Background
Methods
Searching strategy and source of information
Reporting
Eligibility criteria
Study type
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All observational study
Study content
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A study that reported about seroprevalence or Prevalence of hepatitis C viral infection using a valid HCV screening test.
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Prevalence is also calculated using the data presented in the studies.
Study period
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There was no restriction on the study period
Blood donor type
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There was no restriction on the type of blood donors
Exclusion criteria
Study selection and extraction
Quality assessment
Statistical analysis
Result
Search outcomes
Characteristics of included studies
Authors name | Sampling year | Publication year | Study area | Study region | Study design | Sample size | Prevalence % (95%ci) | Logit transformation | Study quality |
---|---|---|---|---|---|---|---|---|---|
2014 | 2016 | Jijiga | Somali | Cross-sectional | 6827 | 0.73 | −4.927207 | Low risk | |
Alemeshet Y. et al [40] | 2010 | 2011 | Jimma | Oromia | Cross-sectional | 6063 | 0.2 | −6.21661 | Low risk |
Shiferaw et al [26] | 2018 | 2019 | Bahirdar | Amhara | Cross-sectional | 35,435 | 0.6 | −5.122014 | Low risk |
Bekele Sharew et al [27] | 2012 | 2015 | Dessie | Amhara | Cross-sectional | 8908 | 0.61 | −5.105585 | Low risk |
Misganew B. [35] | 2013 | 2016 | Hawassa | SNNP | Cross-sectional | 6337 | 0.6 | −5.122014 | Low risk |
Dessie et al [28] | 2006 | 2007 | Bahirdar | Amhara | Cross-sectional | 324 | 13.3 | −2.160122 | Low risk |
Tigabu et al. [29] | 2018 | 2019 | Gondar | Amhara | Cross-sectional | 5983 | 1.6 | −4.151296 | Low risk |
Negash et al. [30] | 2018 | 2019 | Debrtabor | Amhara | Cross-sectional | 310 | 4.2 | −3.212993 | Low risk |
Bonja et al. [38] | 2015 | 2017 | Hawassa | SNNP | Cross-sectional | 384 | 0.5 | −5.30333 | Low risk |
Deressa et al. [31] | 2017 | 2018 | North Shewa | Amhara | Cross-sectional | 8460 | 0.32 | −5.747809 | Low risk |
Ambachew et al [36] | 2016 | 2018 | Hawassa | SNNP | Cross-sectional | 2237 | 0.5 | −5.30333 | Low risk |
Teklemariam et al. [46] | 2017 | 2018 | Harrer | Harari | Cross-sectional | 11,382 | 0.8 | −4.836346 | Low risk |
Zerihun A. et al [45] | 2013 | 2018 | Dire Dawa | Dire Dawa | Cross-sectional | 6376 | 0.96 | −4.655639 | Low risk |
Mohammed and Bekele [43] | 2013 | 2016 | Jijiga | Somali | Cross-sectional | 4224 | 0.4 | −5.525469 | Low risk |
Tessema et al [33] | 2007 | 2010 | Gondar | Amhara | Cross-sectional | 6361 | 0.7 | −4.96887 | Low risk |
Fithamlak S. [39] | 2015 | 2016 | W/Sodo | SNNP | Cross-sectional | 390 | 8.5 | −2.553935 | Low risk |
DEGEFA ET AL. [44] | 2014 | 2018 | Mekelle | Tigray | Cross-sectional | 10,728 | 1.33 | −4.333381 | Low risk |
Biadgo et al [32] | 2012 | 2017 | North Gondar | Amhara | Retrospective Cohort | 6471 | 0.8 | −4.836346 | Low risk |
Jose M. et al [41] | 2012 | 2016 | Gambo Hospital | Oromia | Cross-sectional | 2606 | 2 | −3.932226 | Low risk |
