Introduction
Methods
Data on Depression
SNPs | Beta | SE | P value | Beta | SE | P value | Beta | SE | P value | Beta | SE | P value | Beta | SE | P value | Beta | SE | P value |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Depression | FA-BMD | FN-BMD | LS-BMD | HE-BMD | Fracture | |||||||||||||
rs301799 | − 0.025 | 0.0035 | 1.36E-12 | − 0.0264 | 0.01593 | 0.1036 | − 0.0203 | 0.00757 | 0.00866 | − 0.0239 | 0.00883 | 0.00835 | − 0.0246 | 0.00186 | 4.80E−34 | − 0.0026 | 0.00665 | 0.7 |
rs1002656 | − 0.0266 | 0.0038 | 3.74E-12 | 0.02817 | 0.01683 | 0.10079 | − 0.0035 | 0.00816 | 0.67805 | − 0.0126 | 0.00949 | 0.19541 | 0.00063 | 0.00202 | 0.38 | 0.00229 | 0.00721 | 0.74 |
rs1466887 | − 0.0199 | 0.0036 | 4.12E-08 | − 0.0256 | 0.01561 | 0.10816 | − 0.0107 | 0.00758 | 0.16809 | − 0.0084 | 0.00883 | 0.35019 | − 0.0004 | 0.00185 | 0.96 | 0.00042 | 0.00662 | 1 |
rs11579246 | 0.0381 | 0.0061 | 5.71E-10 | 0.00879 | 0.0267 | 0.74675 | − 0.0082 | 0.01278 | 0.52944 | 0.00323 | 0.01487 | 0.8321 | 0.00045 | 0.00323 | 0.75 | − 0.0026 | 0.01155 | 0.84 |
rs1890946 | − 0.0235 | 0.0035 | 2.68E-11 | 0.0037 | 0.01568 | 0.81703 | − 0.0112 | 0.00751 | 0.14335 | − 0.0196 | 0.00877 | 0.02921 | − 0.001 | 0.00184 | 0.8 | − 6E-06 | 0.00657 | 0.96 |
rs10789214 | 0.0193 | 0.0035 | 4.44E-08 | 0.00242 | 0.01606 | 0.88267 | − 0.0104 | 0.00763 | 0.18399 | − 0.0181 | 0.00894 | 0.04838 | − 0.0135 | 0.00185 | 4.00E−09 | 0.0273 | 0.00661 | 3.60E−05 |
rs2568958 | 0.0373 | 0.0036 | 8.47E-25 | 0.01024 | 0.01613 | 0.53362 | 0.00867 | 0.00774 | 0.27272 | − 0.0047 | 0.00902 | 0.61 | 0.00953 | 0.00187 | 0.00013 | − 0.0017 | 0.00667 | 0.93 |
rs113188507 | 0.0221 | 0.0039 | 1.87E-08 | 0.01278 | 0.01745 | 0.47283 | − 0.0047 | 0.00837 | 0.58383 | − 0.0117 | 0.00978 | 0.24412 | − 0.0064 | 0.00201 | 0.004 | 0.00753 | 0.00716 | 0.28 |
rs10913112 | − 0.0264 | 0.0036 | 3.4E-13 | − 0.0225 | 0.01605 | 0.16909 | − 0.002 | 0.00779 | 0.80043 | − 0.0117 | 0.00909 | 0.20807 | 0.00537 | 0.00189 | 0.0038 | 0.0032 | 0.00675 | 0.69 |
rs17641524 | − 0.032 | 0.0043 | 1.52E-13 | − 0.0151 | 0.01922 | 0.44162 | − 0.0031 | 0.00909 | 0.74048 | − 0.0008 | 0.01052 | 0.9424 | − 0.0025 | 0.00225 | 0.53 | − 0.0114 | 0.00803 | 0.16 |
rs12052908 | − 0.022 | 0.0035 | 4.44E-10 | − 0.0107 | 0.01589 | 0.50867 | − 0.0039 | 0.00774 | 0.62409 | − 0.0015 | 0.009 | 0.86921 | 0.00326 | 0.00185 | 0.27 | − 0.0061 | 0.0066 | 0.37 |
