nach oben

Der Nervenarzt

Erschienen in:

23.11.2015 | Übersichten

Depression und Epilepsie

Zwei Krankheitsbilder mit gemeinsamen Ursachen?

verfasst von: Dr. M. Borgmann, Prof. Dr. M. Holtkamp, PD Dr. M. Adli, Prof. Dr. J. Behr

Erschienen in: Der Nervenarzt | Ausgabe 7/2016

Einloggen, um Zugang zu erhalten

Zusammenfassung

Hintergrund

Epilepsien und depressive Störungen zeigen eine hohe Komorbiditätsrate. Daher werden neurobiologische Gemeinsamkeiten sowie ein bidirektionaler Zusammenhang hinsichtlich der Ätiopathogenese angenommen.

Ziel der Arbeit

Das Ziel der Arbeit ist die Darstellung der neurobiologischen Gemeinsamkeiten beider Erkrankungen, die Charakterisierung ihres bidirektionalen ätiologischen Zusammenhangs sowie die Diskussion der therapeutischen Konsequenzen.

Material und Methoden

Es wurde eine Literaturrecherche durchgeführt und Arbeiten über die Interaktion von Depressionen und Epilepsien ausgewertet.

Ergebnisse und Diskussion

Epilepsien und depressive Störungen zeigen einige gemeinsame neurobiologische Merkmale. Bei Patienten mit Epilepsie sollte eine Depression früh und verlässlich erkannt werden, da die erfolgreiche Behandlung Einfluss auf die Prognose, die Lebensqualität und das erhöhte Suizidrisiko der Erkrankten hat. Eine antidepressive Therapie mit noradrenergen spezifisch serotonergen Antidepressiva (NaSSA) oder selektiven Serotonin-Reuptake-Inhibitoren (SSRI) hat im therapeutischen Dosisbereich kein klinisch relevantes epileptogenes Potenzial. Sie steigert jedoch häufig die Lebensqualität und könnte zudem antikonvulsive Effekte bei Patienten mit Epilepsie zu haben. Clomipramin, Bupropion und Maprotilin sollten bei Patienten mit bekannter Epilepsie aufgrund ihrer die Anfallsschwelle senkenden Eigenschaft vermieden werden.

Alper K, Schwartz KA, Kolts RL, Khan A (2007) Seizure incidence in psychopharmacological clinical trials: an analysis of Food and Drug Administration (FDA) summary basis of approval reports. Biol Psychiatry 62(4):345–354PubMedCrossRef

Amiri M, Hansen CP (2015) The interictal dysphoric disorder in patients with epilepsy: A doubtful disorder lacking diagnostic tools. Seizure 24:70–76PubMedCrossRef

Bender RE, Alloy LB (2011) Life stress and kindling in bipolar disorder: review of the evidence and integration with emerging biopsychosocial theories. Clin Psychol Rev 31(3):383–398PubMedPubMedCentralCrossRef

Blumer D, Montouris G, Hermann B (1995) Psychiatric morbidity in seizure patients on a neurodiagnostic monitoring unit. J Neuropsychiatry Clin Neurosci 7(4):445–456PubMedCrossRef

Boylan LS, Flint LA, Labovitz DL, Jackson SC, Starner K, Devinsky O (2004) Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy. Neurology 62(2):258–261PubMedCrossRef

Bremner JD, Narayan M, Anderson ER, Staib LH, Miller HL, Charney DS (2000) Hippocampal volume reduction in major depression. Am J Psychiatry 157(1):115–118PubMedCrossRef

Bremner JD, Vythilingam M, Vermetten E et al (2002) Reduced volume of orbitofrontal cortex in major depression. Biol Psychiatry 51(4):273–279PubMedCrossRef

Cardamone L, Salzberg MR, O’Brien TJ, Jones NC (2013) Antidepressant therapy in epilepsy: can treating the comorbidities affect the underlying disorder? Br J Pharmacol 168(7):1531–1554PubMedPubMedCentralCrossRef

Clinckers R, Smolders I, Meurs A, Ebinger G, Michotte Y (2004) Anticonvulsant action of hippocampal dopamine and serotonin is independently mediated by D and 5-HT receptors. J Neurochem 89(4):834–843PubMedCrossRef

10.

