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Head and Neck Pathology

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21.03.2022 | UPDATE FROM THE 5TH EDITION OF THE WORLD HEALTH ORGANIZATION CLASSIFICATION OF HEAD AND NECK TUMORS

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Tumours of the Oral Cavity and Mobile Tongue

verfasst von: Susan Muller, Wanninayake M. Tilakaratne

Erschienen in: Head and Neck Pathology | Ausgabe 1/2022

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Abstract

The fifth chapter of the upcoming fifth edition of the 2022 World Health Organization Classification of Tumours of the Head and Neck titled Tumours of the oral cavity and mobile tongue, has had some modifications from the 2017 fourth edition. A new section "Non-neoplastic Lesions", introduces two new entries: necrotizing sialometaplasia and melanoacanthoma. The combined Oral potentially malignant disorders and Oral epithelial dysplasia section in the 2015 WHO has now been separated and submucous fibrosis and HPV-associated dysplasia are also discussed in separate sections. Carcinoma cuniculatum and verrucous carcinoma are described in dedicated sections, reflecting that the oral cavity is the most common location in the head and neck for both these entities which have distinct clinical and histologic features from conventional squamous cell carcinoma. This review summarizes the changes in Chapter 5 with special reference to new additions, deletions, and sections that reflect current clinical, histological, and molecular advances.

WHO Classification of Tumours Editorial Board. Head and neck tumours (WHO classification of tumours series, 5th ed. vol. 9). Lyon (France): International Agency for Research on Cancer 2022.

Carlson DL. Necrotizing sialometaplasia: a practical approach to the diagnosis. Arch Pathol Lab Med. 2009;133(5):692–8.PubMedCrossRef

Abrams AM, Melrose RJ, Howell FV. Necrotizing sialometaplasia. A disease simulating malignancy. Cancer. 1973;32(1):130–5.PubMedCrossRef

Fowler CB, Brannon RB. Subacute necrotizing sialadenitis: report of 7 cases and a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89(5):600–9.PubMedCrossRef

Kaplan I, et al. The clinical, histologic, and treatment spectrum in necrotizing sialometaplasia. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114(5):577–85.PubMedCrossRef

Sethi S, et al. An update on Heck's disease-a systematic review. J Public Health (Oxf) 2021.

Fornatora ML, et al. Oral melanoacanthoma: a report of 10 cases, review of the literature, and immunohistochemical analysis for HMB-45 reactivity. Am J Dermatopathol. 2003;25(1):12–5.PubMedCrossRef

Albuquerque DM, et al. Oral pigmented lesions: a retrospective analysis from Brazil. Med Oral Patol Oral Cir Bucal. 2021;26(3):e284–91.PubMedCrossRef

Cantudo-Sanagustín E, et al. Pathogenesis and clinicohistopathological caractheristics of melanoacanthoma: a systematic review. J Clin Exp Dent. 2016;8(3):e327–36.PubMedPubMedCentral

10.

Fitzpatrick SG, Hirsch SA, Gordon SC. The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review. J Am Dent Assoc. 2014;145(1):45–56.PubMedCrossRef

11.

Ramos-García P, González-Moles MÁ, Warnakulasuriya S. Oral cancer development in lichen planus and related conditions-3.0 evidence level: a systematic review of systematic reviews. Oral Dis. 2021;27(8):1919–1935.

12.

Muller S. Oral lichenoid lesions: distinguishing the benign from the deadly. Mod Pathol. 2017;30(s1):S54-s67.PubMedCrossRef

13.

Aguirre-Urizar JM, Lafuente-Ibáñez de Mendoza I, Warnakulasuriya S. Malignant transformation of oral leukoplakia: systematic review and meta-analysis of the last 5 years. Oral Dis 2021;27(8):1881–1895.

14.

Warnakulasuriya S, et al. Oral potentially malignant disorders: a consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer. Oral Dis. 2021;27(8):1862–80.PubMedCrossRef

15.