rs1568452 | 0.0248 | 0.0036 | 8.12E-12 | 1.7E-05 | 0.01606 | 0.99917 | 0.01164 | 0.00777 | 0.14268 | 0.00475 | 0.00905 | 0.60875 | 0.00608 | 0.00189 | 0.048 | 0.00602 | 0.00674 | 0.33 |
rs7585722 | − 0.0269 | 0.0048 | 2.68E-08 | − 0.0153 | 0.02156 | 0.48689 | 0.01297 | 0.01023 | 0.21485 | 0.00564 | 0.01191 | 0.64353 | − 0.0034 | 0.00254 | 0.19 | − 0.0046 | 0.00909 | 0.61 |
rs1226412 | 0.0256 | 0.0043 | 3.46E-09 | 0.02059 | 0.01899 | 0.28758 | − 0.0003 | 0.00912 | 0.97429 | − 0.004 | 0.01064 | 0.71156 | − 0.0019 | 0.00227 | 0.69 | − 0.0036 | 0.00813 | 0.68 |
rs62188629 | 0.0236 | 0.0038 | 7.13E-10 | − 0.0099 | 0.01664 | 0.56011 | 0.00916 | 0.0081 | 0.2686 | 0.0056 | 0.00941 | 0.5612 | 0.00179 | 0.00198 | 0.41 | 0.0012 | 0.00707 | 0.82 |
rs4346585 | − 0.0236 | 0.0038 | 7.13E-10 | 0.02361 | 0.01758 | 0.18785 | − 0.0015 | 0.00892 | 0.86657 | − 0.0012 | 0.00974 | 0.90609 | _ | _ | _ | _ | _ | _ |
rs141954845 | 0.0229 | 0.0037 | 8.15E-10 | − 0.0493 | 0.02504 | 0.05352 | − 0.009 | 0.01172 | 0.45135 | − 0.0141 | 0.01295 | 0.28695 | _ | _ | _ | _ | _ | _ |
rs6783233 | 0.0218 | 0.0039 | 2.9E-08 | − 0.0236 | 0.01737 | 0.18258 | − 0.0099 | 0.00838 | 0.24801 | − 0.018 | 0.00981 | 0.07242 | 0.00086 | 0.00205 | 0.82 | − 0.0101 | 0.00726 | 0.16 |
rs1095626 | − 0.0264 | 0.0035 | 7.13E-14 | 0.00375 | 0.01646 | 0.8234 | − 0.0026 | 0.00771 | 0.74523 | − 0.0043 | 0.00903 | 0.64485 | − 0.0015 | 0.00187 | 0.27 | − 0.0008 | 0.00663 | 0.93 |
rs7685686 | 0.0202 | 0.0036 | 2.57E-08 | 0.00327 | 0.01606 | 0.84188 | − 0.0057 | 0.00762 | 0.46244 | − 0.0017 | 0.00887 | 0.84855 | − 0.0008 | 0.00187 | 0.98 | − 0.0072 | 0.00663 | 0.31 |
rs34937911 | 0.0304 | 0.0055 | 4.13E-08 | 0.02452 | 0.02456 | 0.32768 | 0.00712 | 0.01165 | 0.55029 | 0.0031 | 0.01355 | 0.82324 | 0.0015 | 0.0029 | 0.93 | 0.00115 | 0.01029 | 0.96 |
rs45510091 | 0.0448 | 0.008 | 1.83E-08 | 0.01463 | 0.03488 | 0.68083 | 0.00875 | 0.01728 | 0.62017 | − 0.0249 | 0.02009 | 0.22638 | − 0.0015 | 0.00403 | 0.28 | − 0.0003 | 0.01428 | 0.95 |
rs35553410 | − 0.0244 | 0.004 | 1.42E-09 | 0.02599 | 0.01766 | 0.149 | 0.00032 | 0.00862 | 0.97139 | − 0.0118 | 0.01002 | 0.25058 | − 0.0034 | 0.00211 | 0.069 | 0.01234 | 0.00749 | 0.096 |
rs7659414 | − 0.0201 | 0.0035 | 1.2E-08 | 0.02273 | 0.01567 | 0.15501 | 0.01486 | 0.00757 | 0.05482 | 0.00727 | 0.00882 | 0.42061 | − 0.0022 | 0.00187 | 0.27 | − 0.0005 | 0.00662 | 0.92 |
