Skip to main content
Erschienen in:

01.08.2005 | Leitthema

Therapieprinzipien beim Lokalrezidiv des Rektumkarzinoms

verfasst von: PD Dr. B. Rau, S. Koswig, B. Gebauer, B. Hildebrandt, J. Gellermann

Erschienen in: Die Onkologie | Ausgabe 8/2005

Einloggen, um Zugang zu erhalten

Zusammenfassung

Beim isolierten Lokalrezidiv im kleinen Becken besteht zu ca. 30% die Möglichkeit der R0-Resektion. Da erwartungsgemäß bei Rezidiveingriffen im kleinen Becken die Komplikationsrate erhöht ist, sollte als erstes eine präzise Diagnostik erfolgen, die die Lokalisation des Rezidivtumors und das Ausmaß der Resektion widerspiegelt. Bei Ausschluss von Fernmetastasen sollte — wenn möglich — eine präoperative Radiochemotherapie vor Rezidivoperation erfolgen. Ist ein kuratives Konzept nicht durchführbar, verbleibt die Strahlentherapie als palliative Maßnahme. Diese Arbeit stellt verschiedene Behandlungsmöglichkeiten und Therapiealgorithmen des lokal isoliert rezidivierten Rektumkarzinoms vor, die aus großen klinischen Studien sowie Erfahrungen am eigenen Krankengut bezogen wurden.
Literatur
1.
Zurück zum Zitat Tepper JE, O’Connell M, Hollis D et al. (2003) Analysis of surgical salvage after failure of primary therapy in rectal cancer: results from Intergroup Study 0114. J Clin Oncol 21:3623–3628CrossRefPubMed Tepper JE, O’Connell M, Hollis D et al. (2003) Analysis of surgical salvage after failure of primary therapy in rectal cancer: results from Intergroup Study 0114. J Clin Oncol 21:3623–3628CrossRefPubMed
2.
Zurück zum Zitat Miner TJ, Jaques DP, Paty PB, Guillem JG, Wong WD (2003) Symptom control in patients with locally recurrent rectal cancer. Ann Surg Oncol 10:72–79 Miner TJ, Jaques DP, Paty PB, Guillem JG, Wong WD (2003) Symptom control in patients with locally recurrent rectal cancer. Ann Surg Oncol 10:72–79
3.
Zurück zum Zitat Schmiegel W, Pox C, Adler G (2004) S3 Leitlinienkonferenz „Kolorektales Karzinom“ 2004. Z Gastroenterol 42:1129–1177CrossRefPubMed Schmiegel W, Pox C, Adler G (2004) S3 Leitlinienkonferenz „Kolorektales Karzinom“ 2004. Z Gastroenterol 42:1129–1177CrossRefPubMed
4.
Zurück zum Zitat Hünerbein M, Dohmoto M, Haensch W, Schlag PM (1996) Evaluation and biopsy of recurrent rectal cancer using three-dimensional endosonography. Dis Colon Rectum 39:1373–1378PubMed Hünerbein M, Dohmoto M, Haensch W, Schlag PM (1996) Evaluation and biopsy of recurrent rectal cancer using three-dimensional endosonography. Dis Colon Rectum 39:1373–1378PubMed
5.
Zurück zum Zitat Hünerbein M, Totkas S, Moesta KT et al. (2001) The role of transrectal ultrasound-guided biopsy in the postoperative follow-up of patients with rectal cancer. Surgery 129:164–169CrossRefPubMed Hünerbein M, Totkas S, Moesta KT et al. (2001) The role of transrectal ultrasound-guided biopsy in the postoperative follow-up of patients with rectal cancer. Surgery 129:164–169CrossRefPubMed
6.
Zurück zum Zitat Torricelli P, Pecchi A, Luppi G, Romagnoli R (2003) Gadolinium-enhanced MRI with dynamic evaluation in diagnosing the local recurrence of rectal cancer. Abdom Imaging 28:19–27 Torricelli P, Pecchi A, Luppi G, Romagnoli R (2003) Gadolinium-enhanced MRI with dynamic evaluation in diagnosing the local recurrence of rectal cancer. Abdom Imaging 28:19–27
7.
Zurück zum Zitat Blomqvist L, Ohlsen H, Hindmarsh T, Jonsson E, Holm T (2000) Local recurrence of rectal cancer: MR imaging before and after oral superparamagnetic particles vs contrast-enhanced computed tomography. Eur Radiol 10:1383–1389CrossRefPubMed Blomqvist L, Ohlsen H, Hindmarsh T, Jonsson E, Holm T (2000) Local recurrence of rectal cancer: MR imaging before and after oral superparamagnetic particles vs contrast-enhanced computed tomography. Eur Radiol 10:1383–1389CrossRefPubMed
