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Erschienen in:

2017 | OriginalPaper | Buchkapitel

7. Transplantationsimmunologische Aspekte

verfasst von : Volker Daniel

Erschienen in: Fehlgeburten Totgeburten Frühgeburten

Verlag: Springer Berlin Heidelberg

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Zusammenfassung

Bei einer normalen Schwangerschaft besteht eine Toleranz des maternalen Immunsystems gegen die fremden fetalen Gewebemerkmale. Wird diese Toleranz durch verschiedene immunologische Faktoren herabgesetzt, können Schwangerschaftskomplikationen auftreten. So gibt es z.B. Hinweise aus der Forschung, dass ein Teil der rezidivierenden Spontanaborte durch immunologische Abstoßungsreaktionen gegen die paternalen Fremdantigene verursacht wird.

Abumaree MH, Chamley LW, Badri M, El-Muzaini MF (2012) Trophoblast debris modulates the expression of immune proteins in macrophages: a key to maternal tolerance of the fetal allograft? Journal of Reproductive Immunology 94(2): 131–141PubMedCrossRef

Ariga H, Ohto H, Busch MP, Imamura S, Watson R, Reed W, Lee TH (2001) Kinetics of fetal cellular and cell-free DNA in the maternal circulation during and after pregnancy: implications for noninvasive prenatal diagnosis. Transfusion 41(12): 1524–1530PubMedCrossRef

Bianchi DW, Zickwolf GK, Weil GJ, Sylvester S, DeMaria MA (1996) Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proceedings of the National Academy of Sciences of the United States of America 93(2): 705–708PubMedPubMedCentralCrossRef

Bouma GJ, van Caubergh P, van Bree SP, Castelli-Visser RM, Witvliet MD, van der Meer-Prins EM, van Rood JJ, Claas FH (1996) Pregnancy can induce priming of cytotoxic T lymphocytes specific for paternal HLA antigens that is associated with antibody formation. Transplantation 62(5): 672–678PubMedCrossRef

Buurma A, Cohen D, Veraar K, Schonkeren D, Claas FH, Bruijn JA, Bloemenkamp KW, Baelde HJ (2012) Preeclampsia is characterized by placental complement dysregulation. Hypertension 60(5): 1332–1337PubMedCrossRef

Dahl M, Hviid TV (2012) Human leucocyte antigen class Ib molecules in pregnancy success and early pregnancy loss. Human Reproduction Update 18(1): 92–109PubMedCrossRef

Dankers MK, Roelen DL, Korfage N, de Lange P, Witvliet M, Sandkuijl L, Doxiadis, II, Claas FH (2003) Differential immunogenicity of paternal HLA Class I antigens in pregnant women. Human Immunology 64(6): 600–606PubMedCrossRef

Dankers MK, Witvliet MD, Roelen DL, de Lange P, Korfage N, Persijn GG, Duquesnoy R, Doxiadis II, Claas FH (2004) The number of amino acid triplet differences between patient and donor is predictive for the antibody reactivity against mismatched human leukocyte antigens. Transplantation 77(8): 1236–1239PubMedCrossRef

Duquesnoy RJ (2012) The antibody response to an HLA mismatch: a model for nonself-self discrimination in relation to HLA epitope immunogenicity. International Journal of Immunogenetics 39(1): 1–9PubMedCrossRef

Feinman MA, Kliman HJ, Main EK (1987) HLA antigen expression and induction by gamma-interferon in cultured human trophoblasts. American Journal of Obstetrics and Gynecology 157(6): 1429–1434PubMedCrossRef

Fernandez N, Cooper J, Sprinks M, Abdelrahman M, Fiszer D, Kurpisz M, Dealtry G (1999) A critical review of the role of the major histocompatibility complex in fertilization, preimplantation development and feto-maternal interactions. Human Reproduction Update 5(3): 234–248PubMedCrossRef

Germain SJ, Sacks GP, Sooranna SR, Sargent IL, Redman CW (2007) Systemic inflammatory priming in normal pregnancy and preeclampsia: the role of circulating syncytiotrophoblast microparticles. Journal of Immunology 178(9): 5949–5956CrossRef

Hammer A, Hutter H, Blaschitz A, Mahnert W, Hartmann M, Uchanska-Ziegler B, Ziegler A, Dohr G (1997) Amnion epithelial cells, in contrast to trophoblast cells, express all classical HLA class I molecules together with HLA-G. American Journal of Reproductive Immunology 37(2): 161–171PubMedCrossRef