rs60157091 | 0.02 | 0.0035 | 1.42E-08 | − 0.0065 | 0.01599 | 0.69031 | − 0.0029 | 0.00764 | 0.70746 | − 0.018 | 0.00892 | 0.04935 | − 0.0054 | 0.00185 | 0.0016 | 0.01408 | 0.00654 | 0.029 |
rs3099439 | − 0.0276 | 0.0035 | 5.05E-15 | 0.0282 | 0.01588 | 0.08158 | 0.00137 | 0.00875 | 0.87804 | − 0.0144 | 0.00938 | 0.13467 | − 0.0014 | 0.00187 | 0.43 | 0.00313 | 0.0066 | 0.63 |
rs10061069 | − 0.0275 | 0.0042 | 8.15E-11 | − 0.0292 | 0.01875 | 0.12668 | − 0.0083 | 0.00906 | 0.36817 | − 0.0074 | 0.01055 | 0.49125 | − 0.0023 | 0.00221 | 0.16 | − 0.001 | 0.00784 | 0.95 |
rs30266 | 0.0308 | 0.0037 | 1.45E-16 | 0.01996 | 0.01655 | 0.23684 | − 0.0098 | 0.008 | 0.23013 | − 0.0063 | 0.00931 | 0.50588 | − 0.0024 | 0.00197 | 0.04 | 0.02085 | 0.00697 | 0.0035 |
rs11135349 | − 0.0295 | 0.0035 | 6.04E-17 | − 0.0502 | 0.01596 | 0.00204 | − 0.0083 | 0.00758 | 0.28481 | − 0.0113 | 0.00883 | 0.21168 | − 0.0016 | 0.00185 | 0.087 | − 0.0006 | 0.00655 | 0.96 |
rs200949 | 0.048 | 0.0053 | 2.53E-19 | 0.05445 | 0.02691 | 0.04732 | − 0.0074 | 0.01191 | 0.544 | 0.0106 | 0.01431 | 0.46792 | − 0.0155 | 0.00261 | 8.40E-09 | 0.00722 | 0.00932 | 0.47 |
rs9363467 | 0.0237 | 0.0036 | 6.44E-11 | 0.00949 | 0.01679 | 0.57962 | 0.00055 | 0.00795 | 0.94645 | 0.00542 | 0.00923 | 0.56652 | _ | _ | _ | _ | _ | _ |
rs7758630 | − 0.0225 | 0.0036 | 5.56E-10 | − 0.0237 | 0.01616 | 0.15097 | − 0.0009 | 0.00774 | 0.90833 | − 0.0095 | 0.00905 | 0.30343 | − 0.0027 | 0.00187 | 0.18 | 0.01485 | 0.00667 | 0.017 |
rs2876520 | − 0.023 | 0.0036 | 2.29E-10 | 0.01863 | 0.01586 | 0.24951 | 0.00354 | 0.00764 | 0.65027 | − 0.0072 | 0.0089 | 0.4267 | − 0.0024 | 0.00185 | 0.28 | − 0.0022 | 0.00662 | 0.76 |
rs725616 | 0.0204 | 0.0036 | 1.87E-08 | 0.01789 | 0.01632 | 0.2825 | 0.01028 | 0.00777 | 0.19568 | 0.02325 | 0.00907 | 0.01232 | 0.0046 | 0.0019 | 0.026 | − 0.0023 | 0.00681 | 0.78 |
rs2029865 | − 0.0201 | 0.0035 | 1.2E-08 | 0.00015 | 0.01588 | 0.99252 | 0.0006 | 0.00754 | 0.93839 | 0.01312 | 0.00879 | 0.14466 | − 0.0004 | 0.00184 | 0.69 | 0.01112 | 0.00657 | 0.088 |
rs3823624 | 0.0272 | 0.0045 | 1.99E-09 | − 0.0037 | 0.0198 | 0.85312 | − 0.0027 | 0.00954 | 0.7833 | − 0.0016 | 0.01109 | 0.88677 | − 0.0073 | 0.00238 | 0.0027 | 0.00413 | 0.00855 | 0.61 |
rs2043539 | 0.0273 | 0.0035 | 9.89E-15 | − 0.0152 | 0.01598 | 0.35191 | 0.00737 | 0.0076 | 0.34314 | 0.01577 | 0.00885 | 0.08185 | 0.0047 | 0.00185 | 0.039 | − 0.0022 | 0.00662 | 0.77 |
