health Psychol 4:99–113PubMedCrossRef
72.
Zurück zum Zitat Levy SM et al (1988) Survival hazards analysis in first recurrent breast cancer patients: seven-year follow-up. Psychosom Med 50:520–528PubMed Levy SM et al (1988) Survival hazards analysis in first recurrent breast cancer patients: seven-year follow-up. Psychosom Med 50:520–528PubMed
73.
Zurück zum Zitat Loberiza FR Jr et al (2002) Association of depressive syndrome and early deaths among patients after stem-cell transplantation for malignant diseases. J Clin Oncol 20:2118–2126PubMedCrossRef Loberiza FR Jr et al (2002) Association of depressive syndrome and early deaths among patients after stem-cell transplantation for malignant diseases. J Clin Oncol 20:2118–2126PubMedCrossRef
74.
Zurück zum Zitat Lutgendorf SK et al (2003) Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines. Clin Cancer Res 9:4514–4521PubMed Lutgendorf SK et al (2003) Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines. Clin Cancer Res 9:4514–4521PubMed
75.
Zurück zum Zitat Lutgendorf SK et al (2009) Depression, social support, and beta-adrenergic transcription control in human ovarian cancer. Brain Behav Immun 23:176–183PubMedCrossRef Lutgendorf SK et al (2009) Depression, social support, and beta-adrenergic transcription control in human ovarian cancer. Brain Behav Immun 23:176–183PubMedCrossRef
76.
Zurück zum Zitat Lutgendorf SK et al (2002) Vascular endothelial growth factor and social support in patients with ovarian carcinoma. Cancer 95:808–815PubMedCrossRef Lutgendorf SK et al (2002) Vascular endothelial growth factor and social support in patients with ovarian carcinoma. Cancer 95:808–815PubMedCrossRef
77.
Zurück zum Zitat Lutgendorf SK et al (2008) Biobehavioral influences on matrix metalloproteinase expression in ovarian carcinoma. Clin Cancer Res 14:6839–6846PubMedCrossRef Lutgendorf SK et al (2008) Biobehavioral influences on matrix metalloproteinase expression in ovarian carcinoma. Clin Cancer Res 14:6839–6846PubMedCrossRef
78.
Zurück zum Zitat Lutgendorf SK et al (2005) Distress and expression of natural killer receptors on lymphocytes. Brain Behav Immun 19:185–194PubMedCrossRef Lutgendorf SK et al (2005) Distress and expression of natural killer receptors on lymphocytes. Brain Behav Immun 19:185–194PubMedCrossRef
79.
Zurück zum Zitat Lutgendorf SK et al (2005) Social support, psychological distress, and natural killer cell activity in ovarian cancer. J Clin Oncol 23:7105–7113PubMedCrossRef Lutgendorf SK et al (2005) Social support, psychological distress, and natural killer cell activity in ovarian cancer. J Clin Oncol 23:7105–7113PubMedCrossRef
80.
Zurück zum Zitat Lutgendorf SK et al (2008) Interleukin-6, cortisol, and depressive symptoms in ovarian cancer patients. J Clin Oncol 26:4820–4827PubMedCrossRef Lutgendorf SK et al (2008) Interleukin-6, cortisol, and depressive symptoms in ovarian cancer patients. J Clin Oncol 26:4820–4827PubMedCrossRef
81.
Zurück zum Zitat Luttrell LM et al (1999) Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science 283:655–661PubMedCrossRef Luttrell LM et al (1999) Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science 283:655–661PubMedCrossRef
82.
Zurück zum Zitat Machein MR et al (1999) Differential downregulation of vascular endothelial growth factor by dexamethasone in normoxic and hypoxic rat glioma cells. Neuropathol Appl Neurobiol 25:104–112PubMedCrossRef Machein MR et al (1999) Differential downregulation of vascular endothelial growth factor by dexamethasone in normoxic and hypoxic rat glioma cells. Neuropathol Appl Neurobiol 25:104–112PubMedCrossRef
83.
Zurück zum Zitat Maes M et al (1993) Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression. Psychiatry Res 49:11–27PubMedCrossRef Maes M et al (1993) Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression. Psychiatry Res 49:11–27PubMedCrossRef
84.
