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Erschienen in: Calcified Tissue International 3/2024

04.02.2024 | Original Research

The Effect of Rheumatoid Arthritis on Features Associated with Sarcopenia: A Mendelian Randomization Study

verfasst von: Kaixi Ding, Wei Jiang, Juejue Zhangwang, Jian Li, Ming Lei

Erschienen in: Calcified Tissue International | Ausgabe 3/2024

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Abstract

Previous epidemiological evidence suggests rheumatoid arthritis is associated with sarcopenia-related features. However, most of the current evidence is from cross-sectional studies, and the causal link of this association is still to be determined. Therefore, this study was committed to a two-sample Mendelian randomization analysis to assess the causal effect of rheumatoid arthritis on sarcopenia-related features. In this two-sample Mendelian randomization study, instrumental variables for rheumatoid arthritis were obtained from the Non-Cancer Disease Study, and data for the five relevant characteristics of sarcopenia were pooled from UKBiobank. Inverse variance weighting is the primary analysis method for assessing causal effects. MR-Egger regression and weighted median are complementary analysis methods for causal effects. Leave-one-out analysis, horizontal pleiotropy test, and Heterogeneity test are applied as a sensitivity analysis to assess the robustness of causal effect estimates. The inverse variance weighted results for the five characteristics associated with sarcopenia and rheumatoid arthritis were: hand grip strength (right) (beta = − 2.309, se = 0.206, p = 3.340E-29), hand grip strength (left) (beta = − 2.046, se = 0.205, p = 2.166E-23), whole body lean mass (beta = − 0.843, se = 0.135, p = 4.67E-10), appendicular lean mass (beta = − 2.444, se = 0.208, p = 6.069E-32), Usual walking pace (OR 0.340, 95% CI (0.238, 0.484), p = 2.471E-09). The sensitivity analyses did not support that horizontal pleiotropy distorted causal effect estimates. The beta coefficient quantifies the number of standard deviations of the continuous outcome variables (hand grip strength, whole body lean mass, and appendicular lean mass) that change on average with each increase in the standard deviation of the binary exposure variable (rheumatoid arthritis). The odds ratios indicate the increased risk of the binary outcome variable (usual walking pace) per rheumatoid arthritis standard deviation increase. This study has demonstrated a negative causal effect of rheumatoid arthritis with five major sarcopenia-related features in a European population.
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Literatur
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Zurück zum Zitat Gómez-SanMiguel AB, Martín AI, Nieto-Bona MP, Fernández-Galaz C, Villanúa MÁ, López-Calderón A (2016) The melanocortin receptor type 3 agonistd-Trp(8)-γMSH decreases inflammation and muscle wasting in arthritic rats: <Scp>d</scp>-Trp(8)- MSH decreases inflammatory cachexia. J Cachexia Sarcopenia Muscle 7(1):79–89. https://doi.org/10.1002/jcsm.12036CrossRefPubMed Gómez-SanMiguel AB, Martín AI, Nieto-Bona MP, Fernández-Galaz C, Villanúa MÁ, López-Calderón A (2016) The melanocortin receptor type 3 agonistd-Trp(8)-γMSH decreases inflammation and muscle wasting in arthritic rats: <Scp>d</scp>-Trp(8)- MSH decreases inflammatory cachexia. J Cachexia Sarcopenia Muscle 7(1):79–89. https://​doi.​org/​10.​1002/​jcsm.​12036CrossRefPubMed
Metadaten
Titel
The Effect of Rheumatoid Arthritis on Features Associated with Sarcopenia: A Mendelian Randomization Study
verfasst von
Kaixi Ding
Wei Jiang
Juejue Zhangwang
Jian Li
Ming Lei
Publikationsdatum
04.02.2024
Verlag
Springer US
Erschienen in
Calcified Tissue International / Ausgabe 3/2024
Print ISSN: 0171-967X
Elektronische ISSN: 1432-0827
DOI
https://doi.org/10.1007/s00223-023-01178-w

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