rs2247523 | − 0.0207 | 0.0035 | 4.38E-09 | 0.02397 | 0.01573 | 0.13522 | 0.01087 | 0.00753 | 0.1582 | 0.00152 | 0.0088 | 0.8661 | 0.00196 | 0.00183 | 0.65 | 0.01039 | 0.00656 | 0.1 |
rs58104186 | 0.0237 | 0.0035 | 1.82E-11 | 0.01034 | 0.0158 | 0.52106 | 0.01124 | 0.00751 | 0.14328 | 0.01003 | 0.00877 | 0.26397 | 0.00265 | 0.00184 | 0.19 | − 0.0112 | 0.0066 | 0.092 |
rs7837935 | − 0.0292 | 0.0049 | 3.34E-09 | − 0.0538 | 0.0218 | 0.01555 | − 0.0065 | 0.01053 | 0.54684 | − 0.0124 | 0.01252 | 0.33492 | 0.00076 | 0.00253 | 0.72 | 0.00744 | 0.00894 | 0.42 |
rs67436663 | − 0.0259 | 0.0042 | 9.37E-10 | − 0.0365 | 0.035 | 0.30658 | 0.00566 | 0.01649 | 0.73723 | − 0.0329 | 0.01813 | 0.07657 | _ | _ | _ | _ | _ | _ |
rs1354115 | 0.021 | 0.0036 | 7.08E-09 | − 0.0182 | 0.0247 | 0.46894 | 0.01734 | 0.00932 | 0.06883 | 0.02748 | 0.01119 | 0.01646 | − 0.0052 | 0.00192 | 0.045 | 0.00041 | 0.00678 | 0.92 |
rs263645 | 0.0221 | 0.0035 | 3.7E-10 | 0.01283 | 0.01557 | 0.41884 | − 0.0096 | 0.0075 | 0.21017 | 0.00035 | 0.00872 | 0.96841 | − 0.001 | 0.00186 | 0.61 | − 0.0122 | 0.00658 | 0.083 |
rs34653192 | − 0.0229 | 0.0038 | 2.23E-09 | 0.00931 | 0.01685 | 0.01685 | 0.00756 | 0.00812 | 0.36268 | 0.00661 | 0.00947 | 0.4952 | 0.00246 | 0.002 | 0.061 | − 0.0085 | 0.00708 | 0.2 |
rs10817969 | 0.0261 | 0.0039 | 3.11E-11 | _ | _ | _ | − 0.0099 | 0.01554 | 0.53372 | 0.00554 | 0.01904 | 0.77542 | − 0.0032 | 0.00206 | 0.15 | − 0.0065 | 0.00728 | 0.35 |
rs997934 | 0.0198 | 0.0036 | 4.81E-08 | − 0.007 | 0.01585 | 0.66476 | 0.00572 | 0.00771 | 0.46745 | 0.00558 | 0.00896 | 0.54274 | − 0.0007 | 0.0019 | 0.4 | − 0.0078 | 0.00675 | 0.25 |
rs1021363 | 0.0303 | 0.0037 | 4.41E-16 | 0.02478 | 0.0161 | 0.13132 | − 0.0067 | 0.00781 | 0.40034 | − 0.002 | 0.00909 | 0.83214 | − 0.0026 | 0.00192 | 0.2 | 0.0101 | 0.00683 | 0.14 |
rs1448938 | 0.0214 | 0.0035 | 1.3E-09 | 0.00077 | 0.01591 | 0.96215 | 0.01071 | 0.00763 | 0.16948 | 0.03221 | 0.00889 | 0.00041 | 0.0087 | 0.00186 | 4.50E-05 | − 0.0218 | 0.00662 | 0.0011 |
rs2509805 | 0.022 | 0.0038 | 9.17E-09 | 0.02034 | 0.01704 | 0.24191 | 0.02674 | 0.00869 | 0.00263 | 0.00512 | 0.0095 | 0.59892 | 0.00953 | 0.00198 | 0.00024 | − 0.0055 | 0.00702 | 0.4 |
rs198457 | − 0.0292 | 0.0046 | 2.99E-10 | − 0.0022 | 0.02051 | 0.91518 | − 0.0026 | 0.00969 | 0.79206 | − 0.0026 | 0.01132 | 0.8199 | − 0.0094 | 0.00237 | 6.00E-04 | 0.01139 | 0.00843 | 0.18 |