Zurück zum Zitat Marchetti B et al (1991) A potential role for catecholamines in the development and progression of carcinogen-induced mammary tumors: hormonal control of beta-adrenergic receptors and correlation with tumor growth. J Steroid Biochem Mol Biol 38:307–320PubMedCrossRef Marchetti B et al (1991) A potential role for catecholamines in the development and progression of carcinogen-induced mammary tumors: hormonal control of beta-adrenergic receptors and correlation with tumor growth. J Steroid Biochem Mol Biol 38:307–320PubMedCrossRef
85.
Zurück zum Zitat Masur K et al (2001) Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by beta-blockers. Cancer Res 61:2866–2869PubMed Masur K et al (2001) Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by beta-blockers. Cancer Res 61:2866–2869PubMed
86.
Zurück zum Zitat Maunsell E, Brisson J, Deschenes L (1995) Social support and survival among women with breast cancer. Cancer 76:631–637PubMedCrossRef Maunsell E, Brisson J, Deschenes L (1995) Social support and survival among women with breast cancer. Cancer 76:631–637PubMedCrossRef
87.
Zurück zum Zitat Maunsell E et al (2001) Stressful life events and survival after breast cancer. Psychosom Med 63:306–315PubMed Maunsell E et al (2001) Stressful life events and survival after breast cancer. Psychosom Med 63:306–315PubMed
88.
Zurück zum Zitat McCoy JL, Rucker R, Petros JA (2000) Cell-mediated immunity to tumor-associated antigens is a better predictor of survival in early stage breast cancer than stage, grade or lymph node status. Breast Cancer Res Treat 60:227–234PubMedCrossRef McCoy JL, Rucker R, Petros JA (2000) Cell-mediated immunity to tumor-associated antigens is a better predictor of survival in early stage breast cancer than stage, grade or lymph node status. Breast Cancer Res Treat 60:227–234PubMedCrossRef
89.
90.
Zurück zum Zitat Miller GE, Rohleder N, Cole SW (2009) Chronic interpersonal stress predicts activation of pro- and anti-inflammatory signaling pathways 6 months later. Psychosom Med 71:57–62PubMedCrossRef Miller GE, Rohleder N, Cole SW (2009) Chronic interpersonal stress predicts activation of pro- and anti-inflammatory signaling pathways 6 months later. Psychosom Med 71:57–62PubMedCrossRef
91.
Zurück zum Zitat Molassiotis A, van den Akker OB, Boughton BJ (1997) Perceived social support, family environment and psychosocial recovery in bone marrow transplant long-term survivors. Soc Sci Med 44:317–325PubMedCrossRef Molassiotis A, van den Akker OB, Boughton BJ (1997) Perceived social support, family environment and psychosocial recovery in bone marrow transplant long-term survivors. Soc Sci Med 44:317–325PubMedCrossRef
92.
93.
Zurück zum Zitat Moradi MM et al (1993) Serum and ascitic fluid levels of interleukin-1, interleukin-6, and tumor necrosis factor-alpha in patients with ovarian epithelial cancer. Cancer 72:2433–2440PubMedCrossRef Moradi MM et al (1993) Serum and ascitic fluid levels of interleukin-1, interleukin-6, and tumor necrosis factor-alpha in patients with ovarian epithelial cancer. Cancer 72:2433–2440PubMedCrossRef
94.
Zurück zum Zitat Moran TJ et al (2000) The glucocorticoid receptor mediates a survival signal in human mammary epithelial cells. Cancer Res 60:867–872PubMed Moran TJ et al (2000) The glucocorticoid receptor mediates a survival signal in human mammary epithelial cells. Cancer Res 60:867–872PubMed
95.
Zurück zum Zitat Nilsson MB et al (2007) Stress hormones regulate interleukin-6 expression by human ovarian carcinoma cells through a Src-dependent mechanism. J Biol Chem 282:29919–29926PubMedCrossRef Nilsson MB et al (2007) Stress hormones regulate interleukin-6 expression by human ovarian carcinoma cells through a Src-dependent mechanism. J Biol Chem 282:29919–29926PubMedCrossRef
96.
Zurück zum Zitat Palm D et al (2006) The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by beta-blockers. Int J Cancer 118:2744–2749PubMedCrossRef Palm D et al (2006) The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by beta-blockers. Int J Cancer 118:2744–2749PubMedCrossRef
97.
