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01.12.2017 | Case report | Ausgabe 1/2017 Open Access

World Journal of Surgical Oncology 1/2017

Dedifferentiated endometrioid carcinoma of the uterus : report of four cases and review of literature

World Journal of Surgical Oncology > Ausgabe 1/2017
Jiheun Han, Eun Young Ki, Sung Eun Rha, SooYoung Hur, Ahwon Lee



Dedifferentiated endometrioid adenocarcinoma (DEAC) is rare and is known to be more aggressive than high-grade endometrioid carcinoma. Differentiating between the two is important to provide appropriate treatment for patients.

Case presentation

This is a retrospective study including four cases of DEAC of the uterus, which was diagnosed and treated in our Obstetrics and Gynecology department between January 2013 and December 2015. Clinical, pathological, and immunohistochemical staining features are discussed. Each tumor was composed of undifferentiated carcinoma (UC) and low-grade endometrioid carcinoma with abrupt transition between them. Two patients showed recurrence or progression within one month postoperatively and died at the last follow-up. An immunohistochemical study showed PAX-8, ER, PR, and E-cadherin expression in UC component.


DEAC should not be underdiagnosed as conventional endometrioid adenocarcinoma due to its fulminant clinical course. Therefore, UC, including DEAC, should be further categorized to provide intensive treatment to improve patient survival.
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