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European Journal of Nutrition

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01.10.2008 | ORIGINAL CONTRIBUTION

Dehydroepiandrosterone (DHEA) prevents the prostanoid imbalance in mesenteric bed of fructose-induced hypertensive rats

verfasst von: Horacio A. Peredo, Marcos Mayer, Ileana R. Faya, Ana M. Puyó, Andrea Carranza

Erschienen in: European Journal of Nutrition | Ausgabe 7/2008

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Abstract

Background

In previous studies we reported an altered prostanoid (PR) release-pattern in mesenteric vessels in fructose (F)-overloaded rats, an experimental model of insulin resistance and hypertension. Dehydroepiandrosterone (DHEA) and its precursor Dehydroepiandrosterone sulfate (DHEA-S) are the most abundant circulating steroid hormones produced by the adrenal and recent studies in both cells and animals suggest that DHEA may have acute non-genomic actions that mimic both metabolic and vascular actions of insulin.

Aim of the study

This study was to analyze in F-overloaded rats, the effects of DHEA treatment on arterial blood pressure and the PR production in mesenteric vessels and aorta.

Methods

Male 6 week-old Sprague–Dawley rats were randomly divided in four groups: a control group (C), a DHEA (30 mg/kg/sc/48 h)-treated group (D), a fructose (10% w/v in drinking water)-fed group (F), and both treatments simultaneously group (FD). The systolic blood pressure (SBP) was measured by tail cuff method and glycemia and triglyderidemia were measured by enzymatic assays. The mesenteric beds of all groups were dissected, and incubated in Krebs solution. The PR released were measured by HPLC.

Results

F overload increased SBP and triglyceridemia and decreased the mesenteric vasodilatory PR release. DHEA treatment prevented the increment in SBP and triglyceridemia and decreased vasoconstrictor PR in F-treated rats.

Conclusion

DHEA normalize the PGI₂/TX ratio, diminished in F-overloaded rats, through the decrease in thromboxane (TX) production and this could be one of the mechanisms by which DHEA prevented the slight hypertension in F-animals.

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Titel: Dehydroepiandrosterone (DHEA) prevents the prostanoid imbalance in mesenteric bed of fructose-induced hypertensive rats
verfasst von: Horacio A. Peredo
Marcos Mayer
Ileana R. Faya
Ana M. Puyó
Andrea Carranza
Publikationsdatum: 01.10.2008
Verlag: D. Steinkopff-Verlag
Erschienen in: European Journal of Nutrition / Ausgabe 7/2008
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-008-0734-7

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Dehydroepiandrosterone (DHEA) prevents the prostanoid imbalance in mesenteric bed of fructose-induced hypertensive rats

Abstract

Background

Aim of the study

Methods

Results

Conclusion

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Parodontalbehandlung verbessert Prognose bei Katheterablation

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Background

Aim of the study

Methods

Results

Conclusion

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