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Erschienen in: Die Onkologie 8/2022

24.06.2022 | Endokrine Tumoren | Leitthema

Systemtherapie des anaplastischen Schilddrüsenkarzinoms

verfasst von: Prof. Dr. Christine Dierks

Erschienen in: Die Onkologie | Ausgabe 8/2022

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Zusammenfassung

Hintergrund

Anaplastische Schilddrüsenkarzinome (ATC) sind eine seltene, aber hoch aggressive Subgruppe der Schilddrüsenkarzinome mit einer Überlebenszeit von nur wenigen Monaten trotz multimodaler Therapie. Im frühen Stadium sind die Chirurgie und die Radiochemotherapie entscheidend für das Überleben der Patient*innen. Da jedoch über 90 % der ATC metastasieren, ist anschließend eine effektive Systemtherapie von essentieller Bedeutung.

Ziel

Ziel war die Darstellung aller klassischen und neuen systemischen Therapieoptionen beim ATC sowie der dazu notwendigen zielgerichteten molekularen Diagnostik.

Methoden

Es handelt sich um eine selektive Literaturrecherche sowie Auswertung des eigenen Patientenkollektivs.

Ergebnisse

Der Review fasst alle aktuellen systemischen Therapiekonzepte von klassischen Chemotherapien über molekularpathologische zielgerichtete Therapien mit Kinaseinhibitoren sowie immuntherapeutische Ansätze zusammen.

Schlussfolgerung

Durch diese neuen Therapiekonzepte kann die Prognose der Patient*innen mit ATC entscheidend verbessert werden.
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Metadaten
Titel
Systemtherapie des anaplastischen Schilddrüsenkarzinoms
verfasst von
Prof. Dr. Christine Dierks
Publikationsdatum
24.06.2022
Verlag
Springer Medizin
Erschienen in
Die Onkologie / Ausgabe 8/2022
Print ISSN: 2731-7226
Elektronische ISSN: 2731-7234
DOI
https://doi.org/10.1007/s00761-022-01198-5

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