Odell E, et al. Oral epithelial dysplasia: recognition, grading and clinical significance. Oral Dis. 2021;27(8):1947–76.PubMedCrossRef

16.

Barnes L, Eveson JW, Reichart P, Sidransky D. Pathology and genetics of head and neck tumours. In: Kleihues P, Sobin LH, editors. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005.

17.

Woo SB. Oral epithelial dysplasia and premalignancy. Head Neck Pathol. 2019;13(3):423–39.PubMedPubMedCentralCrossRef

18.

Muller S. Oral epithelial dysplasia, atypical verrucous lesions and oral potentially malignant disorders: focus on histopathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125(6):591–602.PubMedCrossRef

19.

Warnakulasuriya S, et al. Oral epithelial dysplasia classification systems: predictive value, utility, weaknesses and scope for improvement. J Oral Pathol Med. 2008;37(3):127–33.PubMedCrossRef

20.

Nankivell P, et al. The binary oral dysplasia grading system: validity testing and suggested improvement. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115(1):87–94.PubMedCrossRef

21.

Thompson LDR, et al. Proliferative verrucous leukoplakia: an expert consensus guideline for standardized assessment and reporting. Head Neck Pathol. 2021;15(2):572–87.PubMedPubMedCentralCrossRef

22.

Mello FW, et al. Prevalence of oral potentially malignant disorders: a systematic review and meta-analysis. J Oral Pathol Med. 2018;47(7):633–40.PubMedCrossRef

23.

Betel-quid and areca-nut chewing and some areca-nut derived nitrosamines. IARC Monogr Eval Carcinog Risks Hum 2004;85:1–334.

24.

Rao NR, et al. Oral submucous fibrosis: a contemporary narrative review with a proposed inter-professional approach for an early diagnosis and clinical management. J Otolaryngol Head Neck Surg. 2020;49(1):3.PubMedPubMedCentralCrossRef

25.

Bhatt P, et al. Assessment and correlation between functional and histological staging of oral submucous fibrosis: a clinicohistopathologic study. Natl J Maxillofac Surg. 2019;10(1):27–32.PubMedPubMedCentralCrossRef

26.

Peng Q, et al. Oral submucous fibrosis in Asian countries. J Oral Pathol Med. 2020;49(4):294–304.PubMedCrossRef

27.

Shen YW, et al. Oral submucous fibrosis: a review on biomarkers, pathogenic mechanisms, and treatments. Int J Mol Sci 2020;21(19).

28.

Tilakaratne WM, et al. Oral submucous fibrosis: review on aetiology and pathogenesis. Oral Oncol. 2006;42(6):561–8.PubMedCrossRef

29.

Utsunomiya H, et al. Extracellular matrix remodeling in oral submucous fibrosis: its stage-specific modes revealed by immunohistochemistry and in situ hybridization. J Oral Pathol Med. 2005;34(8):498–507.PubMedCrossRef

30.

Ekanayaka RP, Tilakaratne WM. Oral submucous fibrosis: review on mechanisms of malignant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122(2):192–9.PubMedCrossRef

31.

Kujan O, Mello FW, Warnakulasuriya S. Malignant transformation of oral submucous fibrosis: a systematic review and meta-analysis. Oral Dis. 2021;27(8):1936–46.PubMedCrossRef

32.

Lerman MA, et al. HPV-16 in a distinct subset of oral epithelial dysplasia. Mod Pathol. 2017;30(12):1646–54.PubMedCrossRef

33.

McCord C, et al. Association of high-risk human papillomavirus infection with oral epithelial dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115(4):541–9.PubMedCrossRef

34.

Hendawi N, et al. Human papillomavirus (HPV) can establish productive infection in dysplastic oral mucosa, but HPV status is poorly predicted by histological features and p16 expression. Histopathology. 2020;76(4):592–602.PubMedCrossRef

35.

