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Erschienen in: Clinical Autonomic Research 2/2022

24.02.2022 | EDITORIAL

What new can we learn from cardiac sympathetic neuroimaging in synucleinopathies?

verfasst von: Guillaume Lamotte, David S. Goldstein

Erschienen in: Clinical Autonomic Research | Ausgabe 2/2022

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Excerpt

Neuroimaging evidence indicating cardiac sympathetic denervation in the Lewy body (LB) synucleinopathy Parkinson disease (PD) and generally intact innervation in the non-LB synucleinopathy multiple system atrophy (MSA) was first reported using 18F-dopamine ( 18F-DA) positron emission tomography (PET) imaging [ 1]. Numerous studies since then, mainly using 123I-metaiodobenzylguanidine ( 123I-MIBG) single-photon emission computed tomographic (SPECT) scanning, have confirmed these findings. Of 21 studies in English on this topic involving at least 50 patients, all 21 have reported a significant group difference in the direction of cardiac noradrenergic deficiency in PD (Table 1).
Table 1
Studies using cardiac sympathetic neuroimaging in patients with Parkinson disease (PD) and multiple system atrophy (MSA)
PMID
First author
Year
Country
PD N
MSA N
TotalN
PD ≠ MSA a
9366173
Yoshita
1997
Japan
25
25
50
Yes
10406987
Orimo
1999
Japan
46
7
53
Yes
10979878
Goldstein
2000
USA
29
24
53
Yes
10853813
Taki
2000
Japan
41
9
50
Yes
10872011
Takatsu
2000
Japan
40
12
52
Yes
15654042
Nagayama
2005
Japan
122
14
136
Yes
20396485
Shin
2006
Korea
40
23
63
Yes
16818943
Kashihara
2006
Japan
130
11
141
Yes
19418293
Escamilla-Sevilla
2009
Spain
51
9
60
Yes
20127386
Yamashita
2010
Japan
38
20
58
Yes
21840242
Kikuchi
2011
Japan
42
42
84
Yes b
22082889
Kurata
2011
Japan
113
16
139
Yes
21342781
Tateno
2011
Japan
90
14
104
Yes
23613784
Umemura
2013
Japan
118
20
138
Yes
26303385
Mochizuki
2015
Japan
191
42
233
Yes
27812167
Fujita
2016
Japan
101
21
122
Yes
30324423
Gabilondo
2018
Spain
85
40
125
Yes
31715596
Ikeda
2019
Japan
77
35
112
Yes
34316615
Sakuramoto
2019
Japan
70
16
86
Yes
33392714
Iwabuchi
2021
Japan
90
9
99
Yes
33981791
Lenka
2021
USA
50
68
118
Yes
aStatistically significant difference between PD and MSA
bStatistically significant difference between PD and MSA as a group. No difference between PD and MSA-P ( N = 19). Statistically significant difference between PD and MSA-C ( N = 23)
Literatur
1.
Zurück zum Zitat Goldstein DS, Holmes C, Cannon RO 3rd, Eisenhofer G, Kopin IJ (1997) Sympathetic cardioneuropathy in dysautonomias. N Engl J Med 336(10):696–702 CrossRefPubMed Goldstein DS, Holmes C, Cannon RO 3rd, Eisenhofer G, Kopin IJ (1997) Sympathetic cardioneuropathy in dysautonomias. N Engl J Med 336(10):696–702 CrossRefPubMed
2.
Zurück zum Zitat Eckhardt C, Krismer F, Donnemiller E, Eschlböck S, Fanciulli A, Raccagni C, Bösch S, Mair K, Scherfler C, Djamshidian A, Uprimny C, Metzler B, Seppi K, Poewe W, Kiechl S, Virgolini I, Wenning GK (2022) Cardiac sympathetic innervation in Parkinson’s disease versus multiple system atrophy. Clin Auton Res. Accessed 19 Feb 2022 ( ahead of print) Eckhardt C, Krismer F, Donnemiller E, Eschlböck S, Fanciulli A, Raccagni C, Bösch S, Mair K, Scherfler C, Djamshidian A, Uprimny C, Metzler B, Seppi K, Poewe W, Kiechl S, Virgolini I, Wenning GK (2022) Cardiac sympathetic innervation in Parkinson’s disease versus multiple system atrophy. Clin Auton Res. Accessed 19 Feb 2022 ( ahead of print)
3.
Zurück zum Zitat Goldstein DS, Holmes CS, Dendi R, Bruce SR, Li ST (2002) Orthostatic hypotension from sympathetic denervation in Parkinson’s disease. Neurology 58(8):1247–1255 CrossRefPubMed Goldstein DS, Holmes CS, Dendi R, Bruce SR, Li ST (2002) Orthostatic hypotension from sympathetic denervation in Parkinson’s disease. Neurology 58(8):1247–1255 CrossRefPubMed
13.
Zurück zum Zitat Horsager J, Andersen KB, Knudsen K, Skjaerbaek C, Fedorova TD, Okkels N, Schaeffer E, Bonkat SK, Geday J, Otto M, Sommerauer M, Danielsen EH, Bech E, Kraft J, Munk OL, Hansen SD, Pavese N, Goder R, Brooks DJ, Berg D, Borghammer P (2020) Brain-first versus body-first Parkinson’s disease: a multimodal imaging case-control study. Brain 143(10):3077–3088. https://​doi.​org/​10.​1093/​brain/​awaa238 CrossRefPubMed Horsager J, Andersen KB, Knudsen K, Skjaerbaek C, Fedorova TD, Okkels N, Schaeffer E, Bonkat SK, Geday J, Otto M, Sommerauer M, Danielsen EH, Bech E, Kraft J, Munk OL, Hansen SD, Pavese N, Goder R, Brooks DJ, Berg D, Borghammer P (2020) Brain-first versus body-first Parkinson’s disease: a multimodal imaging case-control study. Brain 143(10):3077–3088. https://​doi.​org/​10.​1093/​brain/​awaa238 CrossRefPubMed
16.
Zurück zum Zitat Doppler CEJ, Kinnerup MB, Brune C, Farrher E, Betts M, Fedorova TD, Schaldemose JL, Knudsen K, Ismail R, Seger AD, Hansen AK, Staer K, Fink GR, Brooks DJ, Nahimi A, Borghammer P, Sommerauer M (2021) Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson’s disease. Brain 144(9):2732–2744. https://​doi.​org/​10.​1093/​brain/​awab236 CrossRefPubMed Doppler CEJ, Kinnerup MB, Brune C, Farrher E, Betts M, Fedorova TD, Schaldemose JL, Knudsen K, Ismail R, Seger AD, Hansen AK, Staer K, Fink GR, Brooks DJ, Nahimi A, Borghammer P, Sommerauer M (2021) Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson’s disease. Brain 144(9):2732–2744. https://​doi.​org/​10.​1093/​brain/​awab236 CrossRefPubMed
Metadaten
Titel
What new can we learn from cardiac sympathetic neuroimaging in synucleinopathies?
verfasst von
Guillaume Lamotte
David S. Goldstein
Publikationsdatum
24.02.2022
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Autonomic Research / Ausgabe 2/2022
Print ISSN: 0959-9851
Elektronische ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-022-00859-0

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