8.
Zurück zum Zitat Stuckle CA (2004) Recurrent rectal cancer: diagnosis by contrast enhancement in MD-CT. Radiologe DOI 10.1007/s00117-004-1141-6 Stuckle CA (2004) Recurrent rectal cancer: diagnosis by contrast enhancement in MD-CT. Radiologe DOI 10.1007/s00117-004-1141-6
9.
Zurück zum Zitat Franke J, Rosenzweig S, Reinartz P et al. (2000) Value of positron emission tomography (18F-FDG-PET) in the diagnosis of recurrent rectal cancer. Chirurg 71:80–85PubMed Franke J, Rosenzweig S, Reinartz P et al. (2000) Value of positron emission tomography (18F-FDG-PET) in the diagnosis of recurrent rectal cancer. Chirurg 71:80–85PubMed
10.
Zurück zum Zitat Wanebo HJ, Antoniuk P, Koness RJ et al. (1999) Pelvic resection of recurrent rectal cancer: technical considerations and outcomes. Dis Colon Rectum 42:1438–1448PubMed Wanebo HJ, Antoniuk P, Koness RJ et al. (1999) Pelvic resection of recurrent rectal cancer: technical considerations and outcomes. Dis Colon Rectum 42:1438–1448PubMed
11.
Zurück zum Zitat Suzuki K, Gunderson LL, Devine RM et al. Intraoperative irradiation after palliative surgery for locally recurrent rectal cancer. Cancer 1995; 75:939–952 Suzuki K, Gunderson LL, Devine RM et al. Intraoperative irradiation after palliative surgery for locally recurrent rectal cancer. Cancer 1995; 75:939–952
12.
Zurück zum Zitat Valentini V, Morganti AG, De Franco A et al. (1999) Chemoradiation with or without intraoperative radiation therapy in patients with locally recurrent rectal carcinoma: prognostic factors and long term outcome. Chirurg 86:2612–2624 Valentini V, Morganti AG, De Franco A et al. (1999) Chemoradiation with or without intraoperative radiation therapy in patients with locally recurrent rectal carcinoma: prognostic factors and long term outcome. Chirurg 86:2612–2624
13.
Zurück zum Zitat Hahnloser D, Nelson H, Gunderson LL et al. (2003) Curative potential of multimodality therapy for locally recurrent rectal cancer. Ann Surg 237:502–508PubMed Hahnloser D, Nelson H, Gunderson LL et al. (2003) Curative potential of multimodality therapy for locally recurrent rectal cancer. Ann Surg 237:502–508PubMed
14.
Zurück zum Zitat Jimenez RE, Shoup M, Cohen AM et al. (2003) Contemporary outcomes of total pelvic exenteration in the treatment of colorectal cancer. Dis Colon Rectum 46:1619–1625PubMed Jimenez RE, Shoup M, Cohen AM et al. (2003) Contemporary outcomes of total pelvic exenteration in the treatment of colorectal cancer. Dis Colon Rectum 46:1619–1625PubMed
15.
Zurück zum Zitat Ike H, Shimada H, Ohki S et al. (2003) Outcome of total pelvic exenteration for locally recurrent rectal cancer. Hepatogastroenterology 50:700–703PubMed Ike H, Shimada H, Ohki S et al. (2003) Outcome of total pelvic exenteration for locally recurrent rectal cancer. Hepatogastroenterology 50:700–703PubMed
16.
Zurück zum Zitat Campos FG, Habr-Gama A, Kiss DR et al. (2005) Management of the pelvic recurrence of rectal cancer with radiofrequency thermoablation: a case report and review of the literature. Int J Colorectal Dis 20:62–66CrossRefPubMed Campos FG, Habr-Gama A, Kiss DR et al. (2005) Management of the pelvic recurrence of rectal cancer with radiofrequency thermoablation: a case report and review of the literature. Int J Colorectal Dis 20:62–66CrossRefPubMed
17.