rs7932640 | 0.0281 | 0.0035 | 1.62E-15 | − 0.017 | 0.01605 | 0.29952 | − 0.0025 | 0.00762 | 0.75202 | − 0.0013 | 0.00887 | 0.88201 | 0.00791 | 0.00186 | 6.00E-04 | 0.00057 | 0.00663 | 0.93 |
rs61902811 | − 0.0257 | 0.0036 | 1.4E-12 | − 0.0233 | 0.01594 | 0.15229 | − 0.0202 | 0.0077 | 0.01031 | − 0.0183 | 0.00895 | 0.04618 | 0.00341 | 0.00191 | 0.069 | − 0.0011 | 0.00678 | 0.88 |
rs57344483 | − 0.038 | 0.0068 | 1.82E-08 | − 0.0227 | 0.02863 | 0.43741 | − 0.034 | 0.01404 | 0.01404 | − 0.014 | 0.01626 | 0.40155 | 0.00054 | 0.00349 | 0.47 | 0.015 | 0.01241 | 0.18 |
rs78337797 | 0.0306 | 0.0055 | 3.37E-08 | 0.00291 | 0.02436 | 0.90687 | 0.002 | 0.0121 | 0.87131 | 0.01798 | 0.01409 | 0.21268 | 0.00024 | 0.00283 | 0.66 | − 0.0163 | 0.01002 | 0.11 |
rs56314503 | − 0.0254 | 0.004 | 2.95E-10 | 0.00461 | 0.01848 | 0.80687 | − 0.0128 | 0.0087 | 0.14904 | − 0.0004 | 0.01012 | 0.96604 | − 0.0004 | 0.0022 | 0.74 | − 0.0065 | 0.00781 | 0.45 |
rs10774600 | − 0.0267 | 0.0048 | 3.39E-08 | − 0.015 | 0.02151 | 0.49556 | − 0.0076 | 0.01027 | 0.46869 | − 0.0019 | 0.01198 | 0.87633 | − 0.0022 | 0.00254 | 0.58 | − 0.0175 | 0.00898 | 0.05 |
rs3213572 | 0.0217 | 0.0035 | 7.61E-10 | 0.0188 | 0.01599 | 0.24878 | − 0.0005 | 0.0076 | 0.95115 | 0.00525 | 0.00886 | 0.56296 | − 0.0056 | 0.00185 | 0.0067 | 0.00642 | 0.00655 | 0.29 |
rs1409379 | 0.0249 | 0.0041 | 1.67E-09 | − 0.046 | 0.01822 | 0.01325 | − 0.0009 | 0.00885 | 0.91719 | 0.00369 | 0.01035 | 0.72778 | − 0.0104 | 0.00218 | 1.10E-05 | 0.00443 | 0.0077 | 0.57 |
rs1343605 | 0.0313 | 0.0036 | 6.23E-18 | 0.01126 | 0.01629 | 0.49772 | − 0.0117 | 0.00777 | 0.14229 | − 0.0149 | 0.00909 | 0.10983 | − 0.0055 | 0.00192 | 0.00054 | 0.00316 | 0.00678 | 0.57 |
rs9592461 | 0.0216 | 0.0035 | 9.1E-10 | − 0.0251 | 0.01568 | 0.11596 | 0.00195 | 0.00746 | 0.79799 | − 0.0038 | 0.0087 | 0.67332 | 0.00186 | 0.00186 | 0.26 | 0.00784 | 0.00654 | 0.29 |
rs9545360 | − 0.0271 | 0.0046 | 5.02E-09 | 0.00039 | 0.02007 | 0.98481 | − 0.0062 | 0.0097 | 0.53208 | − 0.0115 | 0.01126 | 0.31934 | 0.00137 | 0.0024 | 0.76 | 0.00857 | 0.00847 | 0.35 |
rs4772087 | 0.0227 | 0.0036 | 3.91E-10 | − 0.0068 | 0.01605 | 0.67583 | − 0.0088 | 0.00827 | 0.29778 | − 0.0031 | 0.00903 | 0.7377 | − 0.0039 | 0.00192 | 0.11 | − 0.0059 | 0.00676 | 0.37 |
rs61990288 | − 0.026 | 0.0035 | 1.68E-13 | 0.02428 | 0.01566 | 0.12827 | 0.00424 | 0.00752 | 0.58132 | 0.01666 | 0.00877 | 0.06347 | 0.00265 | 0.00186 | 0.37 | 0.00867 | 0.00655 | 0.21 |
