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Erschienen in:
03.06.2022 | Gastrointestinal
Value of 3-T MR imaging in intraductal papillary mucinous neoplasm with a concomitant invasive carcinoma
Erschienen in: European Radiology | Ausgabe 12/2022
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Objectives
To examine the value of 3-T MRI for evaluating the difference between the pancreatic parenchyma of intraductal papillary mucinous neoplasm with a concomitant invasive carcinoma (IPMN-IC) and the pancreatic parenchyma of patients without an IPMN-IC.
Methods
A total of 132 patients underwent abdominal 3-T MRI. Of the normal pancreatic parenchymal measurements, the pancreas-to-muscle signal intensity ratio in in-phase imaging (SIR-I), SIR in opposed-phase imaging (SIR-O), SIR in T2-weighted imaging (SIR-T2), ADC (×10−3 mm2/s) in DWI, and proton density fat fraction (PDFF [%]) in multi-echo 3D DIXON were calculated. The patients were divided into three groups (normal pancreas group: n = 60, intraductal papillary mucinous neoplasm (IPMN) group: n = 60, IPMN-IC group: n = 12).
Results
No significant differences were observed among the three groups in age, sex, body mass index, prevalence of diabetes mellitus, and hemoglobin A1c (p = 0.141 to p = 0.657). In comparisons among the three groups, the PDFF showed a significant difference (p < 0.001), and there were no significant differences among the three groups in SIR-I, SIR-O, SIR-T2, and ADC (p = 0.153 to p = 0.684). The PDFF of the pancreas was significantly higher in the IPMN-IC group than in the normal pancreas group or the IPMN group (p < 0.001 and p < 0.001, respectively), with no significant difference between the normal pancreas group and the IPMN group (p = 0.916).
Conclusions
These observations suggest that the PDFF of the pancreas is associated with the presence of IPMN-IC.
Key Points
• The cause and risk factors of IPMN with a concomitant invasive carcinoma have not yet been clarified.
• The PDFF of the pancreas was significantly higher in the IPMN-IC group than in the normal pancreas group or the IPMN group.
• Pancreatic PDFF may be a potential biomarker for the development of IPMN with a concomitant invasive carcinoma.