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Erschienen in: Lasers in Medical Science 8/2021

04.03.2021 | Original Article

Risk prediction by Raman spectroscopy for disease-free survival in oral cancers

verfasst von: Atanu Bhattacharjee, Arti Hole, Akshat Malik, Aditi Sahu, S. P. Singh, Atul Deshmukh, Sudhir Nair, Pankaj Chaturvedi, C. Murali Krishna

Erschienen in: Lasers in Medical Science | Ausgabe 8/2021

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Abstract

In the present study, the potential of Raman spectroscopy (RS) in predicting disease-free survival (DFS) in oral cancer patients has been explored. Raman spectra were obtained from the tumor and contralateral regions of 94 oral squamous cell carcinoma patients. These patients were managed surgically and recommended for adjuvant therapy. The Cox proportional survival analysis was carried out to identify the spectral regions that can be correlated to DFS. The survival analysis was performed with 95% confidence intervals, hazard ratio, and p-values in the 1200-1800 cm−1 spectral region. Out of a total of 182 spectral points, 76 were found to be correlating with DFS, suggesting their utility to predict the patient outcome. The cut-off points of each correlating RS-point values were defined and tested towards predicting the DFS. The performance of predicting the power of spectral points was validated through Brier value, and it was found to be closer to the actual progression. The 76 spectral points identified from the tumors have the potential to accurately predict DFS in oral squamous cell carcinoma through a relatively simplistic prediction model in the absence of confounding factors.
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Metadaten
Titel
Risk prediction by Raman spectroscopy for disease-free survival in oral cancers
verfasst von
Atanu Bhattacharjee
Arti Hole
Akshat Malik
Aditi Sahu
S. P. Singh
Atul Deshmukh
Sudhir Nair
Pankaj Chaturvedi
C. Murali Krishna
Publikationsdatum
04.03.2021
Verlag
Springer London
Erschienen in
Lasers in Medical Science / Ausgabe 8/2021
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-021-03276-3