Hiby SE, Apps R, Sharkey AM, Farrell LE, Gardner L, Mulder A, Claas FH, Walker JJ, Redman CW, Morgan L et al. (2010) Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2. Journal of Clinical Investigation 120(11): 4102–4110PubMedPubMedCentralCrossRef

Hiby SE, Regan L, Lo W, Farrell L, Carrington M, Moffett A (2008) Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage. Human Reproduction 23(4): 972–976PubMedCrossRef

Hiby SE, Walker JJ, O'Shaughnessy K M, Redman CW, Carrington M, Trowsdale J, Moffett A (2004) Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. The Journal of Experimental Medicine 200(8): 957–965PubMedPubMedCentralCrossRef

Hviid TV, Hylenius S, Rorbye C, Nielsen LG (2003) HLA-G allelic variants are associated with differences in the HLA-G mRNA isoform profile and HLA-G mRNA levels. Immunogenetics 55(2): 63–79PubMed

Jacob S, McClintock MK, Zelano B, Ober C (2002) Paternally inherited HLA alleles are associated with women's choice of male odor. Nature Genetics 30(2): 175–179PubMedCrossRef

Jenkins C, Roberts J, Wilson R, MacLean MA, Shilito J, Walker JJ (2000) Evidence of a T(H) 1 type response associated with recurrent miscarriage. Fertility and Sterility 73(6): 1206–1208PubMedCrossRef

Jin LP, Chen QY, Zhang T, Guo PF, Li DJ (2009) The CD4+CD25 bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage. Clinical Immunology 133(3): 402–410PubMedCrossRef

van Kampen CA, Versteeg-van der Voort Maarschalk MF, Langerak-Langerak J, van Beelen E, Roelen DL, Claas FH (2001) Pregnancy can induce long-persisting primed CTLs specific for inherited paternal HLA antigens. Human Immunology 62(3): 201–207PubMedCrossRef

van Kampen CA, Versteeg-van der Voort Maarschalk MF, Langerak-Langerak J, Roelen DL, Claas FH (2002) Kinetics of the pregnancy-induced humoral and cellular immune response against the paternal HLA class I antigens of the child. Human Immunology 63(6): 452–458PubMedCrossRef

van Kampen CA, Versteeg-van der Voort Maarschalk MF, Roelen DL, Claas FH (2002) Primed CTLs specific for HLA class I may still be present in sensitized patients when anti-HLA antibodies have disappeared: relevance for donor selection. Transplantation 73(8): 1286–1290PubMedCrossRef

King KE, Kao KJ, Bray PF, Casella JF, Blakemore K, Callan NA, Kennedy SD, Kickler TS (1996) The role of HLA antibodies in neonatal thrombocytopenia: a prospective study. Tissue Antigens 47(3): 206–211PubMedCrossRef

Laird SM, Tuckerman EM, Cork BA, Linjawi S, Blakemore AI, Li TC (2003) A review of immune cells and molecules in women with recurrent miscarriage. Human Reproduction Update 9(2): 163–174PubMedCrossRef

La Rocca C, Carbone F, Longobardi S, Matarese G (2014) The immunology of pregnancy: regulatory T cells control maternal immune tolerance toward the fetus. Immunol Lett 162(1 Pt A): 41–48PubMedCrossRef

Lashley EE, Meuleman T, Claas FH (2013) Beneficial or harmful effect of antipaternal human leukocyte antibodies on pregnancy outcome? A systematic review and meta-analysis. American Journal of Reproductive Immunology 70(2): 87–103PubMedCrossRef

Lashley LE, van der Hoorn ML, Haasnoot GW, Roelen DL, Claas FH (2014) Uncomplicated oocyte donation pregnancies are associated with a higher incidence of human leukocyte antigen alloantibodies. Human Immunology 75(6): 555–560PubMedCrossRef

Lashley LE, van der Keur C, van Beelen E, Schaap R, van der Westerlaken LA, Scherjon SA, Claas FH (2015) Stronger T-Cell alloreactivity and diminished suppressive capacity of peripheral regulatory T cells in infertile women undergoing in vitro fertilization. American Journal of Reproductive Immunology 74(3): 268–278PubMedCrossRef

Le Bouteiller P, Rodriguez AM, Mallet V, Girr M, Guillaudeux T, Lenfant F (1996) Placental expression of HLA class I genes. American Journal of Reproductive Immunology 35(3): 216–225PubMedCrossRef

Lissauer DM, Piper KP, Moss PA, Kilby MD (2009) Fetal microchimerism: the cellular and immunological legacy of pregnancy. Expert Rev Mol Med 11: e33CrossRef

Marsh SG (2015) Nomenclature for factors of the HLA system, update June 2015. Tissue Antigens 86(3): 234–237PubMedCrossRef