Zurück zum Zitat Pang D et al (2006) Dexamethasone decreases xenograft response to paclitaxel through inhibition of tumor cell apoptosis. Cancer Biol Ther 5:933–940PubMedCrossRef Pang D et al (2006) Dexamethasone decreases xenograft response to paclitaxel through inhibition of tumor cell apoptosis. Cancer Biol Ther 5:933–940PubMedCrossRef
98.
Zurück zum Zitat Penson RT et al (2000) Cytokines IL-1beta, IL-2, IL-6, IL-8, MCP-1, GM-CSF and TNFalpha in patients with epithelial ovarian cancer and their relationship to treatment with paclitaxel. Int J Gynecol Cancer 10:33–41PubMedCrossRef Penson RT et al (2000) Cytokines IL-1beta, IL-2, IL-6, IL-8, MCP-1, GM-CSF and TNFalpha in patients with epithelial ovarian cancer and their relationship to treatment with paclitaxel. Int J Gynecol Cancer 10:33–41PubMedCrossRef
99.
Zurück zum Zitat Pifl C et al (2001) Antiproliferative action of dopamine and norepinephrine in neuroblastoma cells expressing the human dopamine transporter. FASEB J 15:1607–1609PubMed Pifl C et al (2001) Antiproliferative action of dopamine and norepinephrine in neuroblastoma cells expressing the human dopamine transporter. FASEB J 15:1607–1609PubMed
100.
Zurück zum Zitat Plante M et al (1994) Interleukin-6 level in serum and ascites as a prognostic factor in patients with epithelial ovarian cancer. Cancer 73:1882–1888PubMedCrossRef Plante M et al (1994) Interleukin-6 level in serum and ascites as a prognostic factor in patients with epithelial ovarian cancer. Cancer 73:1882–1888PubMedCrossRef
101.
Zurück zum Zitat Prieto JM et al (2005) Role of depression as a predictor of mortality among cancer patients after stem-cell transplantation. J Clin Oncol 23:6063–6071PubMedCrossRef Prieto JM et al (2005) Role of depression as a predictor of mortality among cancer patients after stem-cell transplantation. J Clin Oncol 23:6063–6071PubMedCrossRef
102.
Zurück zum Zitat Rangarajan S et al (2003) Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor. J Cell Biol 160:487–493PubMedCrossRef Rangarajan S et al (2003) Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor. J Cell Biol 160:487–493PubMedCrossRef
103.
Zurück zum Zitat Rath KS et al (2010) Expression of soluble interleukin-6 receptor in malignant ovarian tissue. Am J Obstet Gynecol 203:230, e1–e8PubMedCrossRef Rath KS et al (2010) Expression of soluble interleukin-6 receptor in malignant ovarian tissue. Am J Obstet Gynecol 203:230, e1–e8PubMedCrossRef
104.
Zurück zum Zitat Reynolds P et al (1994) The relationship between social ties and survival among black and white breast cancer patients. National Cancer Institute Black/White Cancer Survival Study Group. Cancer Epidemiol Biomarkers Prev 3:253–259PubMed Reynolds P et al (1994) The relationship between social ties and survival among black and white breast cancer patients. National Cancer Institute Black/White Cancer Survival Study Group. Cancer Epidemiol Biomarkers Prev 3:253–259PubMed
105.
Zurück zum Zitat Reynolds P et al (2000) Use of coping strategies and breast cancer survival: results from the Black/White Cancer Survival Study. Am J Epidemiol 152:940–949PubMedCrossRef Reynolds P et al (2000) Use of coping strategies and breast cancer survival: results from the Black/White Cancer Survival Study. Am J Epidemiol 152:940–949PubMedCrossRef
106.
Zurück zum Zitat Richlin VA et al (2004) Stress-induced enhancement of NF-kappaB DNA-binding in the peripheral blood leukocyte pool: effects of lymphocyte redistribution. Brain Behav Immun 18:231–237PubMedCrossRef Richlin VA et al (2004) Stress-induced enhancement of NF-kappaB DNA-binding in the peripheral blood leukocyte pool: effects of lymphocyte redistribution. Brain Behav Immun 18:231–237PubMedCrossRef
107.
Zurück zum Zitat Ross L et al (2009) No effect on survival of home psychosocial intervention in a randomized study of Danish colorectal cancer patients. Psychooncology 18:875–885PubMedCrossRef Ross L et al (2009) No effect on survival of home psychosocial intervention in a randomized study of Danish colorectal cancer patients. Psychooncology 18:875–885PubMedCrossRef
108.
