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Erschienen in: Der Nervenarzt 1/2012

01.01.2012 | Übersichten

„Default-mode“-Netzwerk des Gehirns

Neurobiologie und klinische Bedeutung

verfasst von: A. Otti, H. Gündel, A. Wohlschläger, C. Zimmer, C. Sorg, M. Noll-Hussong

Erschienen in: Der Nervenarzt | Ausgabe 1/2012

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Zusammenfassung

Der Ruhezustand des menschlichen Gehirns ist durch die intrinsische Aktivität des „Default-mode“-Netzwerks (DMN), das sowohl kortikale Mittellinienstrukturen als auch laterale parietale und temporale Anteile umfasst, geprägt. Dieses System ist während des selbstorientierten Denkens, wie z. B. im Ruhezustand, aktiv, während eines weltorientierten Bewusstseinszustands, wie z. B. während externaler Aufmerksamkeit und spezifischer kognitiver Aufgaben, jedoch in seiner Aktivität gemindert. Ausgehend von der historischen und methodischen Entwicklung des DMN-Modells beschreibt der vorliegende Übersichtsbeitrag zunächst die funktionelle Anatomie und potenzielle Funktionen dieses neuralen Systems. Im Anschluss werden, basierend auf der aktuellen Datenlage, die klinischen Implikationen einer gestörten Netzwerkstruktur beleuchtet und die Rolle des DMN bei verschiedenen psychischen Störungen aufgezeigt.
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Metadaten
Titel
„Default-mode“-Netzwerk des Gehirns
Neurobiologie und klinische Bedeutung
verfasst von
A. Otti
H. Gündel
A. Wohlschläger
C. Zimmer
C. Sorg
M. Noll-Hussong
Publikationsdatum
01.01.2012
Verlag
Springer-Verlag
Erschienen in
Der Nervenarzt / Ausgabe 1/2012
Print ISSN: 0028-2804
Elektronische ISSN: 1433-0407
DOI
https://doi.org/10.1007/s00115-011-3307-6

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