Zurück zum Zitat Hocht S, Hammad R, Thiel HJ et al. (2004) Recurrent rectal cancer within the pelvis. A multicenter analysis of 123 patients and recommendations for adjuvant radiotherapy. Strahlenther Onkol 180:15–20CrossRefPubMed Hocht S, Hammad R, Thiel HJ et al. (2004) Recurrent rectal cancer within the pelvis. A multicenter analysis of 123 patients and recommendations for adjuvant radiotherapy. Strahlenther Onkol 180:15–20CrossRefPubMed
18.
Zurück zum Zitat van den BM, Stiggelbout AM, van den Hout WB et al. (2004) Clinical nature and prognosis of locally recurrent rectal cancer after total mesorectal excision with or without preoperative radiotherapy. J Clin Oncol 22:3958–3964CrossRefPubMed van den BM, Stiggelbout AM, van den Hout WB et al. (2004) Clinical nature and prognosis of locally recurrent rectal cancer after total mesorectal excision with or without preoperative radiotherapy. J Clin Oncol 22:3958–3964CrossRefPubMed
19.
Zurück zum Zitat Kapiteijn E, Marijnen CA, Nagtegaal ID et al. (2001) Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 345:638–646CrossRefPubMed Kapiteijn E, Marijnen CA, Nagtegaal ID et al. (2001) Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 345:638–646CrossRefPubMed
20.
Zurück zum Zitat Reerink O, Mulder NH, Botke G et al. (2004) Treatment of locally recurrent rectal cancer, results and prognostic factors. Eur J Surg Oncol 30:954–958 Reerink O, Mulder NH, Botke G et al. (2004) Treatment of locally recurrent rectal cancer, results and prognostic factors. Eur J Surg Oncol 30:954–958
21.
Zurück zum Zitat Hahnloser D, Nelson H, Gunderson L et al. (2003) Curative potential of multimodality therapy for locally recurrent rectal cancer. Ann Surg 237:502–508PubMed Hahnloser D, Nelson H, Gunderson L et al. (2003) Curative potential of multimodality therapy for locally recurrent rectal cancer. Ann Surg 237:502–508PubMed
22.
Zurück zum Zitat Sauer R, Becker H, Hohenberger W et al. (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351:1731–1740PubMed Sauer R, Becker H, Hohenberger W et al. (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351:1731–1740PubMed
23.
Zurück zum Zitat Mohiuddin M, Marks GM, Lingareddy V, Marks J (1997) Curative surgical resection following reirradiation for recurrent rectal cancer. Int J Radiat Oncol Biol Phys 39:643–649CrossRefPubMed Mohiuddin M, Marks GM, Lingareddy V, Marks J (1997) Curative surgical resection following reirradiation for recurrent rectal cancer. Int J Radiat Oncol Biol Phys 39:643–649CrossRefPubMed
24.
Zurück zum Zitat Wiig JN, Poulsen JP, Tveit KM, Olsen DR, Giercksky KE (2000) Intra-operative irradiation (IORT) for primary advanced and recurrent rectal cancer: a need for randomised studies. Eur J Cancer 36:868–874CrossRefPubMed Wiig JN, Poulsen JP, Tveit KM, Olsen DR, Giercksky KE (2000) Intra-operative irradiation (IORT) for primary advanced and recurrent rectal cancer: a need for randomised studies. Eur J Cancer 36:868–874CrossRefPubMed
25.
Zurück zum Zitat Shaw EG, Gunderson LL, Martin JK et al. (1990) Peripheral nerve and ureteral tolerance to intraoperative radiation therapy: clinical and dose-response analysis. Radiother Oncol 18:247–255PubMed Shaw EG, Gunderson LL, Martin JK et al. (1990) Peripheral nerve and ureteral tolerance to intraoperative radiation therapy: clinical and dose-response analysis. Radiother Oncol 18:247–255PubMed
26.
Zurück zum Zitat Hoffman JP, Riley L, Carp NZ, Litwin S (1993) Isolated locally recurrent rectal cancer: a review of incidence, presentation, and management. Semin Oncol 20:506–519PubMed Hoffman JP, Riley L, Carp NZ, Litwin S (1993) Isolated locally recurrent rectal cancer: a review of incidence, presentation, and management. Semin Oncol 20:506–519PubMed