HUNDIE ET AL [49] | 2014 | 2017 | Nationwide | Unspecifica | Cross-sectional | 56,885 | 0.52 | −5.26431 | Low risk |
Abate et al. [25] | 2008 | 2013 | Bahir Dar | Amhara | Cross-sectional | 2384 | 0.63 | −5.073525 | Low risk |
Heyredin et al [48] | 2018 | 2019 | Eastern Ethiopia | Unspecifica | Cross-sectional | 500 | 1 | −4.615221 | Low risk |
Mengistu Hailemariam [37] | 2015 | 2018 | Hawassa | SNNP | Cross-sectional | 6849 | 0.7 | −4.96887 | Low risk |
Gelaw and Mengistu [47] | 2003 | 2008 | Amhara & Tigray | Unspecifica | Cross-sectional | 600 | 1.7 | −4.091688 | Low risk |
Tigistu Demisse [34] | 2014 | Unpublished | W/Sodo | SNNP | Cross-sectional | 148 | 8.8 | −2.522534 | Low risk |
Publication bias
Trim and fill analysis (metatrim)
Seroprevalence of hepatitis c virus infection
A leave-out-one sensitivity analysis
Study omitted | Pooled estimate | 95%CI |
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Melese A. et al/ [42] | 0.827 | 0.671–0.983 |
Alemeshet Y. et al [40] | 0.851 | 0.701–1.002 |
Shiferaw et al [26] | 0.853 | 0.684–1.023 |
Bekele Sharew et al [27] | 0.837 | 0.679–0.995 |
Misganew [35] | 0.836 | 0.679 0.992 |
Dessie et al [28] | 0.788 | 0.649–0.928 |
Tigabu et al. [29] | 0.771 | 0.626–0.915 |
Negash et al. [30] | 0.803 | 0.655–0.950 |
Bonja et al. [38] | 0.828 | 0.676–0.980 |
Deressa et al. [31] | 0.852 | 0.696–1.009 |
Ambachew et al [36] | 0.837 | 0.682–0.991 |
Teklemariam et al. [46] | 0.823 | 0.667–0.979 |
Zerihun A. et al [45] | 0.811 | 0.658–0.964 |
Mohammed and Bekele [43] | 0.846 | 0.690–1.002 |
Tessema et al [33] | 0.829 | 0.673–0.985 |
Fithamlak S. [39] | 0.790 | 0.648–0.933 |
DEGEFA ET AL. [44] | 0.779 | 0.634–0.923 |
Biadgo et al [32] | 0.822 | 0.667–0.977 |
Jose M. etal [41] | 0.772 | 0.626–0.918 |
HUNDIE ET AL [49] | 0.868 | 0.691–1.045 |
Abate et al. [25] | 0.830 | 0.676–0.984 |
Heyredin et al [48] | 0.816 | 0.665–0.967 |
Mengistu Hailemariam [37] | 0.829 | 0.673–0.985 |
Gelaw and Mengistu [47] | 0.805 | 0.655–0.954 |
Tigistu Demisse [34] | 0.808 | 0.661–0.955 |
Subgroup analysis
Variable | Characteristics | Pooled seroprevalence 95%(CI) | I2(p-value) |
---|---|---|---|
Region | Somali | 0.563%(0.240, 0.887) | 81.6%(0.02) |
Oromia | 1.080%(−0.684–2.844) | 97.6%(< 0.001) | |
Amhara | 0.847%(0.576, 1.117) | 93.2%(< 0.001) | |
SNNP | 0.908%(0.408, 1.408) | 88.8%(< 0.001) | |
By year of publication | < 2010 | 7.359%(−4.006, 18.723) | 97.1%(< 0.001) |
2010–2014 | 0.497%(0.124, 0.87) | 90.5%(< 0.001) | |
2015–2019 | 0.814%(0.667, 0.96) | 91.1%(< 0.001) |
Discussion
Strength and limitation of the study
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This study used a comprehensive searching strategy and looked at both published and unpublished studies through the different datasets to estimate the national seroprevalence of hepatitis C virus.
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More than one assessor was used in the quality evaluation and appraisal process using JBI-MAStARI.
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It might lack national representativeness since no information was found from Afar, Gambella, and Benishangul-Gumuz regions.