nach oben

Erschienen in:

01.10.2018 | Nephrology - Original Paper

Decreased percentage of memory B cells is independently associated with increased susceptibility to infection in patients on maintenance hemodialysis

verfasst von: Man Guo, Rongyi Chen, Fangfang Xiang, Xuesen Cao, Jiachang Hu, Zhihui Lu, Shaomin Gong, Xiaohong Chen, Xiao Chen, Xiaoqiang Ding, Bo Shen, Jianzhou Zou

Erschienen in: International Urology and Nephrology | Ausgabe 11/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Infection is a common complication and cause of death in patients on maintenance hemodialysis (MHD). B lymphocytes, which are an important component of the immune system, play a significant role in defending against pathogen invasion. However, in patients on MHD, the connection between infection and B cell subsets remains largely unknown. Our study aims to clarify the potential role of the distribution of B cell subsets in the infection process in patients on MHD.

Methods

In this cross-sectional study, basic information was collected from 175 patients on MHD from July 2016 to July 2017 at Zhongshan Hospital, Fudan University. The distributions of the B cell subsets in patients with and without infection were analyzed using flow cytometry to determine the role of B lymphocyte subsets in the infection process in patients on MHD.

Results

Among the 175 patients, 45 suffered from infection. The respiratory tract was the most common infection site, accounting for 67.86% of all infections. After adjustment using multivariate logistic regression models, memory B cells [per 1% increase, odds ratio [95% confidence interval (CI)]: 0.949 (0.915, 0.984), P < 0.01], switched memory B cells [per 1% increase, odds ratio (95% CI): 0.939 (0.898, 0.982), P < 0.01], naïve B cells [per 1% increase, odds ratio (95% CI): 1.042 (1.009, 1.075), P < 0.05] and IgG titers [per 1 g/L increase, odds ratio (95% CI): 0.779 (0.630, 0.963), P < 0.05] were independent risk factors for infection in dialysis patients.

Conclusion

A decrease in memory B cells is independently associated with an increased risk of infection in patients on dialysis.

Nur mit Berechtigung zugänglich

Williams JD, Topley N, Craig KJ, Mackenzie RK, Pischetsrieder M, Lage C, Passlick-Deetjen J (2004) The Euro-Balance Trial: the effect of a new biocompatible peritoneal dialysis fluid (balance) on the peritoneal membrane. Kidney Int 66(1):408–418. https://doi.org/10.1111/j.1523-1755.2004.00747.x CrossRefPubMed

Dalrymple LS, Johansen KL, Chertow GM, Cheng S-C, Grimes B, Gold EB, Kaysen GA (2010) Infection-related hospitalizations in older patients with ESRD. Am J Kidney Dis 56(3):522–530. https://doi.org/10.1053/j.ajkd.2010.04.016 CrossRefPubMedPubMedCentral

Eleftheriadis T, Antoniadi G, Liakopoulos V, Kartsios C, Stefanidis I (2007) Disturbances of acquired immunity in hemodialysis patients. Semin Dial 20(5):440–451. https://doi.org/10.1111/j.1525-139X.2007.00283.x CrossRefPubMed

Kato S, Chmielewski M, Honda H, Pecoits-Filho R, Matsuo S, Yuzawa Y, Tranaeus A, Stenvinkel P, Lindholm B (2008) Aspects of immune dysfunction in end-stage renal disease. Clin J Am Soc Nephrol 3(5):1526–1533. https://doi.org/10.2215/cjn.00950208 CrossRefPubMedPubMedCentral

Weill JC, Weller S, Reynaud CA (2009) Human marginal zone B cells. Annu Rev Immunol 27:267–285. https://doi.org/10.1146/annurev.immunol.021908.132607 CrossRefPubMed

Siebert JN, L’Huillier AG, Grillet S, Delhumeau C, Siegrist CA, Posfay-Barbe KM (2013) Memory B cell compartment constitution and susceptibility to recurrent lower respiratory tract infections in young children. J Leukoc Biol 93(6):951–962. https://doi.org/10.1189/jlb.0312117 CrossRefPubMed

Kruetzmann S, Rosado MM, Weber H, Germing U, Tournilhac O, Peter HH, Berner R, Peters A, Boehm T, Plebani A, Quinti I, Carsetti R (2003) Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen. J Exp Med 197(7):939–945. https://doi.org/10.1084/jem.20022020 CrossRefPubMedPubMedCentral