27.
Zurück zum Zitat Berven E. Radiologic treatment of cancer of the rectum. Acta Radiol 1939; 20:373–390 Berven E. Radiologic treatment of cancer of the rectum. Acta Radiol 1939; 20:373–390
28.
Zurück zum Zitat Hayashi M, Shirai Y, Hatakeyama K (1997) Complete remission after radiotherapy for recurrent rectal cancer. Hepatogastroenterology 44:1612–1613PubMed Hayashi M, Shirai Y, Hatakeyama K (1997) Complete remission after radiotherapy for recurrent rectal cancer. Hepatogastroenterology 44:1612–1613PubMed
29.
Zurück zum Zitat Engenhart R, Kimmig B, Hover KH et al. (1990) Photon-neutron therapy for recurrent colorectal cancer — follow up and preliminary results. Strahlenther Onkol 166:95–98PubMed Engenhart R, Kimmig B, Hover KH et al. (1990) Photon-neutron therapy for recurrent colorectal cancer — follow up and preliminary results. Strahlenther Onkol 166:95–98PubMed
30.
Zurück zum Zitat Flentje M, Frey M, Kuttig H, Kimmig B (1988) Radiotherapy of locally recurring colorectal tumors. Prognostic factors, follow-up diagnosis and results. Strahlenther Onkol 164:402–407PubMed Flentje M, Frey M, Kuttig H, Kimmig B (1988) Radiotherapy of locally recurring colorectal tumors. Prognostic factors, follow-up diagnosis and results. Strahlenther Onkol 164:402–407PubMed
31.
Zurück zum Zitat Juffermans JH, Hanssens PE, van Putten WL, van Rhoon GC, van Der ZJ (2003) Reirradiation and hyperthermia in rectal carcinoma: a retrospective study on palliative effect. Chirurg 98:1759–1766 Juffermans JH, Hanssens PE, van Putten WL, van Rhoon GC, van Der ZJ (2003) Reirradiation and hyperthermia in rectal carcinoma: a retrospective study on palliative effect. Chirurg 98:1759–1766
32.
Zurück zum Zitat Mohiuddin M, Marks G, Marks J (2002) Long-term results of reirradiation for patients with recurrent rectal carcinoma. Chirurg 95:1144–1150 Mohiuddin M, Marks G, Marks J (2002) Long-term results of reirradiation for patients with recurrent rectal carcinoma. Chirurg 95:1144–1150
33.
Zurück zum Zitat van den BM, Stiggelbout AM, van den Hout WB et al. (2004) Clinical nature and prognosis of locally recurrent rectal cancer after total mesorectal excision with or without preoperative radiotherapy. J Clin Oncol 22:3958–3964CrossRefPubMed van den BM, Stiggelbout AM, van den Hout WB et al. (2004) Clinical nature and prognosis of locally recurrent rectal cancer after total mesorectal excision with or without preoperative radiotherapy. J Clin Oncol 22:3958–3964CrossRefPubMed
34.
Zurück zum Zitat Rau B, Wust P, Tilly W et al. (2000) Preoperative radiochemotherapy in locally advanced or recurrent rectal cancer: regional radiofrequency hyperthermia correlates with clinical parameters. Int J Radiat Oncol Biol Phys 48:381–391 Rau B, Wust P, Tilly W et al. (2000) Preoperative radiochemotherapy in locally advanced or recurrent rectal cancer: regional radiofrequency hyperthermia correlates with clinical parameters. Int J Radiat Oncol Biol Phys 48:381–391
35.
Zurück zum Zitat Dahl O, Horn A, Morild I et al. (1990) Low-dose preoperative radiation postpones recurrences in operable rectal cancer. Ruslts of a randomized multicenter trial in western Norway. Chirurg 66:2286–2294 Dahl O, Horn A, Morild I et al. (1990) Low-dose preoperative radiation postpones recurrences in operable rectal cancer. Ruslts of a randomized multicenter trial in western Norway. Chirurg 66:2286–2294
36.