Alsabbagh A, et al. Surrogate markers for high-risk human papillomavirus infection in oral epithelial dysplasia: a comparison of p16, Ki-67, and ProExC. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020;129(3):246-259.e1.PubMedCrossRef

36.

de la Cour CD, et al. Prevalence of human papillomavirus in oral epithelial dysplasia: systematic review and meta-analysis. Head Neck. 2020;42(10):2975–84.PubMedCrossRef

37.

Khanal S, et al. Histologic variation in high grade oral epithelial dysplasia when associated with high-risk human papillomavirus. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123(5):566–85.PubMedCrossRef

38.

Sung H, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.PubMedCrossRef

39.

Kuruvilla J, Nayar KR. Distribution pattern and its correlation for oral cancer rate and human development rank for countries: an ecological approach. Contemp Clin Dent. 2021;12(1):9–13.PubMedPubMedCentralCrossRef

40.

Ng JH, et al. Changing epidemiology of oral squamous cell carcinoma of the tongue: a global study. Head Neck. 2017;39(2):297–304.PubMedCrossRef

41.

Asthana S, et al. Association of smokeless tobacco use and oral cancer: a systematic global review and meta-analysis. Nicotine Tob Res. 2019;21(9):1162–71.PubMedCrossRef

42.

Gupta B, Johnson NW. Systematic review and meta-analysis of association of smokeless tobacco and of betel quid without tobacco with incidence of oral cancer in South Asia and the Pacific. PLoS ONE. 2014;9(11):e113385.PubMedPubMedCentralCrossRef

43.

Zafereo ME, et al. Squamous cell carcinoma of the oral cavity often overexpresses p16 but is rarely driven by human papillomavirus. Oral Oncol. 2016;56:47–53.PubMedPubMedCentralCrossRef

44.

de Freitas Silva BS, et al. Binary and WHO dysplasia grading systems for the prediction of malignant transformation of oral leukoplakia and erythroplakia: a systematic review and meta-analysis. Clin Oral Investig. 2021;25(7):4329–40.PubMedCrossRef

45.

Subramaniam N, et al. Adverse pathologic features in early oral squamous cell carcinoma and the role of postoperative radiotherapy-a review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124(1):24–31.PubMedCrossRef

46.

Almangush A, et al. Clinical significance of tumor-stroma ratio in head and neck cancer: a systematic review and meta-analysis. BMC Cancer. 2021;21(1):480.PubMedPubMedCentralCrossRef

47.

Xu B, et al. The prognostic role of histologic grade, worst pattern of invasion, and tumor budding in early oral tongue squamous cell carcinoma: a comparative study. Virchows Arch. 2021;479(3):597–606.PubMedCrossRef

48.

Almangush A, et al. Staging and grading of oral squamous cell carcinoma: an update. Oral Oncol. 2020;107:104799.PubMedCrossRef

49.

Caldeira PC, et al. Tumor depth of invasion and prognosis of early-stage oral squamous cell carcinoma: a meta-analysis. Oral Dis. 2020;26(7):1357–65.PubMedCrossRef

50.

Almangush A, et al. Tumour budding in oral squamous cell carcinoma: a meta-analysis. Br J Cancer. 2018;118(4):577–86.PubMedCrossRef

51.

Alonso JE, et al. A population-based analysis of verrucous carcinoma of the oral cavity. Laryngoscope. 2018;128(2):393–7.PubMedCrossRef

52.

Koch BB, et al. National survey of head and neck verrucous carcinoma: patterns of presentation, care, and outcome. Cancer. 2001;92(1):110–20.PubMedCrossRef

53.

Patel KR, et al. Verrucous carcinoma with dysplasia or minimal invasion: a variant of verrucous carcinoma with extremely favorable prognosis. Head Neck Pathol. 2015;9(1):65–73.PubMedCrossRef

54.