Coffey CE (1994) The role of structural brain imaging in ECT. Psychopharmacol Bull 30(3):477–483PubMed

11.

Danzer SC (2012) Depression, stress, epilepsy and adult neurogenesis. Exp Neurol 233(1):22–32PubMedCrossRef

12.

Drevets WC, Thase ME, Moses-Kolko EL et al (2007) Serotonin-1A receptor imaging in recurrent depression: replication and literature review. Nucl Med Biol 34(7):865–877PubMedPubMedCentralCrossRef

13.

Dudek FE, Sutula TP (2007) Epileptogenesis in the dentate gyrus: a critical perspective. Prog Brain Res 163:755–773PubMedCrossRef

14.

Gilliam F, Kanner AM (2002) Treatment of depressive disorders in epilepsy patients. Epilepsy Behav 3(5S):2–9PubMedCrossRef

15.

Gilling KE, Oltmanns F, Behr J (2013) Impaired maturation of serotonergic function in the dentate gyrus associated with epilepsy. Neurobiol Dis 50:86–95PubMedCrossRef

16.

Giovacchini G, Toczek MT, Bonwetsch R et al (2005) 5-HT 1A receptors are reduced in temporal lobe epilepsy after partial-volume correction. J Nucl Med 46(7):1128–1135PubMedPubMedCentral

17.

Hannon J, Hoyer D (2008) Molecular biology of 5-HT receptors. Behav Brain Res 195(1):198–213PubMedCrossRef

18.

Harris EC, Barraclough B (1997) Suicide as an outcome for mental disorders. A meta-analysis. Br J Psychiatry 170:205–228PubMedCrossRef

19.

Hasler G, Bonwetsch R, Giovacchini G et al (2007) 5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depression. Biol Psychiatry 62(11):1258–1264PubMedPubMedCentralCrossRef

20.

Hernandez EJ, Williams PA, Dudek FE (2002) Effects of fluoxetine and TFMPP on spontaneous seizures in rats with pilocarpine-induced epilepsy. Epilepsia 43(11):1337–1345PubMedCrossRef

21.

Hesdorffer DC, Hauser WA, Annegers JF, Cascino G (2000) Major depression is a risk factor for seizures in older adults. Ann Neurol 47(2):246–249PubMedCrossRef

22.

Hitiris N, Mohanraj R, Norrie J, Sills GJ, Brodie MJ (2007) Predictors of pharmacoresistant epilepsy. Epilepsy Res 75(2–3):192–196PubMedCrossRef

23.

Hoppe C, Elger CE (2011) Depression in epilepsy: a critical review from a clinical perspective. Nat Rev Neurol 7(8):462–472PubMedCrossRef

24.

Iijima M, Ito A, Kurosu S, Chaki S (2010) Pharmacological characterization of repeated corticosterone injection-induced depression model in rats. Brain Res 1359:75–80PubMedCrossRef

25.

Jobe PC, Browning RA (2005) The serotonergic and noradrenergic effects of antidepressant drugs are anticonvulsant, not proconvulsant. Epilepsy Behav 7(4):602–619PubMedCrossRef

26.

Jones NC, Lee HE, Yang M et al (2013) Repeatedly stressed rats have enhanced vulnerability to amygdala kindling epileptogenesis. Psychoneuroendocrinology 38(2):263–270PubMedCrossRef

27.

Jørgensen H, Knigge U, Kjaer A, Vadsholt T, Warberg J (1998) Serotonergic involvement in stress-induced ACTH release. Brain Res 811(1–2):10–20PubMedCrossRef

28.

