Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende Patientenratgeber
Erweiterte Suche
Anmelden
nach oben
Forensic Science, Medicine and Pathology
Erschienen in:

15.01.2024 | Case Report

Death due to sickle cell crisis: a case report

verfasst von: Teaghan Koster, Elizabeth Boyer, David J. Clutterbuck, Hadas Benhabib, Jayantha Herath

Erschienen in: Forensic Science, Medicine and Pathology | Ausgabe 3/2024

Einloggen, um Zugang zu erhalten

Abstract

Sickle cell disease (SCD) is the most common hereditary hemoglobinopathy worldwide. It results in characteristic acute and chronic findings on postmortem computed tomography (PMCT), macroscopic and microscopic examinations. While the diagnostic imaging and macroscopic features are not specific for SCD on their own, when coupled with microscopic features such as sickled erythrocytes and evidence of chronic venous congestion (i.e., Gamna-Gandy bodies), these clues can help alert forensic pathologists to the presence of SCD. Despite the prevalence of the disease and the constellation of findings alluded to above, SCD is not often explored in forensic pathology literature. This case demonstrates classic acute and chronic features of SCD on PMCT, macroscopic and microscopic examinations. It explores the pathophysiology leading to sudden and unexpected death in a person with SCD and possible pitfalls in attribution of cause of death.
Literatur
1.
Mortal GBD. Causes Death Collab. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;385:117–71.
2.
Sundd P, Gladwin MT, Novelli EM. Pathophysiology of sickle cell disease. Annu Rev Pathol. 2019;14:263–92.CrossRefPubMed
3.
4.
5.
Kumar V, Abbas A, Aster J, et al. Red blood cell and bleeding disorders. In: Robbins and Cotran Pathologic Basis of Disease. 10th ed., Elsevier; 2021:641–44.
6.
Osborn M, Lowe J, Lucas S, et al. Guidelines on autopsy practice: autopsy in sickle cell disease and persons with sickle cell trait. R Coll Pathol. 2017.
7.
Sheshanna N, Sethi G, Prakash SM. Sudden death in sickle cell disease: an autopsy diagnosis. J M Sci. 2017;3:113–5.
8.
Noubiap JJ, Temgoua MN, Tankeu R, et al. Sickle cell disease, sickle trait and the risk for venous thromboembolism: a systematic review and meta-analysis. Thromb J. 2018;16:27.CrossRefPubMedPubMedCentral
9.
10.
Piccin A, Rizkalla H, Smith O, et al. Composition and significance of splenic Gamna-Gandy bodies in sickle cell anemia. Hum Pathol. 2012;43:1028–36.CrossRefPubMed
11.
Basso C, Michaud K, d’Amati G, et al. Association for European cardiovascular pathology. Cardiac hypertrophy at autopsy Virchows Arch. 2021;479:79–94.PubMed
12.
Whipple NS, Joshi VM, Naik RJ, et al. Sickle cell disease and ventricular myocardial strain: a systematic review. Pediatr Blood Cancer. 2021;68:e28973.CrossRefPubMedPubMedCentral
13.
Barbosa MM, Vasconcelos MC, Ferrari TC, et al. Assessment of ventricular function in adults with sickle cell disease: role of two-dimensional speckle-tracking strain. J Am Soc Echocardiogr. 2014;27:1216–22.CrossRefPubMed
14.
Darbari DS, Kple-Faget P, Kwagyan J, et al. Circumstances of death in adult sickle cell disease patients. Am J Hematol. 2006;81:858–63.CrossRefPubMed
15.
Manci EA, Culberson DE, Yang YM, et al. Causes of death in sickle cell disease: an autopsy study. Br J Haematol. 2003;123:359–65.CrossRefPubMed
16.
Ogun GO, Ebili H, Kotila TR. Autopsy findings and pattern of mortality in Nigerian sickle cell disease patients. Pan Afr Med J. 2014;18.
17.
18.
He R, Oliveira JL, Hoyer JD, Viswanatha DS, Molecular hematopathology. In: Hsi ED, editor. Foundations in Diagnostic Pathology, Hematopathology 3rd ed. 2018. pp. 712–760.
19.
Rashid SA, Krauskopf A, Vonlanthen B, et al. Sudden death in a case of sickle cell anemia: post-mortem computed tomography and autopsy correlation from a radiologist’s perspective. Leg Med. 2013;15:213–6.CrossRef
20.
Dyson SM, Boswell G. Sickle cell anaemia and deaths in custody in the UK and the USA. Howard J Crime Justice. 2006;45:14–28.CrossRef
21.
22.
23.
Metadaten
Titel
Death due to sickle cell crisis: a case report
verfasst von
Teaghan Koster
Elizabeth Boyer
David J. Clutterbuck
Hadas Benhabib
Jayantha Herath
Publikationsdatum
15.01.2024
Verlag
Springer US
Erschienen in
Forensic Science, Medicine and Pathology / Ausgabe 3/2024
Print ISSN: 1547-769X
Elektronische ISSN: 1556-2891
DOI
https://doi.org/10.1007/s12024-023-00774-4

Weitere Artikel der Ausgabe 3/2024

On the forensic relevance of tattoos: distinguishing black inks with energy dispersive spectroscopy and backscattered scanning electron microscopy

  • Technical Report

Placenta percreta in primigravida with unscarred uterus complicated by uterine rupture and sudden maternal and fetal death: an autopsy case report

  • Case Report

Commentary on De-Giorgio F, Bergamin E, Baldi A, Gatta R, Pascali VL. Immunohistochemical expression of HMGB1 and related proteins in the skin as a possible tool for determining post-mortem interval: a preclinical study

  • Letter to the Editor

More on: ‘the role of restraint in fatal excited delirium syndrome’

  • Open Access
  • Brief Communication

Postoperative rhabdomyolysis following otoplasty: an autopsy case report

  • Case Report

Fluctuating asymmetry in third molar agenesis as an aid to estimate socioeconomic status

  • Open Access
  • Original Article

Neu im Fachgebiet Pathologie

Overview of a comparative analysis of microsatellite instability and standard mismatch repair protein-deficiency tests in a large cancer cohort

  • Hauptreferate: Hauptprogramm der DGP

A retrospective analysis was carried out based on a large cancer patient cohort of our institute ( n  = 1306; collected from 2018 to 2023). dMMR was tested by four IHC reactions (MLH1 and PMS2 or MSH2 and MSH 6). Further, parallel pentaplex …

Molekulare Testung bei mesenchymalen Neoplasien: Was, wann und wie testen?

Mit dem weit verbreiteten Einsatz diverser molekularer Methoden in der histopathologischen Routinediagnostik hat die Tumorklassifikation in den letzten beiden Jahrzehnten signifikante Fortschritte gemacht. Dabei wurden zum einen zahlreiche …

Reconstructing 3D histological structures using machine learning (artificial intelligence) algorithms

  • Hauptreferate: Hauptprogramm der DGP

Artificial intelligence (AI) has recently been applied to pathological and medical image analysis with high sensitivity and specificity [ 1 , 2 ], aiding in various dental diagnostic techniques. The use of AI in image annotation has enhanced the …

Key considerations when implementing new diagnostic technologies in routine practice

  • Hauptreferate: Arbeitsgemeinschaften der DGP

This review explores several key considerations that are critical for implementing new diagnostic technologies into routine practice. These elements will provide a comprehensive guide for navigating the complexities of integrating cutting-edge …