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Zika-Virus 

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  1. Open Access 01.12.2024 | OriginalPaper

    Repurposing of Zika virus live-attenuated vaccine (ZIKV-LAV) strains as oncolytic viruses targeting human glioblastoma multiforme cells

    Glioblastoma multiforme (GBM) is the most common malignant primary brain cancer affecting the adult population. Median overall survival for GBM patients is poor (15 months), primarily due to high rates of tumour recurrence and the paucity of …

  2. Open Access 01.12.2024 | OriginalPaper

    Detecting the impacts of humidity, rainfall, temperature, and season on chikungunya, dengue and Zika viruses in Aedes albopictus mosquitoes from selected sites in Cebu city, Philippines

    While Aedes aegypti (Linnaeus) is the main vector of arboviruses such as chikungunya (CHIKV), dengue (DENV), and Zika (ZIKV), Aedes albopictus (Skuse), the Asian tiger mosquito, plays also a role in its prevalent arboviral transmission to humans [ …

  3. 01.02.2024 | OriginalPaper

    Zika virus infection during pregnancy and vertical transmission: case reports and peptide-specific cell-mediated immune responses

    Zika virus (ZIKV) infection in pregnant women is associated with birth defects, which are more prevalent and severe the earlier in pregnancy the infection occurs. Pregnant women at risk of possible ZIKV exposure (n = 154) were screened using ELISA …

  4. 29.08.2023 | Erratum

    Correction: Knowledge, Attitudes and Practices About Zika Virus Infection Among Women of Reproductive Age in Central Brooklyn, New York City, USA

  5. 28.07.2023 | OriginalPaper

    Knowledge, Attitudes and Practices About Zika Virus Infection Among Women of Reproductive Age in Central Brooklyn, New York City, USA

    Zika virus (ZIKV) is spread by mosquitos, sexual intercourse and vertically during pregnancy. The 2015–2016 ZIKV epidemic infected millions in the Americas and resulted in thousands of infants born with malformations. Though the clusters of severe …

  6. Open Access 01.12.2023 | OriginalPaper

    Interactions between DC-SIGN and the envelope protein from Dengue and Zika viruses: a structural perspective based on molecular dynamics and MM/GBSA analyses

    Zika virus (ZIKV) and dengue virus (DENV) share a lot of similarities being both phylogenetically closely related, share the same insect vector passage for reaching the host, affinity for the same carbohydrate receptor domains (CRDs), indicating …

  7. Open Access 01.12.2023 | OriginalPaper

    Production of a chimeric flavivirus that contains the major structural glycoprotein genes of T’Ho virus in the genetic background of Zika virus

    T’Ho virus is a poorly characterized orthoflavivirus most closely related to Rocio virus and Ilheus virus, two orthoflaviviruses associated with human disease, suggesting that T’Ho virus could also be a human pathogen. The genome of T’Ho virus has …

  8. Open Access 01.12.2023 | OriginalPaper

    Organotypic hippocampal culture model reveals differential responses to highly similar Zika virus isolates

    Zika virus (ZIKV) is an arbovirus of the Flaviviridae family, transmitted primarily through the bite of the Aedes aegypti mosquito. Infected individuals are usually asymptomatic or oligosymptomatic [ 1 ]. In 2015, Brazil faced an epidemic of Zika

  9. Open Access 01.12.2023 | OriginalPaper

    Investigation of the activity of baicalein towards Zika virus

    Zika virus (ZIKV), a human pathogenic virus transmitted by Aedes ( Ae .) species mosquitoes is classified as belonging to the genus Flavivirus , a part of the family Flaviviridae , together with closely related viruses such as dengue virus (DENV) …

  10. 01.08.2023 | BriefCommunication

    5'/3' RACE method for sequencing the 5' and 3' untranslated regions of Zika virus

