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9882 Suchergebnisse für:

Simvastatin 

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  1. Open Access 01.12.2024 | OriginalPaper

    Anti-inflammatory potential of simvastatin and amfenac in ARPE-19 cells; insights in preventing re-detachment and proliferative vitreoretinopathy after rhegmatogenous retinal detachment surgery

    Rhegmatogenous retinal detachment (RRD) surgery is one of the most common vitreoretinal operations, and ca. 10% of patients need re-surgery due to the re-detachment of the retina [ 1 – 3 ]. RRD can develop into proliferative vitreoretinopathy (PVR) …

  2. 01.04.2024 | OriginalPaper

    Immediately placed implants using simvastatin and autogenous tooth graft combination in periodontally compromised sites: a randomized controlled clinical trial

    Periodontal disease is accompanied by the destruction of hard and/or soft tissues around the affected tooth which results in tooth loss [ 1 ]. Implant dentistry is a long-term noble way for the prosthetic rehabilitation of partially edentulous …

  3. Open Access 23.01.2024 | OriginalPaper

    Simvastatin Significantly Reduced Alcohol-Induced Cardiac Damage in Adolescent Mice

    Alcohol abuse by adolescents is becoming a serious health concern as they often progress to becoming alcoholics later in life which may lead to heart problems. Chronic alcohol use alters the cardiac function and structure, such as haemodynamic …

  4. 01.01.2024 | ReviewPaper

    Effect of simvastatin topical use on alveolar bone after tooth extraction: a scoping review

    After tooth loss, alveolar bone healing begins, which triggers a series of cellular events that can lead to tissue atrophy. Alveolar bone remodeling, also known as residual ridge resorption (RRR), is considered chronic, cumulative, progressive …

  5. Open Access 01.01.2024 | OriginalPaper

    Enhanced therapeutic efficacy of doxorubicin/cyclophosphamide in combination with pitavastatin or simvastatin against breast cancer cells

    Fighting breast tumors mandates finding different agents devoid of chemotherapy side effects. Repurposing existing drugs, such as statins, presents a promising avenue for the development of novel cancer therapeutics. Based on the different effects …

  6. 01.01.2024 | OriginalPaper

    Alveolar ridge splitting and simvastatin loaded xenograft for guided bone regeneration and simultaneous implant placement: randomized controlled clinical trial

    Dental implants are commonly employed for oral rehabilitation in case of either partial or total edentulous jaws. Adequate quantity and quality of both hard and soft tissues are needed to accomplish ideal outcomes in implant dentistry. There is a …

  7. Open Access 17.10.2023 | OriginalPaper

    Simvastatin Preferentially Targets FLT3/ITD Acute Myeloid Leukemia by Inhibiting MEK/ERK and p38-MAPK Signaling Pathways

    Acute myeloid leukemia (AML) is a type of clonal malignant proliferative disease of hematopoietic myeloid blasts. The prognosis remains poor in pediatric and adult patients, with 5-year survival rates approximating 66–68% and 10–20%, respectively …

  8. Open Access 01.12.2023 | OriginalPaper

    Mutant p53 murine oviductal epithelial cells induce progression of high-grade serous carcinoma and are most sensitive to simvastatin therapy in vitro and in vivo

    High-grade serous carcinoma (HGSC) is the most common and aggressive subtype of epithelial ovarian cancer, characterized by gain-of-function TP53 mutations originating in the fallopian tube epithelium. Therapeutic intervention occurs at advanced …

  9. 24.04.2023 | Parkinson-Krankheit | ReviewPaper
    Parkinson-Krankheit

    Simvastatin kann das Fortschreiten der Parkinson-Krankheit nicht bremsen

  10. 01.06.2023 | News

    Simvastatin

    Statin-induced necrotizing autoimmune myositis: case report
  11. 22.05.2023 | OriginalPaper

    Baseline Severity and Inflammation Would Influence the Effect of Simvastatin on Clinical Outcomes in Cirrhosis Patients

    Inflammation is a physiological response usually triggered by infection or tissue injury, followed by resolution, an essential step to preserve local organ and systemic homeostasis [ 1 ]. The trouble with inflammation is not how frequently it …

  12. 10.04.2023 | OriginalPaper

    New insights on mode of action of vasorelaxant activity of simvastatin

    Simvastatin is a semisynthetic inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and is used extensively to treat atherosclerotic cardiovascular disease. Apart from the lipid-lowering effect, simvastatin has been documented to …

  13. 01.03.2023 | News

    Simvastatin

    Immune-mediated necrotising myositis: case report
  14. Open Access 21.09.2022 | OriginalPaper

    Modulation of radiosensitivity of DU145 prostate carcinoma cells by simvastatin

    Prostate cancer is the most common malignant neoplasia of men and a common cause of cancer-related death. It is predominantly a disease of older men, who frequently have the need for lipid-lowering therapy—predominantly statin therapy—to reduce …

  15. 01.06.2022 | OriginalPaper

    Efficacy of simvastatin in bone regeneration after surgical removal of mandibular third molars

    Bony defect augmentation following surgical or trauma-related injuries remains a challenge in maxillofacial reconstruction. Bone is a biologically privileged tissue which heals by regeneration rather than repair [ 6 ]. It is regulated by a series …

  16. 01.03.2023 | News

    Simvastatin

    Rhabdomyolysis : case report
  17. 14.05.2022 | OriginalPaper

    Simvastatin, but Not Atorvastatin, Is Associated with Higher Peak Rivaroxaban Serum Levels and Bleeding: an Asian Cohort Study from Singapore

    Direct oral anticoagulants (DOACs) are mainstay drugs in anticoagulation therapy for non-valvular atrial fibrillation (NVAF), the most prevalent form of atrial fibrillation (AF) [ 1 ]. NVAF is associated with a five-fold increased risk of ischemic …

  18. 25.08.2021 | Hypercholesterinämie | ReviewPaper
    Therapie der Hypercholesterinämie mit Statinen

    Prädiktoren für die Entwicklung einer Myopathie unter Simvastatin

    Statine können in sehr seltenen Fällen von einer Myopathie bis hin zur Rhabdomyolyse führen. In Deutschland und in Europa wird am häufigsten Simvastatin verordnet. Lassen sich Risikofaktoren für eine statininduzierte Myopathie identifizieren?

  19. Open Access 01.12.2021 | OriginalPaper

    Simvastatin impairs hippocampal synaptic plasticity and cognitive function in mice

    Lipophilic statins which are blood brain barrier (BBB) permeable are speculated to affect the cholesterol synthesis and neural functions in the central nervous system. However, whether these statins can affect cholesterol levels and synaptic …

  20. 01.12.2021 | OriginalPaper

    Simvastatin Blocks Reinstatement of Cocaine-induced Conditioned Place Preference in Male Mice with Brain Lipidome Remodeling

    Drug-associated reward memories are conducive to intense craving and often trigger relapse. Simvastatin has been shown to regulate lipids that are involved in memory formation but its influence on other cognitive processes is elusive. Here, we …

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