rs1956373 | − 0.0226 | 0.004 | 2.06E-08 | 0.00262 | 0.01809 | 0.88722 | 0.01594 | 0.00859 | 0.06935 | 0.01084 | 0.01001 | 0.29047 | − 0.0001 | 0.00215 | 0.69 | 0.00874 | 0.00757 | 0.26 |
rs1045430 | − 0.0253 | 0.0035 | 7.31E-13 | − 0.017 | 0.01574 | 0.01574 | − 0.0024 | 0.00752 | 0.75718 | − 0.0006 | 0.0087 | 0.94807 | − 0.0061 | 0.00185 | 0.0012 | 0.00033 | 0.00653 | 0.96 |
rs10149470 | − 0.0267 | 0.0035 | 3.72E-14 | 0.00896 | 0.01552 | 0.01552 | 0.00388 | 0.00757 | 0.61581 | 0.01119 | 0.00882 | 0.21519 | 0.0036 | 0.00186 | 0.11 | − 0.0003 | 0.00655 | 0.98 |
rs8037355 | − 0.0233 | 0.0035 | 3.94E-11 | − 0.0221 | 0.01567 | 0.1673 | 0.00688 | 0.00756 | 0.37297 | − 0.0216 | 0.00882 | 0.01694 | 0.00159 | 0.00186 | 0.46 | − 0.0197 | 0.00804 | 0.014 |
rs34488670 | − 0.0252 | 0.0043 | 6.03E-09 | 0.01255 | 0.0193 | 0.52388 | − 0.0068 | 0.00916 | 0.46635 | 0.00959 | 0.0107 | 0.38127 | 0.00116 | 0.00228 | 0.7 | 0.00697 | 0.00706 | 0.32 |
rs7193263 | − 0.0239 | 0.0038 | 4.33E-10 | 0.01443 | 0.01679 | 0.39933 | − 0.0065 | 0.00798 | 0.00798 | 0.00535 | 0.00927 | 0.57319 | − 0.0015 | 0.002 | 0.75 | − 0.0022 | 0.00678 | 0.82 |
rs7198928 | 0.0239 | 0.0036 | 4.45E-11 | − 0.0294 | 0.01566 | 0.06585 | − 0.0202 | 0.00765 | 0.00975 | − 0.013 | 0.00889 | 0.1529 | − 0.0033 | 0.00192 | 0.065 | 0.00223 | 0.00678 | 0.82 |
rs12923444 | − 0.0214 | 0.0035 | 1.3E-09 | 0.01766 | 0.01556 | 0.26598 | 0.00172 | 0.00755 | 0.82395 | − 0.0024 | 0.00879 | 0.788 | 0.0063 | 0.00186 | 0.00045 | − 0.0017 | 0.00658 | 0.78 |
rs75581564 | 0.0301 | 0.0054 | 3.17E-08 | − 0.0287 | 0.02411 | 0.24268 | − 0.0029 | 0.01181 | 0.80805 | − 0.005 | 0.01377 | 0.72061 | − 0.0016 | 0.00283 | 0.41 | 0.00388 | 0.01001 | 0.71 |
rs12967855 | 0.0265 | 0.0037 | 1.18E-12 | − 0.0164 | 0.01669 | 0.33618 | 0.00124 | 0.00801 | 0.87936 | − 0.0167 | 0.00936 | 0.08202 | − 0.0055 | 0.00198 | 0.013 | 0.00095 | 0.00698 | 0.89 |
rs7227069 | 0.0238 | 0.0035 | 1.5E-11 | − 0.0047 | 0.01614 | 0.7747 | 0.00273 | 0.00765 | 0.72747 | − 0.0106 | 0.00894 | 0.2479 | − 0.0029 | 0.00188 | 0.078 | 0.00769 | 0.00662 | 0.24 |
rs12966052 | − 0.0314 | 0.0046 | 1.25E-11 | − 0.0266 | 0.02022 | 0.19715 | − 0.0153 | 0.00973 | 0.12333 | − 0.007 | 0.01133 | 0.54609 | 0.00175 | 0.00241 | 0.55 | − 0.0054 | 0.00848 | 0.52 |
rs7241572 | 0.028 | 0.0044 | 2.7E-10 | 0.03054 | 0.03054 | 0.12563 | 0.01589 | 0.00959 | 0.10503 | 0.00952 | 0.01121 | 0.40695 | 0.00637 | 0.00232 | 0.0018 | 0.00917 | 0.00815 | 0.23 |