    The spread of Zika virus (ZIKV) from the African continent to the Americas promoted its molecular evolution, as reflected by mutations in its RNA genome. Most of the ZIKV genome sequences in the GenBank database have incomplete 5' and 3' UTR …

  11. Open Access 01.12.2023 | OriginalPaper

    Interaction of the Zika virus with the cytoplasmic dynein-1

    Zika virus (ZIKV) infection is a major public health threat, making the study of its biology a matter of great importance. By analyzing the viral–host protein interactions, new drug targets may be proposed. In this work, we showed that human …

  12. Open Access 01.12.2023 | OriginalPaper

    Metabolic reprogramming and lipid droplets are involved in Zika virus replication in neural cells

    Zika virus (ZIKV) infection is a global public health concern linked to adult neurological disorders and congenital diseases in newborns. Host lipid metabolism, including lipid droplet (LD) biogenesis, has been associated with viral replication …

  13. Open Access 06.04.2023 | OriginalPaper

    Zika virus infection of retinal cells and the developing mouse eye induces host responses that contrasts to the brain and dengue virus infection

    Zika virus (ZIKV) infection causes ocular and neurological pathologies with ZIKV-induction of developmental abnormalities following in utero infection a major concern. The study here has compared ZIKV and the related dengue virus (DENV) infection …

  14. Open Access 01.12.2022 | OriginalPaper

    Zika virus vertical transmission in interferon receptor1-antagonized Rag1−/− mice results in postnatal brain abnormalities and clinical disease

    The mechanisms by which vertically transmitted Zika virus (ZIKV) causes postnatal brain development abnormalities and congenital disease remain poorly understood. Here, we optimized the established anti-IFNAR1 treated, Rag1−/− (AIR) mouse model of …

  15. 01.04.2023 | OriginalPaper

    Unravelling the epidemiological diversity of Zika virus by analyzing key protein variations

    The consequences of Zika virus (ZIKV) infections were limited to sporadic mild diseases until almost a decade ago, when epidemic outbreaks took place, with quick spread into the Americas. Simultaneously, novel severe neurological manifestations of …

  16. Open Access 01.12.2021 | OriginalPaper

    Zika virus induces neuronal and vascular degeneration in developing mouse retina

    Zika virus (ZIKV), a mosquito-borne flavivirus, can cause severe eye disease and even blindness in newborns. However, ZIKV-induced retinal lesions have not been studied in a comprehensive way, mechanisms of ZIKV-induced retinal abnormalities are …

  17. 01.02.2023 | OriginalPaper

    MEK/ERK activation plays a decisive role in Zika virus morphogenesis and release

    Brazil has experienced an increase in outbreaks caused by flaviviruses. The high incidence of dengue fever, the morbidity of Zika in children, and the high mortality of yellow fever have affected millions in recent years. Deciphering host-virus

  18. 01.02.2023 | OriginalPaper

    Differential proteomics of Zika virus (ZIKV) infection reveals molecular changes potentially involved in immune system evasion by a Brazilian strain of ZIKV

    Zika virus (ZIKV) is an arbovirus that was responsible for multiple outbreaks from 2007 to 2015. It has been linked to cases of microcephaly in Brazil in 2015, among other neurological disorders. Differences among strains might be the reason for …

  19. Open Access 09.11.2022 | OriginalPaper

    TSPO expression in a Zika virus murine infection model as an imaging target for acute infection-induced neuroinflammation

    Zika virus (ZIKV) is a neurotropic virus, and human infection often results in neuroinflammation with devastating neurologic consequences. It is a member of the Flaviviridae family of positive-sense, single-stranded RNA genome viruses that was …

  20. Open Access 01.12.2022 | OriginalPaper

    Congenital anomalies during the 2015–2018 Zika virus epidemic: a population-based cross-sectional study

    Congenital anomalies are a set of functional and morphological abnormalities occurring during embryonic development due to several etiologies [ 1 – 4 ]. Approximately 65% of congenital anomalies have unknown causes, 25% have genetic causes, and 10% …

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