Zurück zum Zitat Sastry KS et al (2007) Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation. J Biol Chem 282:14094–14100PubMedCrossRef Sastry KS et al (2007) Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation. J Biol Chem 282:14094–14100PubMedCrossRef
109.
Zurück zum Zitat Satin JR, Linden W, Phillips MJ (2009) Depression as a predictor of disease progression and mortality in cancer patients: a meta-analysis. Cancer 115:5349–5361PubMedCrossRef Satin JR, Linden W, Phillips MJ (2009) Depression as a predictor of disease progression and mortality in cancer patients: a meta-analysis. Cancer 115:5349–5361PubMedCrossRef
110.
Zurück zum Zitat Scambia G et al (1995) Prognostic significance of interleukin 6 serum levels in patients with ovarian cancer. Br J Cancer 71:354–356PubMedCrossRef Scambia G et al (1995) Prognostic significance of interleukin 6 serum levels in patients with ovarian cancer. Br J Cancer 71:354–356PubMedCrossRef
111.
Zurück zum Zitat Scarparo AC, Visconti MA, Castrucci AM (2006) Signalling pathways evoked by alpha1-adrenoceptors in human melanoma cells. Cell Biochem Funct 24:119–129PubMedCrossRef Scarparo AC, Visconti MA, Castrucci AM (2006) Signalling pathways evoked by alpha1-adrenoceptors in human melanoma cells. Cell Biochem Funct 24:119–129PubMedCrossRef
112.
Zurück zum Zitat Schulz KH, Gold S (2006) Psychische Belastungen, Immunfunktionen und Krankheitsentwicklungen. Die psychoneuroimmunologische Perspektive. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 49:759–772PubMedCrossRef Schulz KH, Gold S (2006) Psychische Belastungen, Immunfunktionen und Krankheitsentwicklungen. Die psychoneuroimmunologische Perspektive. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 49:759–772PubMedCrossRef
113.
Zurück zum Zitat Sephton SE et al (2009) Depression, cortisol, and suppressed cell-mediated immunity in metastatic breast cancer. Brain Behav Immun 23:1148–1155PubMedCrossRef Sephton SE et al (2009) Depression, cortisol, and suppressed cell-mediated immunity in metastatic breast cancer. Brain Behav Immun 23:1148–1155PubMedCrossRef
114.
Zurück zum Zitat Sephton SE et al (2000) Diurnal cortisol rhythm as a predictor of breast cancer survival. J Natl Cancer Inst 92:994–1000PubMedCrossRef Sephton SE et al (2000) Diurnal cortisol rhythm as a predictor of breast cancer survival. J Natl Cancer Inst 92:994–1000PubMedCrossRef
115.
Zurück zum Zitat Shahzad MM et al (2010) Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer growth and metastasis. J Biol Chem 285:35462–35470PubMedCrossRef Shahzad MM et al (2010) Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer growth and metastasis. J Biol Chem 285:35462–35470PubMedCrossRef
116.
Zurück zum Zitat Shirakawa F, Mizel SB (1989) In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C. Mol Cell Biol 9:2424–2430PubMed Shirakawa F, Mizel SB (1989) In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C. Mol Cell Biol 9:2424–2430PubMed
117.
Zurück zum Zitat Simon WE et al (1984) In vitro growth promotion of human mammary carcinoma cells by steroid hormones, tamoxifen, and prolactin. J Natl Cancer Inst 73:313–321PubMed Simon WE et al (1984) In vitro growth promotion of human mammary carcinoma cells by steroid hormones, tamoxifen, and prolactin. J Natl Cancer Inst 73:313–321PubMed
118.
Zurück zum Zitat Sood AK et al (2010) Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. J Clin Invest 120:1515–1523PubMedCrossRef Sood AK et al (2010) Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. J Clin Invest 120:1515–1523PubMedCrossRef
119.
Zurück zum Zitat Sood AK et al (2006) Stress hormone-mediated invasion of ovarian cancer cells. Clin Cancer Res 12:369–375PubMedCrossRef Sood AK et al (2006) Stress hormone-mediated invasion of ovarian cancer cells. Clin Cancer Res 12:369–375PubMedCrossRef
120.