Farag AF, Abou-Alnour DA, Abu-Taleb NS. Oral carcinoma cuniculatum, an unacquainted variant of oral squamous cell carcinoma: a systematic review. Imaging Sci Dent. 2018;48(4):233–44.PubMedPubMedCentralCrossRef

55.

Datar UV, Kale A, Mane D. Oral carcinoma cuniculatum: a new entity in the clinicopathological spectrum of oral squamous cell carcinoma. J Clin Diagn Res 2017;11(1):ZD37-ZD39.

56.

Padilla RJ, Murrah VA. Carcinoma cuniculatum of the oral mucosa: a potentially underdiagnosed entity in the absence of clinical correlation. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118(6):684–93.PubMedCrossRef

57.

Fonseca FP, et al. Oral carcinoma cuniculatum: two cases illustrative of a diagnostic challenge. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(4):457–63.PubMedCrossRef

58.

Zhang C, et al. Oral carcinoma cuniculatum presenting with moth-eaten destruction of the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125(4):e86–93.PubMedCrossRef

59.

Schrader KA, et al. Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11. Clin Genet. 2009;75(2):185–9.PubMedCrossRef

60.

Ramaswamy PV, et al. Multiple granular cell tumors in a child with Noonan syndrome. Pediatr Dermatol. 2010;27(2):209–11.PubMedCrossRef

61.

França JA, et al. Sporadic granular cell tumours lack recurrent mutations in PTPN11, PTEN and other cancer-related genes. J Clin Pathol. 2018;71(1):93–4.PubMedCrossRef

62.

Liu Y, et al. Granular cell tumors overexpress TFE3 without gene rearrangement: evaluation of immunohistochemistry and break-apart FISH in 45 cases. Oncol Lett. 2019;18(6):6355–60.PubMedPubMedCentral

63.

Pareja F, et al. Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors. Nat Commun. 2018;9(1):3533.PubMedPubMedCentralCrossRef

64.

Kato MG, et al. Clinical features of ectomesenchymal chondromyxoid tumors: a systematic review of the literature. Oral Oncol. 2017;67:192–7.PubMedCrossRef

65.

Truschnegg A, et al. Ectomesenchymal chondromyxoid tumor: a comprehensive updated review of the literature and case report. Int J Oral Sci. 2018;10(1):4.PubMedPubMedCentralCrossRef

66.

Dickson BC, et al. Ectomesenchymal chondromyxoid tumor: a neoplasm characterized by recurrent RREB1-MKL2 fusions. Am J Surg Pathol. 2018;42(10):1297–305.PubMedPubMedCentralCrossRef

67.

Makise N, et al. Mesenchymal tumors with RREB1-MRTFB fusion involving the mediastinum: extra-glossal ectomesenchymal chondromyxoid tumors? Histopathology 2020.

68.

Gomes CC, et al. BRAFV600E mutation in melanotic neuroectodermal tumor of infancy: toward personalized medicine? Pediatrics. 2015;136(1):e267–9.PubMedCrossRef

69.

Barnes DJ, et al. A germline mutation of CDKN2A and a novel RPLP1-C19MC fusion detected in a rare melanotic neuroectodermal tumor of infancy: a case report. BMC Cancer. 2016;16:629.PubMedPubMedCentralCrossRef

70.

Lopez-Nunez O, et al. Melanotic Neuroectodermal Tumor of Infancy (MNTI) and pineal anlage tumor (PAT) harbor a medulloblastoma signature by DNA methylation profiling. Cancers (Basel) 2021;13(4).

71.

Chrcanovic BR, Gomez RS. Melanotic neuroectodermal tumour of infancy of the jaws: an analysis of diagnostic features and treatment. Int J Oral Maxillofac Surg. 2019;48(1):1–8.PubMedCrossRef

Titel: Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Tumours of the Oral Cavity and Mobile Tongue
verfasst von: Susan Muller
Wanninayake M. Tilakaratne
Publikationsdatum: 21.03.2022
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 1/2022
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-021-01402-9

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