Kanner AM (2003) Depression in epilepsy: prevalence, clinical semiology, pathogenic mechanisms, and treatment. Biol Psychiatry 54(3):388–398PubMedCrossRef

29.

Kanner AM (2011) Depression and epilepsy: A bidirectional relation? Epilepsia 52(Suppl 1):21–27PubMedCrossRef

30.

Kanner AM, Balabanov A (2002) Depression and epilepsy: how closely related are they? Neurology 58(8 Suppl 5):S27–S39PubMedCrossRef

31.

Kanner AM, Mazarati A, Koepp M (2014) Biomarkers of epileptogenesis: psychiatric comorbidities (?). Neurotherapeutics 11(2):358–372PubMedPubMedCentralCrossRef

32.

Kanner AM, Trimble M, Schmitz B (2010) Postictal affective episodes. Epilepsy Behav 19(2):156–158PubMedCrossRef

33.

Karst H, de Kloet ER, Joëls M (1999) Episodic corticosterone treatment accelerates kindling epileptogenesis and triggers long-term changes in hippocampal CA1 cells, in the fully kindled state. Eur J Neurosci 11(3):889–898PubMedCrossRef

34.

Kauffman RP, Castracane VD, White DL, Baldock SD, Owens R (2005) Impact of the selective serotonin reuptake inhibitor citalopram on insulin sensitivity, leptin and basal cortisol secretion in depressed and non-depressed euglycemic women of reproductive age. Gynecol Endocrinol 21(3):129–137PubMedCrossRef

35.

Koe AS, Salzberg MR, Morris MJ, O’Brien TJ, Jones NC (2014) Early life maternal separation stress augmentation of limbic epileptogenesis: the role of corticosterone and HPA axis programming. Psychoneuroendocrinology 42:124–133PubMedCrossRef

36.

Kumar G, Couper A, O’Brien TJ et al (2007) The acceleration of amygdala kindling epileptogenesis by chronic low-dose corticosterone involves both mineralocorticoid and glucocorticoid receptors. Psychoneuroendocrinology 32(7):834–842PubMedCrossRef

37.

Kumar G, Jones NC, Morris MJ, Rees S, O’Brien TJ, Salzberg MR (2011) Early life stress enhancement of limbic epileptogenesis in adult rats: mechanistic insights. PLoS One 6(9):e24033PubMedPubMedCentralCrossRef

38.

Lee AL, Ogle WO, Sapolsky RM (2002) Stress and depression: possible links to neuron death in the hippocampus. Bipolar Disord 4(2):117–128PubMedCrossRef

39.

Lee KC, Finley PR, Alldredge BK (2003) Risk of seizures associated with psychotropic medications: emphasis on new drugs and new findings. Expert Opin Drug Saf 2(3):233–247PubMedCrossRef

40.

Li Y, Luikart BW, Birnbaum S et al (2008) TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron 59(3):399–412PubMedPubMedCentralCrossRef

41.

Lladó-Pelfort L, Assié M-B, Newman-Tancredi A, Artigas F, Celada P (2010) Preferential in vivo action of F15599, a novel 5-HT(1A) receptor agonist, at postsynaptic 5-HT(1A) receptors. Br J Pharmacol 160(8):1929–1940PubMedPubMedCentralCrossRef

42.

Lok A, Mocking RJT, Ruhé HG et al (2012) Longitudinal hypothalamic-pituitary-adrenal axis trait and state effects in recurrent depression. Psychoneuroendocrinology 37(7):892–902PubMedCrossRef

43.

López JF, Chalmers DT, Little KY, Watson SJ (1998) A.E. Bennett Research Award. Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression. Biol Psychiatry 43(8):547–573PubMedCrossRef

44.

Lothe A, Didelot A, Hammers A et al (2008) Comorbidity between temporal lobe epilepsy and depression: a [18F]MPPF PET study. Brain 131(Pt 10):2765–2782PubMedCrossRef

45.