Zurück zum Zitat Spiegel D, Giese-Davis J (2003) Depression and cancer: mechanisms and disease progression. Biol Psychiatry 54:269–282PubMedCrossRef Spiegel D, Giese-Davis J (2003) Depression and cancer: mechanisms and disease progression. Biol Psychiatry 54:269–282PubMedCrossRef
121.
Zurück zum Zitat Su F et al (2005) Psychological stress induces chemoresistance in breast cancer by upregulating mdr1. Biochem Biophys Res Commun 329:888–897PubMedCrossRef Su F et al (2005) Psychological stress induces chemoresistance in breast cancer by upregulating mdr1. Biochem Biophys Res Commun 329:888–897PubMedCrossRef
122.
Zurück zum Zitat Temel JS et al (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 363:733–742PubMedCrossRef Temel JS et al (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 363:733–742PubMedCrossRef
123.
Zurück zum Zitat Thaker PH et al (2006) Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med 12:939–944PubMedCrossRef Thaker PH et al (2006) Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med 12:939–944PubMedCrossRef
124.
Zurück zum Zitat Thaker PH, Lutgendorf SK, Sood AK (2007) The neuroendocrine impact of chronic stress on cancer. Cell Cycle 6:430–433PubMedCrossRef Thaker PH, Lutgendorf SK, Sood AK (2007) The neuroendocrine impact of chronic stress on cancer. Cell Cycle 6:430–433PubMedCrossRef
125.
Zurück zum Zitat Thaker PH, Sood AK (2008) Neuroendocrine influences on cancer biology. Semin Cancer Biol 18:164–170PubMedCrossRef Thaker PH, Sood AK (2008) Neuroendocrine influences on cancer biology. Semin Cancer Biol 18:164–170PubMedCrossRef
126.
Zurück zum Zitat Thornton LM et al (2007) Individual trajectories in stress covary with immunity during recovery from cancer diagnosis and treatments. Brain Behav Immun 21:185–194PubMedCrossRef Thornton LM et al (2007) Individual trajectories in stress covary with immunity during recovery from cancer diagnosis and treatments. Brain Behav Immun 21:185–194PubMedCrossRef
127.
Zurück zum Zitat Trikas P et al (2002) Low psychopathology scores in the prognosis of breast cancer. A preliminary report. Psychother Psychosom 71:162–167PubMedCrossRef Trikas P et al (2002) Low psychopathology scores in the prognosis of breast cancer. A preliminary report. Psychother Psychosom 71:162–167PubMedCrossRef
128.
Zurück zum Zitat Tross S et al (1996) Psychological symptoms and disease-free and overall survival in women with stage II breast cancer. Cancer and Leukemia Group B. J Natl Cancer Inst 88:661–667PubMedCrossRef Tross S et al (1996) Psychological symptoms and disease-free and overall survival in women with stage II breast cancer. Cancer and Leukemia Group B. J Natl Cancer Inst 88:661–667PubMedCrossRef
129.
Zurück zum Zitat Tschuschke V et al (2001) Associations between coping and survival time of adult leukemia patients receiving allogeneic bone marrow transplantation: results of a prospective study. J Psychosom Res 50:277–285PubMedCrossRef Tschuschke V et al (2001) Associations between coping and survival time of adult leukemia patients receiving allogeneic bone marrow transplantation: results of a prospective study. J Psychosom Res 50:277–285PubMedCrossRef
130.
Zurück zum Zitat Tsigos C, Chrousos GP (2002) Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosom Res 53:865–871PubMedCrossRef Tsigos C, Chrousos GP (2002) Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosom Res 53:865–871PubMedCrossRef
131.
Zurück zum Zitat Vandewalle B, Revillion F, Lefebvre J (1990) Functional beta-adrenergic receptors in breast cancer cells. J Cancer Res Clin Oncol 116:303–306PubMedCrossRef Vandewalle B, Revillion F, Lefebvre J (1990) Functional beta-adrenergic receptors in breast cancer cells. J Cancer Res Clin Oncol 116:303–306PubMedCrossRef
132.
Zurück zum Zitat Vossler MR et al (1997) cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell 89:73–82PubMedCrossRef Vossler MR et al (1997) cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell 89:73–82PubMedCrossRef
133.
Zurück zum Zitat Watson M et al (2005) Influence of psychological response on breast cancer survival: 10-year follow-up of a population-based cohort. Eur J Cancer 41:1710–1714PubMedCrossRef Watson M et al (2005) Influence of psychological response on breast cancer survival: 10-year follow-up of a population-based cohort. Eur J Cancer 41:1710–1714PubMedCrossRef
134.