Zurück zum Zitat Horn A, Halvorsen JF, Dahl O (1990) Preoperative radiotherapy in operable rectal cancer. Dis Colon Rectum 33:823–828PubMed Horn A, Halvorsen JF, Dahl O (1990) Preoperative radiotherapy in operable rectal cancer. Dis Colon Rectum 33:823–828PubMed
37.
Zurück zum Zitat Goldberg PA, Nicholls RJ, Porter NH, Love S, Grimsey JE (1994) Long-term results of a randomised trial of short-course low-dose adjuvant pre-operative radiotherapy for rectal cancer: reduction in local treatment failure [see comments]. Eur J Cancer 30A:1602–1606 Goldberg PA, Nicholls RJ, Porter NH, Love S, Grimsey JE (1994) Long-term results of a randomised trial of short-course low-dose adjuvant pre-operative radiotherapy for rectal cancer: reduction in local treatment failure [see comments]. Eur J Cancer 30A:1602–1606
38.
Zurück zum Zitat Holm T, Cedermark B, Rutqvist LE (1994) Local recurrence of rectal adenocarcinoma after „curative“ surgery with and without preoperative radiotherapy. Br J Surg 81:452–455PubMed Holm T, Cedermark B, Rutqvist LE (1994) Local recurrence of rectal adenocarcinoma after „curative“ surgery with and without preoperative radiotherapy. Br J Surg 81:452–455PubMed
39.
Zurück zum Zitat Cedermark B, Johansson H, Rutqvist LE, Wilking N (1995) The Stockholm I trial of preoperative short term radiotherapy in operable rectal carcinoma. A prospective randomized trial. Stockholm Colorectal Cancer Study Group. Cancer 75:2269–2275 Cedermark B, Johansson H, Rutqvist LE, Wilking N (1995) The Stockholm I trial of preoperative short term radiotherapy in operable rectal carcinoma. A prospective randomized trial. Stockholm Colorectal Cancer Study Group. Cancer 75:2269–2275
40.
Zurück zum Zitat Stockholm Rectal Cancer Study Group (1990) Preoperative short-term radiation therapy in operable rectal carcinoma. A prospective randomized trial. Chirurg 66:49–55 Stockholm Rectal Cancer Study Group (1990) Preoperative short-term radiation therapy in operable rectal carcinoma. A prospective randomized trial. Chirurg 66:49–55
41.
Zurück zum Zitat Holm T, Rutqvist LE, Johansson H, Cedermark B (1996) Postoperative mortality in rectal cancer treated with or without preoperative radiotherapy: causes and risk factors. Br J Surg 83:964–968PubMed Holm T, Rutqvist LE, Johansson H, Cedermark B (1996) Postoperative mortality in rectal cancer treated with or without preoperative radiotherapy: causes and risk factors. Br J Surg 83:964–968PubMed
42.
Zurück zum Zitat Stockholm Colorectal Cancer Study Group (1996) Randomized study on preoperative radiotherapy in rectal carcinoma. Stockholm Colorectal Cancer Study Group [see comments]. Ann Surg Oncol 3:423–430 Stockholm Colorectal Cancer Study Group (1996) Randomized study on preoperative radiotherapy in rectal carcinoma. Stockholm Colorectal Cancer Study Group [see comments]. Ann Surg Oncol 3:423–430
43.
Zurück zum Zitat Medical Research Council Rectal Cancer Working Party (1996) Randomised trial of surgery alone versus surgery followed by radiotherapy for mobile cancer of the rectum. Lancet 348:1610–1614CrossRefPubMed Medical Research Council Rectal Cancer Working Party (1996) Randomised trial of surgery alone versus surgery followed by radiotherapy for mobile cancer of the rectum. Lancet 348:1610–1614CrossRefPubMed
44.
Zurück zum Zitat Pahlman L (1993) Initial report from a Swedish multicentre study examining the role of preoperative irradiation in the treatment of patients with resectable rectal carcinoma. Br J Surg 80:1333–1336PubMed Pahlman L (1993) Initial report from a Swedish multicentre study examining the role of preoperative irradiation in the treatment of patients with resectable rectal carcinoma. Br J Surg 80:1333–1336PubMed