Maccotta L, He BJ, Snyder AZ et al (2013) Impaired and facilitated functional networks in temporal lobe epilepsy. Neuroimage Clin 2:862–872PubMedPubMedCentralCrossRef

46.

Maccotta L, Moseley ED, Benzinger TL, Hogan RE (2015) Beyond the CA1 subfield: Local hippocampal shape changes in MRI-negative temporal lobe epilepsy. Epilepsia 56(5):780–788PubMedPubMedCentralCrossRef

47.

Maguire MJ, Weston J, Singh J, Marson AG (2014) Antidepressants for people with epilepsy and depression. Cochrane Database Syst Rev 12:CD010682PubMed

48.

Mahar I, Bambico FR, Mechawar N, Nobrega JN (2014) Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects. Neurosci Biobehav Rev 38:173–192PubMedCrossRef

49.

Malberg JE, Duman RS (2003) Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology 28(9):1562–1571PubMedCrossRef

50.

Marco EM, Scattoni ML, Rapino C et al (2013) Emotional, endocrine and brain anandamide response to social challenge in infant male rats. Psychoneuroendocrinology 38(10):2152–2162PubMedCrossRef

51.

Mazarati AM, Shin D, Kwon YS et al (2009) Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy. Neurobiol Dis 34(3):457–461PubMedPubMedCentralCrossRef

52.

Mazarati A, Siddarth P, Baldwin RA, Shin D, Caplan R, Sankar R (2008) Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine. Brain 131(Pt 8):2071–2083PubMedPubMedCentralCrossRef

53.

McKay MS, Zakzanis KK (2010) The impact of treatment on HPA axis activity in unipolar major depression. J Psychiatr Res 44(3):183–192PubMedCrossRef

54.

Mehndiratta P, Sajatovic M (2013) Treatments for patients with comorbid epilepsy and depression: a systematic literature review. Epilepsy Behav 28(1):36–40PubMedCrossRef

55.

Miller WR, Seligman ME (1975) Depression and learned helplessness in man. J Abnorm Psychol 84(3):228–238PubMedCrossRef

56.

Mirescu C, Peters JD, Noiman L, Gould E (2006) Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids. Proc Natl Acad Sci Usa 103(50):19170–19175PubMedPubMedCentralCrossRef

57.

Mula M (2013) The interictal dysphoric disorder of epilepsy: a still open debate. Curr Neurol Neurosci Rep 13(6):355PubMedCrossRef

58.

Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM (2002) Neurobiology of depression. Neuron 34(1):13–25PubMedCrossRef

59.

Nichols DE, Nichols CD (2008) Serotonin receptors. Chem Rev 108(5):1614–1641PubMedCrossRef

60.

Nikisch G, Mathé AA, Czernik A et al (2005) Long-term citalopram administration reduces responsiveness of HPA axis in patients with major depression: relationship with S-citalopram concentrations in plasma and cerebrospinal fluid (CSF) and clinical response. Psychopharmacology (Berl) 181(4):751–760CrossRef

61.

Pauli E, Stefan H (2009) Emotional and affective disorders, anxiety and personality disorders in epilepsies. Nervenarzt 80(12):1440–1451PubMedCrossRef

62.

Pineda E, Shin D, Sankar R, Mazarati AM (2010) Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms. Epilepsia 51(Suppl 3):110–114PubMedPubMedCentralCrossRef

63.

Quiske A, Helmstaedter C, Lux S, Elger CE (2000) Depression in patients with temporal lobe epilepsy is related to mesial temporal sclerosis. Epilepsy Res 39(2):121–125PubMedCrossRef

64.

Richardson EJ, Griffith HR, Martin RC et al (2007) Structural and functional neuroimaging correlates of depression in temporal lobe epilepsy. Epilepsy Behav 10(2):242–249PubMedCrossRef

65.

Richardson-Jones JW, Craige CP, Guiard BP et al (2010) 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants. Neuron 65(1):40–52PubMedPubMedCentralCrossRef

66.

