Skip to main content
main-content

21.01.2017 | HIV Pathogenesis and Treatment (AL Landay and N Utay, Section Editors) | Ausgabe 1/2017

Current HIV/AIDS Reports 1/2017

Dendritic Cell Immune Responses in HIV-1 Controllers

Zeitschrift:
Current HIV/AIDS Reports > Ausgabe 1/2017
Autoren:
Enrique Martin-Gayo, Xu G. Yu
Wichtige Hinweise
This article is part of the Topical Collection on HIV Pathogenesis and Treatment

Abstract

Purpose of Review

Robust HIV-1-specific CD8 T cell responses are currently regarded as the main correlate of immune defense in rare individuals who achieve natural, drug-free control of HIV-1; however, the mechanisms that support evolution of such powerful immune responses are not well understood. Dendritic cells (DCs) are specialized innate immune cells critical for immune recognition, immune regulation, and immune induction, but their possible contribution to HIV-1 immune defense in controllers remains ill-defined.

Recent Findings

Recent studies suggest that myeloid DCs from controllers have improved abilities to recognize HIV-1 through cytoplasmic immune sensors, resulting in more potent, cell-intrinsic type I interferon secretion in response to viral infection. This innate immune response may facilitate DC-mediated induction of highly potent antiviral HIV-1-specific T cells. Moreover, protective HLA class I isotypes restricting HIV-1-specific CD8 T cells may influence DC function through specific interactions with innate myelomonocytic MHC class I receptors from the leukocyte immunoglobulin-like receptor family.

Summary

Bi-directional interactions between dendritic cells and HIV-1-specific T cells may contribute to natural HIV-1 immune control, highlighting the importance of a fine-tuned interplay between innate and adaptive immune activities for effective antiviral immune defense.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Weitere Produktempfehlungen anzeigen
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2017

Current HIV/AIDS Reports 1/2017 Zur Ausgabe

Behavioral-Bio-Medical Interface (JL Brown and RJ DiClemente, Section Editors)

Healthy Aging in Older Women Living with HIV Infection: a Systematic Review of Psychosocial Factors

Behavioral-Bio-Medical Interface (JL Brown and RJ DiClemente, Section Editors)

Faces of Frailty in Aging with HIV Infection

HIV Pathogenesis and Treatment (AL Landay and N Utay, Section Editors)

Interventions for Neurocognitive Dysfunction

  1. Das kostenlose Testabonnement läuft nach 14 Tagen automatisch und formlos aus. Dieses Abonnement kann nur einmal getestet werden.

  2. Das kostenlose Testabonnement läuft nach 14 Tagen automatisch und formlos aus. Dieses Abonnement kann nur einmal getestet werden.