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13.06.2022 | Sarkome | CME Zertifizierte Fortbildung

Immuntherapie und zielgerichtete Therapie von Gliomen

verfasst von: J.-M. Werner, G. Ceccon, G. R. Fink, Univ.-Prof. Dr. med. N. Galldiks

Erschienen in: DGNeurologie | Ausgabe 4/2022

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Zusammenfassung

Der Erfolg von Immuntherapien bei extrakranialen Tumoren führte zur Entwicklung verschiedener immunvermittelter Ansätze zur Behandlung von Gliomen. So gelang vor kurzem beispielsweise die Herstellung eines mutationsspezifischen Impfstoffs gegen IDH-mutierte (IDH: Isozitratdehydrogenase) Gliome. Weitere immuntherapeutische Ansätze sind T‑Zell-Therapien, die Blockade bestimmter Immuncheckpoints und die Behandlung mit onkolytischen Viren. Zudem scheinen zielgerichtete Therapien bei Gliompatienten mit seltenen molekulargenetischen Veränderungen wie z. B. einer BRAF-Mutation (BRAF: Serin-Threonin-Kinase B‑Raf, „v-Raf murine sarcoma viral oncogene homolog B“) oder NTRK-Gen-Fusion (NTRK: „neurotrophic tyrosine kinase receptor“) wirksam zu sein. Dieser Artikel bietet eine Übersicht über den aktuellen Stand der Therapieoptionen von Gliomen mittels Immuntherapien sowie zielgerichteter Behandlungen.

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Titel: Immuntherapie und zielgerichtete Therapie von Gliomen
verfasst von: J.-M. Werner
G. Ceccon
G. R. Fink
Univ.-Prof. Dr. med. N. Galldiks
Publikationsdatum: 13.06.2022
Verlag: Springer Medizin
Schlagwörter: Sarkome
Glioblastom
Zielgerichtete Therapie
Gliome
Glioblastom
CAR-T-Zellen
Gliome
Gliome
Glioblastom
Erschienen in: DGNeurologie / Ausgabe 4/2022
Print ISSN: 2524-3446
Elektronische ISSN: 2524-3454
DOI: https://doi.org/10.1007/s42451-022-00450-x

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