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Indian Journal of Surgical Oncology

Erschienen in:

03.03.2021 | Original Article

Small Bowel PCI Score as a Prognostic Factor of Ovarian Cancer Patients Undergoing Cytoreductive Surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC), a Retrospective Analysis of 130 Patients

verfasst von: Christos Iavazzo, Alexandros Fotiou, Victoria Psomiadou, Sofia Lekka, Dimitrios Katsanos, John Spiliotis

Erschienen in: Indian Journal of Surgical Oncology | Ausgabe 2/2021

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Abstract

Ovarian cancer is the leading cause of death among gynecologic malignancies. Combining cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) can benefit patients with advanced ovarian cancer. We evaluate the role of small bowel peritoneal cancer index (sb-PCI) score as a prognostic factor. We retrospectively analyzed characteristics and clinical outcomes of patients that underwent intermediate cytoreductive surgery combined with HIPEC after neoadjuvant chemotherapy and patient’s characteristics underwent debulking surgery plus HIPEC for recurrence disease. One hundred thirty patients were included. Eighty-five of them (65.4%) were treated for recurrent ovarian cancer, while 45 (34.6%) underwent intermediate cytoreductive surgery after neoadjuvant chemotherapy with a mean age of 52 years. Mean intraoperative peritoneal cancer index (PCI) was 11.84 with a mean sb-PCI score of 5.57. Univariate analysis revealed that PCI, sb-PCI, and completeness of cytoreduction (CC) were parameters that correlated significantly with overall survival, while after multivariate analysis sb-PCI and CC were identified as independent prognostic factors of survival. A statistically significant correlation between sb-PCI score and overall survival of patients with advanced ovarian cancer was revealed. Further larger future studies are required to confirm our conclusion in order to change the treatment of advanced ovarian cancer patients.

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Titel: Small Bowel PCI Score as a Prognostic Factor of Ovarian Cancer Patients Undergoing Cytoreductive Surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC), a Retrospective Analysis of 130 Patients
verfasst von: Christos Iavazzo
Alexandros Fotiou
Victoria Psomiadou
Sofia Lekka
Dimitrios Katsanos
John Spiliotis
Publikationsdatum: 03.03.2021
Verlag: Springer India
Erschienen in: Indian Journal of Surgical Oncology / Ausgabe 2/2021
Print ISSN: 0975-7651
Elektronische ISSN: 0976-6952
DOI: https://doi.org/10.1007/s13193-021-01304-w

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