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Erschienen in:

01.08.2008

Tailoring Treatment with Tirofiban in Patients Showing Resistance to Aspirin and/or Resistance to Clopidogrel (3T/2R). Rationale for the Study and Protocol Design

verfasst von: Marco Valgimigli, Gianluca Campo, Nicoletta de Cesare, Pascal Vranckx, Martial Hamon, Dominick J. Angiolillo, Manel Sabatè, Fabrizio Ferrari, Alessandro Furgieri, Carlo Tumscitz, Alessandra Repetto, Salvatore Colangelo, Emanuele Meliga, Moh’d Kubbajeh, Giovanni Parrinello, Gianfranco Percoco, Roberto Ferrari

Erschienen in: Cardiovascular Drugs and Therapy | Ausgabe 4/2008

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Abstract

Purpose

To assess whether glycoprotein IIb/IIIa inhibition using tirofiban in low risk patients undergoing percutaneous coronary intervention (PCI) may reduce the risk of periprocedural myocardial infarction compared to standard care in poor responders to aspirin and/or clopidogrel.

Methods

We will enroll patients at ten European sites or more to participate in the Tailoring Treatment with Tirofiban in patients showing Resistance to aspirin and/or Resistance to clopidogrel (3T/2R) study with a pre-specified sample size of 240 patients out of 1,100 or more who will undergo screening. The primary outcome measure is troponin I or T elevation ratio at least three times the upper limit of normal within 48 h after completion of the PCI.

Conclusion

The results of 3T/2R study will evaluate whether tailored intensification of anti-platelet treatment based on poor individual response to oral anti-platelet agents may modulate the risk of periprocedural myocardial infarction during PCI. Our findings attempt at unraveling a new era of individualized anti-platelet treatment through the use of point-of-care assessment.
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Metadaten
Titel
Tailoring Treatment with Tirofiban in Patients Showing Resistance to Aspirin and/or Resistance to Clopidogrel (3T/2R). Rationale for the Study and Protocol Design
verfasst von
Marco Valgimigli
Gianluca Campo
Nicoletta de Cesare
Pascal Vranckx
Martial Hamon
Dominick J. Angiolillo
Manel Sabatè
Fabrizio Ferrari
Alessandro Furgieri
Carlo Tumscitz
Alessandra Repetto
Salvatore Colangelo
Emanuele Meliga
Moh’d Kubbajeh
Giovanni Parrinello
Gianfranco Percoco
Roberto Ferrari
Publikationsdatum
01.08.2008
Verlag
Springer US
Erschienen in
Cardiovascular Drugs and Therapy / Ausgabe 4/2008
Print ISSN: 0920-3206
Elektronische ISSN: 1573-7241
DOI
https://doi.org/10.1007/s10557-008-6121-z

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