Weller S, Braun MC, Tan BK, Rosenwald A, Cordier C, Conley ME, Plebani A, Kumararatne DS, Bonnet D, Tournilhac O, Tchernia G, Steiniger B, Staudt LM, Casanova JL, Reynaud CA, Weill JC (2004) Human blood IgM “memory” B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire. Blood 104(12):3647–3654. https://doi.org/10.1182/blood-2004-01-0346 CrossRefPubMed

Tian C, Luskin GK, Dischert KM, Higginbotham JN, Shepherd BE, Crowe JJ (2007) Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human naive and memory B cells. Mol Immunol 44(9):2173–2183. https://doi.org/10.1016/j.molimm.2006.11.020 CrossRefPubMed

10.

Pahl MV, Gollapudi S, Sepassi L, Gollapudi P, Elahimehr R, Vaziri ND (2010) Effect of end-stage renal disease on B-lymphocyte subpopulations, IL-7, BAFF and BAFF receptor expression. Nephrol Dial Transplant 25(1):205–212. https://doi.org/10.1093/ndt/gfp397 CrossRefPubMed

11.

Betjes MG (2013) Immune cell dysfunction and inflammation in end-stage renal disease. Nat Rev Nephrol 9(5):255–265. https://doi.org/10.1038/nrneph.2013.44 CrossRefPubMed

12.

Kim KW, Chung BH, Jeon EJ, Kim BM, Choi BS, Park CW, Kim YS, Cho SG, Cho ML, Yang CW (2012) B cell-associated immune profiles in patients with end-stage renal disease (ESRD). Exp Mol Med 44(8):465–472. https://doi.org/10.3858/emm.2012.44.8.053 CrossRefPubMedPubMedCentral

13.

Girndt M, Sester M, Sester U, Kaul H, Köhler H (2001) Molecular aspects of T- and B-cell function in uremia. Kidney Int 59:S206–S211. https://doi.org/10.1046/j.1523-1755.2001.59780206.x CrossRef

14.

Center of Disease Prevention and Control (2012) NHSN dialysis event protocol. Center of Disease Prevention and Control, Atlanta

15.

Ministry of Health of the People’s Republic of China (2001) Diagnostic standards of nosocomial infections. Ministry of Health of the People’s Republic of China, Beijing

16.

Bloembergen WE, Port FK (1996) Epidemiological perspective on infections in chronic dialysis patients. Adv Renal Replace Ther 3(3):201–207CrossRef

17.

Lok CE, Stanley KE, Hux JE, Richardson R, Tobe SW, Conly J (2003) Hemodialysis infection prevention with polysporin ointment. J Am Soc Nephrol 14(1):169–179CrossRefPubMed

18.

Mailloux LU, Bellucci AG, Wilkes BM, Napolitano B, Mossey RT, Lesser M, Bluestone PA (1991) Mortality in dialysis patients: analysis of the causes of death. Am J Kidney Dis 18(3):326–335CrossRefPubMed

19.

Tokars JI, Miller ER, Stein G (2002) New national surveillance system for hemodialysis-associated infections: initial results. Am J Infect Control 30(5):288–295. https://doi.org/10.1067/mic.2002.120904 CrossRefPubMed

20.

Chen R, Hu J, Xiang F, Tan X, Shen B, Liu Z, Lv W, Ding X, Cao X, Zou J (2017) Decreased percentage of peripheral naive T cells is independently associated with ischemic stroke in patients on hemodialysis. Int Urol Nephrol 49(11):2051–2060. https://doi.org/10.1007/s11255-017-1691-y CrossRefPubMed

21.

Leiva LE, Monjure H, Sorensen RU (2013) Recurrent respiratory infections, specific antibody deficiencies, and memory B cells. J Clin Immunol 33(Suppl 1):S57–S61. https://doi.org/10.1007/s10875-012-9814-9 CrossRefPubMed

22.

Lanio N, Sarmiento E, Gallego A, Calahorra L, Jaramillo M, Navarro J, Palomo J, Fernandez-Yanez J, Ruiz M, Fernandez-Cruz E, Carbone J (2013) Alterations of naive and memory B-cell subsets are associated with risk of rejection and infection in heart recipients. Transpl Int 26(8):800–812. https://doi.org/10.1111/tri.12131 CrossRefPubMed

23.

Titanji K (2006) Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection. Blood 108(5):1580–1587. https://doi.org/10.1182/blood-2005-11-013383 CrossRefPubMed

24.

