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Erschienen in: Inflammation Research 10-11/2022

05.09.2022 | Review

The role of adenosine A1 receptor on immune cells

verfasst von: Lingyu Zhong, Qiao Peng, Xun Zeng

Erschienen in: Inflammation Research | Ausgabe 10-11/2022

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Abstract

Background

Adenosine, acting as a regulator by mediating the activation of G protein-coupled adenosine receptor families (A1, A2A, A2B, and A3), plays an important role under physiological and pathological conditions. As the receptor with the highest affinity for adenosine, the role of adenosine A1 receptor (A1R)-mediated adenosine signaling pathway in the central nervous system has been well addressed. However, functions of A1R on immune cells are less summarized. Considering that some immune cells express multiple types of adenosine receptors with distinct effects and varied density, exogenous adenosine of different concentrations may induce divergent immune cell functions.

Materials and methods

The literatures about the expression of A1R and its regulation on immune cells and how it regulates the function of immune cells were searched on PubMed and Google Scholar.

Conclusion

In this review, we discussed the effects of A1R on immune cells, including monocytes, macrophages, neutrophils, dendritic cells, and microglia, and focused on the role of A1R in regulating immune cells in diseases, which may facilitate our understanding of the mechanisms by which adenosine affects immune cells through A1R.
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Metadaten
Titel
The role of adenosine A1 receptor on immune cells
verfasst von
Lingyu Zhong
Qiao Peng
Xun Zeng
Publikationsdatum
05.09.2022
Verlag
Springer International Publishing
Erschienen in
Inflammation Research / Ausgabe 10-11/2022
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-022-01607-w

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