Mei S, Tan J, Chen H, Chen Y, Zhang J (2010) Changes of CD4+CD25high regulatory T cells and FOXP3 expression in unexplained recurrent spontaneous abortion patients. Fertility and Sterility 94(6): 2244–2247PubMedCrossRef

Meuleman T, Lashley LE, Dekkers OM, van Lith JM, Claas FH, Bloemenkamp KW (2015) HLA associations and HLA sharing in recurrent miscarriage: a systematic review and meta-analysis. Human Immunology 76(5): 362–373PubMedCrossRef

Middleton D, Curran M, Maxwell L (2002) Natural killer cells and their receptors. Transplant Immunology 10(2–3): 147–164PubMedCrossRef

Nielsen HS (2011) Secondary recurrent miscarriage and H-Y immunity. Human Reproduction Update 17(4): 558–574PubMedCrossRef

Nielsen HS, Steffensen R, Varming K, Van Halteren AG, Spierings E, Ryder LP, Goulmy E, Christiansen OB (2009) Association of HY-restricting HLA class II alleles with pregnancy outcome in patients with recurrent miscarriage subsequent to a firstborn boy. Hum Mol Genet 18(9): 1684–1691PubMedCrossRef

Nielsen HS, Steffensen R, Lund M, Egestad L, Mortensen LH, Andersen AM, Lidegaard O, Christiansen OB (2010) Frequency and impact of obstetric complications prior and subsequent to unexplained secondary recurrent miscarriage. Human Reproduction 25(6): 1543–1552PubMedCrossRef

Nielsen HS, Witvliet MD, Steffensen R, Haasnoot GW, Goulmy E, Christiansen OB, Claas F (2010) The presence of HLA-antibodies in recurrent miscarriage patients is associated with a reduced chance of a live birth. Journal of Reproductive Immunology 87(1–2): 67–73PubMedCrossRef

Piccinni MP, Beloni L, Livi C, Maggi E, Scarselli G, Romagnani S (1998) Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions. Nature Medicine 4(9): 1020–1024PubMedCrossRef

Popli R, Sahaf B, Nakasone H, Lee JY, Miklos DB (2014) Clinical impact of H-Y alloimmunity. Immunol Res 58(2–3): 249–258PubMedPubMedCentralCrossRef

Regan L, Braude PR, Hill DP (1991) A prospective study of the incidence, time of appearance and significance of anti-paternal lymphocytotoxic antibodies in human pregnancy. Human Reproduction 6(2): 294–298PubMed

Rizzo R, Hviid TV, Govoni M, Padovan M, Rubini M, Melchiorri L, Stignani M, Carturan S, Grappa MT, Fotinidi M et al. (2008) HLA-G genotype and HLA-G expression in systemic lupus erythematosus: HLA-G as a putative susceptibility gene in systemic lupus erythematosus. Tissue Antigens 71(6): 520–529PubMedCrossRef

Rodriguez AM, Mallet V, Lenfant F, Arnaud J, Girr M, Urlinger S, Bensussan A, Le Bouteiller P (1997) Interferon-gamma rescues HLA class Ia cell surface expression in term villous trophoblast cells by inducing synthesis of TAP proteins. European Journal of Immunology 27(1): 45–54PubMedCrossRef

Sargent IL, Borzychowski AM, Redman CW (2006) NK cells and human pregnancy - an inflammatory view. Trends in Immunology 27(9): 399–404PubMedCrossRef

Sasaki Y, Sakai M, Miyazaki S, Higuma S, Shiozaki A, Saito S (2004) Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Molecular Human Reproduction 10(5): 347–353PubMedCrossRef

Scherjon S, Lashley L, van der Hoorn ML, Claas F (2011) Fetus specific T cell modulation during fertilization, implantation and pregnancy. Placenta 32 (suppl 4): S291–297CrossRef

Steinborn A, Varkonyi T, Scharf A, Bahlmann F, Klee A, Sohn C (2007) Early detection of decreased soluble HLA-G levels in the maternal circulation predicts the occurrence of preeclampsia and intrauterine growth retardation during further course of pregnancy. American Journal of Reproductive Immunology 57(4): 277–286PubMedCrossRef

Tanaka T, Umesaki N, Nishio J, Maeda K, Kawamura T, Araki N, Ogita S (2000) Neonatal thrombocytopenia induced by maternal anti-HLA antibodies: a potential side effect of allogenic leukocyte immunization for unexplained recurrent aborters. Journal of Reproductive Immunology 46(1): 51–57PubMedCrossRef

Teles A, Zenclussen AC, Schumacher A (2013) Regulatory T cells are baby's best friends. American Journal of Reproductive Immunology 69(4): 331–339PubMedCrossRef