45.
Zurück zum Zitat Swedish Rectal Cancer Trial (1997) Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med 336:980–987CrossRefPubMed Swedish Rectal Cancer Trial (1997) Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med 336:980–987CrossRefPubMed
46.
Zurück zum Zitat Hahnloser D, Wolff BG, Larson DW, Ping J, Nivatvongs S (2005) Immediate Radical Resection After Local Excision of Rectal Cancer: An Oncologic Compromise? Dis Colon Rectum 48:429–437CrossRefPubMed Hahnloser D, Wolff BG, Larson DW, Ping J, Nivatvongs S (2005) Immediate Radical Resection After Local Excision of Rectal Cancer: An Oncologic Compromise? Dis Colon Rectum 48:429–437CrossRefPubMed
47.
Zurück zum Zitat Nuyttens JJ, Kolkman-Deurloo IK, Vermaas M et al. (2004) High-dose-rate intraoperative radiotherapy for close or positive margins in patients with locally advanced or recurrent rectal cancer. Int J Radiat Oncol Biol Phys 58:106–112 Nuyttens JJ, Kolkman-Deurloo IK, Vermaas M et al. (2004) High-dose-rate intraoperative radiotherapy for close or positive margins in patients with locally advanced or recurrent rectal cancer. Int J Radiat Oncol Biol Phys 58:106–112
48.
Zurück zum Zitat Bakx R, van Tinteren H, van Lanschot JJ, Zoetmulder FA (2004) Surgical treatment of locally recurrent rectal cancer. Eur J Surg Oncol 30:857–863 Bakx R, van Tinteren H, van Lanschot JJ, Zoetmulder FA (2004) Surgical treatment of locally recurrent rectal cancer. Eur J Surg Oncol 30:857–863
49.
Zurück zum Zitat Gonzalez RJ, McCarter MD, McDermott T, Pearlman NW (2003) Transsacral exenteration of fixed primary and recurrent anorectal cancer. Am J Surg 186:670–674CrossRefPubMed Gonzalez RJ, McCarter MD, McDermott T, Pearlman NW (2003) Transsacral exenteration of fixed primary and recurrent anorectal cancer. Am J Surg 186:670–674CrossRefPubMed
50.
Zurück zum Zitat Garcia-Aguilar J, Cromwell JW, Marra C et al. Treatment of locally recurrent rectal cancer. Dis Colon Rectum 2001; 44:1743–1748 Garcia-Aguilar J, Cromwell JW, Marra C et al. Treatment of locally recurrent rectal cancer. Dis Colon Rectum 2001; 44:1743–1748
51.
Zurück zum Zitat Salo JC, Paty PB, Guillem J et al. (1999) Surgical salvage of recurrent rectal carcinoma after curative resection: a 10-year experience. Ann Surg Oncol 6:171–177 Salo JC, Paty PB, Guillem J et al. (1999) Surgical salvage of recurrent rectal carcinoma after curative resection: a 10-year experience. Ann Surg Oncol 6:171–177
52.
Zurück zum Zitat Wong CS, Cummings BJ, Brierley JD et al. (1998) Treatment of locally recurrent rectal carcinoma — results and prognostic factors. Int J Radiat Oncol Biol Phys 40:427–435PubMed Wong CS, Cummings BJ, Brierley JD et al. (1998) Treatment of locally recurrent rectal carcinoma — results and prognostic factors. Int J Radiat Oncol Biol Phys 40:427–435PubMed
53.
Zurück zum Zitat Suzuki K, Gunderson LL, Devine RM et al. (1995) Intraoperative irradiation after palliative surgery for locally recurrent rectal cancer. Chirurg 75:939–952 Suzuki K, Gunderson LL, Devine RM et al. (1995) Intraoperative irradiation after palliative surgery for locally recurrent rectal cancer. Chirurg 75:939–952
Metadaten
Titel
Therapieprinzipien beim Lokalrezidiv des Rektumkarzinoms
verfasst von
PD Dr. B. Rau
S. Koswig
B. Gebauer
B. Hildebrandt
J. Gellermann
Publikationsdatum
01.08.2005
Verlag
Springer-Verlag
Erschienen in
Die Onkologie / Ausgabe 8/2005
Print ISSN: 2731-7226
Elektronische ISSN: 2731-7234
DOI
https://doi.org/10.1007/s00761-005-0905-6

