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2018 | OriginalPaper | Buchkapitel

8. Urinmarker beim Blasenkarzinom

verfasst von : Prof. Dr. med. Oliver W. Hakenberg

Erschienen in: Urinzytologie und Sedimentanalyse

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Der wesentliche urin-basierte «Urinmarker« bleibt die Beurteilung der zellulären Urinbestandteile mithilfe der Urinzytologie. Die Suche nach zuverlässigen anderen Urinmarkern hat zu vermarkteten Produkten geführt, die zwar oft eine höhere Sensitivität gerade im Bereich der ‚Low-grade‘ Tumoren erreichen als die Urinzytologie, aber auch eine höhere falsch-positive Rate sowie vor allem eine deutlich niedrigere Spezifität, und damit eine geringere Zuverlässigkeit im Ausschluss eines ‚High-grade‘ Tumors. Dennoch bleibt die Suche nach Urinmarkern für das Urothelkarzinom ein bedeutsames Forschungsgebiet, was vor allem für die Nachsorge des nicht-muskelinvasiven Blasenkarzinoms enorme Bedeutung hätte. Verfeinerte zellbasierte Verfahren wie die Immunzytologie sind hierbei erfolgversprechend. Die enorme Ausweitung der Nachweismöglichkeiten auf molekulargenetische Veränderungen, Peptide und Proteine, Nukleinsäuren und anderes mehr im Urin mithilfe von ‚high throughput‘-Verfahren aus den Bereichen ‚Genomics, Proteomics und Metabolomics‘ hat die Palette an potenziellen Markern enorm erweitert.
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Zurück zum Zitat Vlahou A, Schellhammer PF, et al. (2001). «Development of a novel proteomic approach for the detection of transitional cell carcinoma of the bladder in urine.» Am J Pathol 158(4): 1491-1502. Vlahou A, Schellhammer PF, et al. (2001). «Development of a novel proteomic approach for the detection of transitional cell carcinoma of the bladder in urine.» Am J Pathol 158(4): 1491-1502.
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Zurück zum Zitat Wang XS, Zhang Z, et al. (2006). «Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma.» Clin Cancer Res 12(16): 4851-8. Wang XS, Zhang Z, et al. (2006). «Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma.» Clin Cancer Res 12(16): 4851-8.
Zurück zum Zitat Weikert S, Christoph F, et al. (2005). «Quantitative analysis of survivin mRNA expression in urine and tumor tissue of bladder cancer patients and its potential relevance for disease detection and prognosis.» Int J Cancer 116(1): 100-104. Weikert S, Christoph F, et al. (2005). «Quantitative analysis of survivin mRNA expression in urine and tumor tissue of bladder cancer patients and its potential relevance for disease detection and prognosis.» Int J Cancer 116(1): 100-104.
Zurück zum Zitat Willis CM, Church SM, et al. (2004). «Olfactory detection of human bladder cancer by dogs: proof of principle study.» Brit Med J 329: 712-718. Willis CM, Church SM, et al. (2004). «Olfactory detection of human bladder cancer by dogs: proof of principle study.» Brit Med J 329: 712-718.
Zurück zum Zitat Wittmann BM, Stirdivant SM, et al. (2014). «Bladder cancer biomarker discovery using global metabolomic profiling of urine.» PLoS One 9(12): e115870. Wittmann BM, Stirdivant SM, et al. (2014). «Bladder cancer biomarker discovery using global metabolomic profiling of urine.» PLoS One 9(12): e115870.
Zurück zum Zitat Yamada Y, Enokida H, et al. (2011). «MiR-96 and miR-183 detection in urine serve as potential tumor markers of urothelial carcinoma: correlation with stage and grade, and comparison with urinary cytology.» Cancer Sci 102(3): 522-9. Yamada Y, Enokida H, et al. (2011). «MiR-96 and miR-183 detection in urine serve as potential tumor markers of urothelial carcinoma: correlation with stage and grade, and comparison with urinary cytology.» Cancer Sci 102(3): 522-9.
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Zurück zum Zitat Yao WJ, Chang CJ, et al. (1995). «Significance of urinary tissue polypeptide specific antigen (TPS) determination in patients with urothelial carcinoma.» Anticancer Res 15: 2819-2823. Yao WJ, Chang CJ, et al. (1995). «Significance of urinary tissue polypeptide specific antigen (TPS) determination in patients with urothelial carcinoma.» Anticancer Res 15: 2819-2823.
Zurück zum Zitat Zaak D, Karl A, et al. (2005). «Diagnosis of urothelial carcinoma of the bladder using fluorescence endoscopy.» BJU Int 96(2): 217-222. Zaak D, Karl A, et al. (2005). «Diagnosis of urothelial carcinoma of the bladder using fluorescence endoscopy.» BJU Int 96(2): 217-222.
Zurück zum Zitat Zhang YF, Wu DL, et al. (2004). «Tree analysis of mass spectral urine profiles discriminates transitional cell carcinoma of the bladder from noncancer patient.» Clin Biochem 37(9): 772-779. Zhang YF, Wu DL, et al. (2004). «Tree analysis of mass spectral urine profiles discriminates transitional cell carcinoma of the bladder from noncancer patient.» Clin Biochem 37(9): 772-779.
Zurück zum Zitat Zhou Y, Song R, et al. (2017). «Discovery and validation of potential urinary biomarkers for bladder cancer diagnosis using a pseudotargeted GC-MS metabolomics method.» Oncotarget. Zhou Y, Song R, et al. (2017). «Discovery and validation of potential urinary biomarkers for bladder cancer diagnosis using a pseudotargeted GC-MS metabolomics method.» Oncotarget.
Zurück zum Zitat Zuiverloon TC, van der Aa MN, et al. (2010). «Fibroblast growth factor receptor 3 mutation analysis on voided urine for surveillance of patients with low-grade non-muscle-invasive bladder cancer.» Clin Cancer Res 16(11): 3011-8. Zuiverloon TC, van der Aa MN, et al. (2010). «Fibroblast growth factor receptor 3 mutation analysis on voided urine for surveillance of patients with low-grade non-muscle-invasive bladder cancer.» Clin Cancer Res 16(11): 3011-8.
Metadaten
Titel
Urinmarker beim Blasenkarzinom
verfasst von
Prof. Dr. med. Oliver W. Hakenberg
Copyright-Jahr
2018
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-55660-3_8

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