Thielens A, Vivier E, Romagne F (2012) NK cell MHC class I specific receptors (KIR): from biology to clinical intervention. Current Opinion in Immunology 24(2): 239–245PubMedCrossRef

Tilburgs T, Roelen DL, van der Mast BJ, van Schip JJ, Kleijburg C, de Groot-Swings GM, Kanhai HH, Claas FH, Scherjon SA (2006) Differential distribution of CD4(+)CD25(bright) and CD8(+)CD28(-) T-cells in decidua and maternal blood during human pregnancy. Placenta 27 (suppl A): S47–53CrossRef

Triulzi DJ, Kleinman S, Kakaiya RM, Busch MP, Norris PJ, Steele WR, Glynn SA, Hillyer CD, Carey P, Gottschall JL et al. (2009) The effect of previous pregnancy and transfusion on HLA alloimmunization in blood donors: implications for a transfusion-related acute lung injury risk reduction strategy. Transfusion 49(9): 1825–1835PubMedPubMedCentralCrossRef

Van Rood JJ, Eernisse JG, Van Leeuwen A (1958) Leucocyte antibodies in sera from pregnant women. Nature 181(4625): 1735–1736PubMedCrossRef

Verdijk RM, Kloosterman A, Pool J, van de Keur M, Naipal AM, van Halteren AG, Brand A, Mutis T, Goulmy E (2004) Pregnancy induces minor histocompatibility antigen-specific cytotoxic T cells: implications for stem cell transplantation and immunotherapy. Blood 103(5): 1961–1964PubMedCrossRef

Verduin EP, Schonewille H, Brand A, Haasnoot GW, Claas FH, Lindenburg IT, Lopriore E, Oepkes D, Roelen DL, Doxiadis II (2013) High anti-HLA response in women exposed to intrauterine transfusions for severe alloimmune hemolytic disease is associated with mother-child HLA triplet mismatches, high anti-D titer, and new red blood cell antibody formation. Transfusion 53(5): 939–947PubMedCrossRef

Wilczynski JR (2006) Immunological analogy between allograft rejection, recurrent abortion and pre-eclampsia - the same basic mechanism? Human Immunology 67(7): 492–511PubMedCrossRef

Yang H, Qiu L, Chen G, Ye Z, Lu C, Lin Q (2008) Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients. Fertility and Sterility 89(3): 656–661PubMedCrossRef

Yang H, Qiu L, Di W, Zhao A, Chen G, Hu K, Lin Q (2009) Proportional change of CD4+CD25+ regulatory T cells after lymphocyte therapy in unexplained recurrent spontaneous abortion patients. Fertility and Sterility 92(1): 301–305PubMedCrossRef

Yie SM, Taylor RN, Librach C (2005) Low plasma HLA-G protein concentrations in early gestation indicate the development of preeclampsia later in pregnancy. American Journal of Obstetrics and Gynecology 193(1): 204–208PubMedCrossRef

Zenclussen AC, Hammerling GJ (2015) Cellular regulation of the uterine microenvironment that enables embryo implantation. Frontiers in Immunology 6: 321PubMedPubMedCentralCrossRef

Zhou J, Wang Z, Zhao X, Wang J, Sun H, Hu Y (2012) An increase of Treg cells in the peripheral blood is associated with a better in vitro fertilization treatment outcome. American Journal of Reproductive Immunology 68(2): 100–106PubMedCrossRef

Titel: Transplantationsimmunologische Aspekte
verfasst von: Volker Daniel
Verlag: Springer Berlin Heidelberg
Buch: Fehlgeburten Totgeburten Frühgeburten
Print ISBN: 978-3-662-50423-9

Electronic ISBN: 978-3-662-50424-6

Copyright-Jahr: 2017
DOI: https://doi.org/10.1007/978-3-662-50424-6_7

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7. Transplantationsimmunologische Aspekte

Zusammenfassung

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Hochrisiko-Eingriffe für postoperative Übelkeit

Adjuvante Brustkrebstherapie: Doppelt hält besser

Manche Gestagene können das Risiko für Meningeome erhöhen

Stillende Frauen haben geringeres kardiovaskuläres Risiko

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Zusammenfassung

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Neu im Fachgebiet Gynäkologie und Geburtshilfe

Hochrisiko-Eingriffe für postoperative Übelkeit

Adjuvante Brustkrebstherapie: Doppelt hält besser

Manche Gestagene können das Risiko für Meningeome erhöhen

Stillende Frauen haben geringeres kardiovaskuläres Risiko

Update Gynäkologie