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Erschienen in: Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 9/2015

01.09.2015 | Bekanntmachungen - Amtliche Mitteilungen

Stoffmonographie für 2-Mercaptobenzothiazol (2-MBT) und HBM-Werte für 2-MBT im Urin von Erwachsenen und Kindern

Stellungnahme der Kommission „Human-Biomonitoring“ des Umweltbundesamtes

verfasst von: Bekanntmachung des Umweltbundesamtes

Erschienen in: Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz | Ausgabe 9/2015

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Zusammenfassung

2-Mercaptobenzothiazol (2-MBT, CAS-Nr. 149-30-4) wird hauptsächlich als Vulkanisationsbeschleuniger in der Gummiherstellung eingesetzt. Darüber hinaus wird diese Substanz auch als Fungizid in Farben, Fasern oder zur äußeren Anwendung bei Tieren verwendet. Aufgrund des vielfältigen Einsatzes von 2-MBT in Verbraucherprodukten, darunter auch Babyschnuller, kommt es zur Exposition der Allgemeinbevölkerung. Zur toxikologischen Einschätzung einer möglichen körperlichen Belastung hat die HBM-Kommission HBM-Werte für 2-MBT im Urin von Kindern und Erwachsenen abgeleitet. Als Ausgangspunkt (point of departure, POD) für die HBM-Wert-Ableitung wurde der No Observed Adverse Effect Level (NOAEL) von 94 mg/kg KG/Tag aus einer subchronischen Studie an Mäusen nach oraler Gabe von 2-MBT herangezogen. Unter Berücksichtigung eines Gesamt-Assessmentfaktors von 350 ergibt sich für den Menschen ein Wert von 0,3 mg/kg Kg/Tag für die täglich tolerierbare Aufnahme. Unter der aus Tierversuchen hergeleiteten Annahme, dass neben 2-MBT ein erheblicher Anteil des aufgenommenen 2-MBT als Glucuronid im Urin ausgeschieden wird, sowie der Berücksichtigung der körpergewichtsproportionalen Urinmenge ergibt sich ein HBM-I-Wert für 2-MBT im Urin von Kindern von 4,5 mg/L und ein HBM-I-Wert für 2-MBT im Urin von Erwachsenen von 7 mg/L.
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Fußnoten
1
Synonyme: Benzothiazol-2-thiol, 2-(3H)-Benzothiazolthion.
 
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Metadaten
Titel
Stoffmonographie für 2-Mercaptobenzothiazol (2-MBT) und HBM-Werte für 2-MBT im Urin von Erwachsenen und Kindern
Stellungnahme der Kommission „Human-Biomonitoring“ des Umweltbundesamtes
verfasst von
Bekanntmachung des Umweltbundesamtes
Publikationsdatum
01.09.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz / Ausgabe 9/2015
Print ISSN: 1436-9990
Elektronische ISSN: 1437-1588
DOI
https://doi.org/10.1007/s00103-015-2212-8

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