rs33431 | 0.0198 | 0.0036 | 4.81E-08 | 0.01177 | 0.01593 | 0.46893 | 0.0009 | 0.00766 | 0.90848 | − 0.0083 | 0.0089 | 0.36478 | 0.00112 | 0.00192 | 0.89 | 0.01221 | 0.00677 | 0.067 |
rs143186028 | 0.0277 | 0.0046 | 2.29E-09 | − 0.0153 | 0.02044 | 0.46353 | 0.00894 | 0.01062 | 0.41034 | − 0.0048 | 0.0116 | 0.68915 | _ | _ | _ | _ | _ | _ |
rs5995992 | − 0.0266 | 0.0039 | 1.3E-11 | − 0.0215 | 0.01823 | 0.24781 | − 0.0131 | 0.01029 | 0.21159 | 0.00548 | 0.01176 | 0.64907 | − 0.0123 | 0.00206 | 9.80E-10 | 0.00483 | 0.00723 | 0.5 |
Data on BMD and Fracture
Statistical Analyses
Sensitivity Analyses
Results
Causal Effect of Depression on FA-BMD, FN-BMD and LS-BMD
Variables | IVW | Weighted median | MR-Egger | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Estimate | SE | 95% CI | P value | Q value | I2 | Heterogeneity P value | Estimate | SE | 95% CI | P value | Estimate | SE | 95% CI | P value | Intercept | SE | 95% CI | Pleiotropy P value | |
FA-BMD | 0.091 | 0.091 | − 0.088,0.269 | 0.320 | 103.801 | 25.80% | 0.023 | 0.144 | 0.120 | − 0.092,0.380 | 0.231 | 1.335 | 0.516 | − 0.324,2.347 | 0.010 | − 0.032 | 0.013 | − 0.058,-0.006 | 0.014 |
FN-BMD | 0.066 | 0.042 | − 0.016,0.148 | 0.113 | 96.598 | 19.30% | 0.075 | 0.070 | 0.056 | − 0.040,0.180 | 0.215 | 0.239 | 0.243 | − 0.237,0.714 | 0.326 | − 0.004 | 0.006 | − 0.017,0.008 | 0.471 |
LS-BMD | 0.074 | 0.052 | − 0.029,0.177 | 0.159 | 112.741 | 30.80% | 0.006 | 0.068 | 0.066 | − 0.061,0.197 | 0.302 | 0.083 | 0.308 | − 0.520,0.686 | 0.787 | 0.000 | 0.008 | − 0.016,0.015 | 0.976 |
HE-BMD | 0.009 | 0.027 | − 0.043,0.061 | 0.727 | 600.806 | 87.80% | < 0.0001 | − 0.001 | 0.017 | − 0.034,0.033 | 0.976 | 0.038 | 0.150 | − 0.256,0.333 | 0.798 | − 0.001 | 0.004 | − 0.008,0.007 | 0.844 |
Fracture | 0.008 | 0.041 | − 0.071,0.087 | 0.844 | 110.664 | 34.00% | 0.029 | 0.020 | 0.049 | − 0.075,0.115 | 0.680 | 0.122 | 0.229 | − 0.326,0.571 | 0.593 | − 0.003 | 0.006 | − 0.014,0.008 | 0.612 |
Causal Effect of Depression on HE-BMD and Fracture
Evaluation of Assumptions and Sensitivity Analyses
Variables | Estimate | SE | 95% CI | P value |
---|---|---|---|---|
HE-BMD excluding rs301799, rs10789214, rs2568958, rs1568452, rs200949, rs3823624, rs1448938, rs2509805, rs198457, rs7932640, rs1409379, rs1343605, rs12923444, rs5995992 | − 0.017 | 0.016 | − 0.048,0.014 | 0.292 |
Fracture excluding rs1448938, rs10789214 | 0.007 | 0.036 | − 0.064,0.077 | 0.855 |