Weitere Artikel der Ausgabe 8/2005

Der Onkologe 8/2005 Zur Ausgabe

Journal-Club

Journal Club 8/05

Onkologie im Internet

Webadressen zum Rektumkarzinom

Neu im Fachgebiet Onkologie

Verkürzte MRT bei dichtem Brustgewebe: Was bringen sequenzielle Scans?

21.07.2024 Mamma-MRT Nachrichten

Frauen mit dichtem Brustgewebe könnten zusätzlich zum regulären Mammografie-Screening von sequenziellen MRT-Untersuchungen mit verkürztem Protokoll (AB-MRT) profitieren, schlagen US-Radiologen vor.

Informierte Frauen neigen zu späterem Mammografie-Screening

Frauen in ihren 40ern, die über die Vor- und Nachteile des Mammografie-Screenings auf Brustkrebs informiert werden, neigen stärker dazu, den Screeningbeginn nach hinten zu verschieben. Die Mehrheit aber nähme das Angebot an, wie eine US-Studie zeigt.

Endometriose-Subtypen und das Risiko für Ovarialkarzinome

19.07.2024 Ovarialkarzinom Nachrichten

US-Kohortendaten sprechen dafür, dass verschiedene Endometrioseformen unterschiedlich mit dem Risiko für Ovarialkarzinome assoziiert sind. Besonders erhöht ist das Risiko offenbar bei tief infiltrierenden und ovariellen Endometrioseformen.

Die zelluläre Differenzierung wird wiederhergestellt

18.07.2024 Akute myeloische Leukämie Nachrichten

Ivosidenib von Servier ist ein Inhibitor der mutierten Isoform der Isocitrat-Dehydrogenase-1 (IDH1) und wird zur Behandlung von Patientinnen und Patienten mit neu diagnostizierter akuter myeloischer Leukämie (AML) eingesetzt. Die Substanz sorgt für die Wiederherstellung der zellulären Differenzierung.

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.