Zurück zum Zitat Waxler-Morrison N et al (1991) Effects of social relationships on survival for women with breast cancer: a prospective study. Soc Sci Med 33:177–183PubMedCrossRef Waxler-Morrison N et al (1991) Effects of social relationships on survival for women with breast cancer: a prospective study. Soc Sci Med 33:177–183PubMedCrossRef
135.
Zurück zum Zitat Webster JI, Tonelli L, Sternberg EM (2002) Neuroendocrine regulation of immunity. Annu Rev Immunol 20:125–163PubMedCrossRef Webster JI, Tonelli L, Sternberg EM (2002) Neuroendocrine regulation of immunity. Annu Rev Immunol 20:125–163PubMedCrossRef
136.
Zurück zum Zitat Wei LH et al (2003) Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway. Oncogene 22:1517–1527PubMedCrossRef Wei LH et al (2003) Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway. Oncogene 22:1517–1527PubMedCrossRef
137.
Zurück zum Zitat Weihs KL et al (2000) Negative affectivity, restriction of emotions, and site of metastases predict mortality in recurrent breast cancer. J Psychosom Res 49:59–68PubMedCrossRef Weihs KL et al (2000) Negative affectivity, restriction of emotions, and site of metastases predict mortality in recurrent breast cancer. J Psychosom Res 49:59–68PubMedCrossRef
138.
Zurück zum Zitat Whiteside TL, Herberman RB (1989) The role of natural killer cells in human disease. Clin Immunol Immunopathol 53:1–23PubMedCrossRef Whiteside TL, Herberman RB (1989) The role of natural killer cells in human disease. Clin Immunol Immunopathol 53:1–23PubMedCrossRef
139.
Zurück zum Zitat Wu J, Janknecht R (2002) Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A. J Biol Chem 277:42669–42679PubMedCrossRef Wu J, Janknecht R (2002) Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A. J Biol Chem 277:42669–42679PubMedCrossRef
140.
Zurück zum Zitat Wu W et al (2004) Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cells. Cancer Res 64:1757–1764PubMedCrossRef Wu W et al (2004) Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cells. Cancer Res 64:1757–1764PubMedCrossRef
141.
Zurück zum Zitat Yamasaki S et al (1993) Relationship between immunological parameters and survival of patients with liver metastases from breast cancer given immuno-chemotherapy. Breast Cancer Res Treat 26:55–65PubMedCrossRef Yamasaki S et al (1993) Relationship between immunological parameters and survival of patients with liver metastases from breast cancer given immuno-chemotherapy. Breast Cancer Res Treat 26:55–65PubMedCrossRef
142.
Zurück zum Zitat Yang EV et al (2006) Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells. Cancer Res 66:10357–10364PubMedCrossRef Yang EV et al (2006) Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells. Cancer Res 66:10357–10364PubMedCrossRef
143.
Zurück zum Zitat Zhao XY et al (2000) Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor. Nat Med 6:703–706PubMedCrossRef Zhao XY et al (2000) Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor. Nat Med 6:703–706PubMedCrossRef
144.
Zurück zum Zitat Zhong H, Voll RE, Ghosh S (1998) Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol Cell 1:661–671PubMedCrossRef Zhong H, Voll RE, Ghosh S (1998) Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol Cell 1:661–671PubMedCrossRef
145.
Zurück zum Zitat Zorrilla EP et al (2001) The relationship of depression and stressors to immunological assays: a meta-analytic review. Brain Behav Immun 15:199–226PubMedCrossRef Zorrilla EP et al (2001) The relationship of depression and stressors to immunological assays: a meta-analytic review. Brain Behav Immun 15:199–226PubMedCrossRef
Metadaten
Titel
Psychoneuroimmunologie und Krebs
Neue Ergebnisse zu psychosozialen Einflüssen auf Tumorerkrankungen
verfasst von
Dr. J. Hefner
H. Csef
Publikationsdatum
01.09.2011
Verlag
Springer-Verlag
Erschienen in
Die Onkologie / Ausgabe 9/2011
Print ISSN: 2731-7226
Elektronische ISSN: 2731-7234
DOI
https://doi.org/10.1007/s00761-011-2077-x

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