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Die Ophthalmologie

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24.06.2022 | Limbusstammzellinsuffizienz | Leitthema

Regenerative Medizin für das Hornhautepithel

Zelltherapie in Wissenschaft und Klinik

verfasst von: PD Dr. Johannes Menzel-Severing, Kristina Spaniol, Florian Groeber-Becker, Gerd Geerling

Erschienen in: Die Ophthalmologie | Ausgabe 9/2022

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Zusammenfassung

Bei einer Verbrennung oder Verätzung der Augenoberfläche kann der Verlust von Limbusepithelstammzellen zu einer kompromittierten Selbsterneuerung des Hornhautepithels führen. Hierdurch kommt es zu einem dauerhaften Sehverlust. In diesen Situationen kann die Transplantation von kultivierten Limbusepithelzellen auf einer Amnionmembran oder einem Fibringel als Träger (Holoclar®, Holostem Terapie Avanzate s.r.l., Modena, Italien) zu einer Regeneration der Hornhautoberfläche beitragen. Die erforderlichen Zellen werden dem gesunden Partnerauge entnommen – sofern vorhanden. Alternative Zellquellen sind adulte Stammzellen aus anderen Körperregionen (Haarfollikel, Mundschleimhaut, mesenchymale Stromazellen) oder induzierte pluripotente Stammzellen (ursprünglich z. B. Hautfibroblasten). Das Umprogrammieren solcher Zellen kann unter Zuhilfenahme von Transkriptionsfaktoren erfolgen. Zusätzlich wird an biosynthetischen oder synthetischen Matrices gearbeitet, die nicht nur als Trägermaterial für die Transplantation dienen, sondern auch die Funktionen der Zellen (Selbsterneuerung, hornhautepitheltypischer Phänotyp) unterstützen sollen.

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Titel: Regenerative Medizin für das Hornhautepithel
Zelltherapie in Wissenschaft und Klinik
verfasst von: PD Dr. Johannes Menzel-Severing
Kristina Spaniol
Florian Groeber-Becker
Gerd Geerling
Publikationsdatum: 24.06.2022
Verlag: Springer Medizin
Schlagwort: Limbusstammzellinsuffizienz
Erschienen in: Die Ophthalmologie / Ausgabe 9/2022
Print ISSN: 2731-720X
Elektronische ISSN: 2731-7218
DOI: https://doi.org/10.1007/s00347-022-01674-8

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Springer Medizin

Regenerative Medizin für das Hornhautepithel

Zelltherapie in Wissenschaft und Klinik

Zusammenfassung

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

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Springer Medizin

Zusammenfassung

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