Kelly DF, Pollard AJ, Moxon ER (2005) Immunological memory—the role of B cells in long-term protection against invasive bacterial pathogens. JAMA 294(23):3019–3023. https://doi.org/10.1001/jama.294.23.3019 CrossRefPubMed

25.

Maurer D, Fischer GF, Fae I, Majdic O, Stuhlmeier K, Von Jeney N, Holter W, Knapp W (1992) IgM and IgG but not cytokine secretion is restricted to the CD27+ B lymphocyte subset. J Immunol 148(12):3700–3705PubMed

26.

Agematsu K, Nagumo H, Yang FC, Nakazawa T, Fukushima K, Ito S, Sugita K, Mori T, Kobata T, Morimoto C, Komiyama A (1997) B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production. Eur J Immunol 27(8):2073–2079. https://doi.org/10.1002/eji.1830270835 CrossRefPubMed

27.

Tangye SG, Avery DT, Deenick EK, Hodgkin PD (2003) Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune responses. J Immunol 170(2):686–694CrossRefPubMed

28.

Kurosaki T, Kometani K, Ise W (2015) Memory B cells. Nat Rev Immunol 15(3):149–159. https://doi.org/10.1038/nri3802 CrossRefPubMed

29.

Gourley TS, Wherry EJ, Masopust D, Ahmed R (2004) Generation and maintenance of immunological memory. Semin Immunol 16(5):323–333. https://doi.org/10.1016/j.smim.2004.08.013 CrossRefPubMed

30.

Zinkernagel RM (2000) On immunological memory. Philos 355:369–371

31.

Hilgendorf I, Mueller-Hilke B, Kundt G, Holler E, Hoffmann P, Edinger M, Freund M, Wolff D (2012) The lack of memory B cells including T cell independent IgM+ IgD+ memory B cells in chronic graft-versus host disease is associated with susceptibility to infection. Transpl Int 25 (1):87–96. https://doi.org/10.1111/j.1432-2277.2011.01388.x CrossRefPubMed

32.

D’Orsogna LJ, Krueger RG, McKinnon EJ, French MA (2007) Circulating memory B-cell subpopulations are affected differently by HIV infection and antiretroviral therapy. AIDS 21(13):1747–1752. https://doi.org/10.1097/QAD.0b013e32828642c7 CrossRefPubMed

33.

Robinson J (2004) Efficacy of pneumococcal immunization in patients with renal disease—what is the data? Am J Nephrol 24(4):402–409. https://doi.org/10.1159/000079883 CrossRefPubMed

34.

Eleftheriadis T, Tsiaga P, Antoniadi G, Liakopoulos V, Kortsaris A, Giannatos E, Barbutis K, Stefanidis I, Vargemezis V (2005) The value of serum antilipoarabinomannan antibody detection in the diagnosis of latent tuberculosis in hemodialysis patients. Am J Kidney Dis 46(4):706–712. https://doi.org/10.1053/j.ajkd.2005.06.021 CrossRefPubMed

Titel: Decreased percentage of memory B cells is independently associated with increased susceptibility to infection in patients on maintenance hemodialysis
verfasst von: Man Guo
Rongyi Chen
Fangfang Xiang
Xuesen Cao
Jiachang Hu
Zhihui Lu
Shaomin Gong
Xiaohong Chen
Xiao Chen
Xiaoqiang Ding
Bo Shen
Jianzhou Zou
Publikationsdatum: 01.10.2018
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 11/2018
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-018-1977-8

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

24.04.2024 | DGIM 2024 | Kongressbericht | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Decreased percentage of memory B cells is independently associated with increased susceptibility to infection in patients on maintenance hemodialysis

Abstract

Purpose

Methods

Results

Conclusion

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Update Innere Medizin

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 11/2018

The diagnostic value of human epididymis protein 4 as a novel biomarker in patients with renal dysfunction

Effect of maternal folic acid supplementation on prostatitis risk in the rat offspring

Efficacy and safety of low-intensity shock wave therapy in penile rehabilitation post nerve-sparing radical cystoprostatectomy: a randomized controlled trial

Initiation of the inflammatory response after renal ischemia/reperfusion injury during renal transplantation

Serum endocan and circadian heart rate variability in non-dialysis stage 5 chronic kidney disease patients

Correction to: Comparisons of percutaneous versus retroperitoneoscopic cryoablation for renal masses

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Update Innere Medizin