Salpekar JA, Mishra G, Hauptman JA (2015) Key issues in addressing the comorbidity of depression and pediatric epilepsy. Epilepsy Behav 46:12–18PubMedCrossRef

67.

Sapolsky RM (2000) Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry 57(10):925–935PubMedCrossRef

68.

Sayin U, Osting S, Hagen J, Rutecki P, Sutula T (2003) Spontaneous seizures and loss of axo-axonic and axo-somatic inhibition induced by repeated brief seizures in kindled rats. J Neurosci 23(7):2759–2768PubMed

69.

Sheline YI, Wang PW, Gado MH, Csernansky JG, Vannier MW (1996) Hippocampal atrophy in recurrent major depression. Proc Natl Acad Sci Usa 93(9):3908–3913PubMedPubMedCentralCrossRef

70.

Shemarova IV (2009) cAMP-dependent signal pathways in unicellular eukaryotes. Crit Rev Microbiol 35(1):23–42PubMedCrossRef

71.

Solomon DA, Keller MB, Leon AC et al (2000) Multiple recurrences of major depressive disorder. Am J Psychiatry 157(2):229–233PubMedCrossRef

72.

Stefan H, Schulze-Bonhage A, Pauli E et al (2004) Ictal pleasant sensations: cerebral localization and lateralization. Epilepsia 45(1):35–40PubMedCrossRef

73.

Stockmeier CA, Shapiro LA, Dilley GE, Kolli TN, Friedman L, Rajkowska G (1998) Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity. J Neurosci 18(18):7394–7401PubMed

74.

Stranahan AM, Khalil D, Gould E (2006) Social isolation delays the positive effects of running on adult neurogenesis. Nat Neurosci 9(4):526–533PubMedPubMedCentralCrossRef

75.

Taher TR, Salzberg M, Morris MJ, Rees S, O’Brien TJ (2005) Chronic low-dose corticosterone supplementation enhances acquired epileptogenesis in the rat amygdala kindling model of TLE. Neuropsychopharmacology 30(9):1610–1616PubMedCrossRef

76.

Tanapat P, Hastings NB, Rydel TA, Galea LA, Gould E (2001) Exposure to fox odor inhibits cell proliferation in the hippocampus of adult rats via an adrenal hormone-dependent mechanism. J Comp Neurol 437(4):496–504PubMedCrossRef

77.

van Tebartz EL, Krishnamoorthy ES, Schulze-Bonhage A et al (2011) Local area network inhibition: a model of a potentially important paraepileptic pathomechanism in neuropsychiatric disorders. Epilepsy Behav 22(2):231–239CrossRef

78.

Tellez-Zenteno JF, Patten SB, Jetté N, Williams J, Wiebe S (2007) Psychiatric comorbidity in epilepsy: a population-based analysis. Epilepsia 48(12):2336–2344PubMed

79.

Toczek MT, Carson RE, Lang L et al (2003) PET imaging of 5-HT1A receptor binding in patients with temporal lobe epilepsy. Neurology 60(5):749–756PubMedCrossRef

80.

Trindade-Filho EM, de Castro-Neto EF, de Carvalho AR et al (2008) Serotonin depletion effects on the pilocarpine model of epilepsy. Epilepsy Res 82(2–3):194–199PubMedCrossRef

81.

Vermoesen K, Massie A, Smolders I, Clinckers R (2012) The antidepressants citalopram and reboxetine reduce seizure frequency in rats with chronic epilepsy. Epilepsia 53(5):870–878PubMedCrossRef

82.

Vythilingam M, Vermetten E, Anderson GM et al (2004) Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment. Biol Psychiatry 56(2):101–112PubMedCrossRef

83.

Zhou J, Cao X, Mar AC et al (2014) Activation of postsynaptic 5-HT1A receptors improve stress adaptation. Psychopharmacology (Berl) 231(10):2067–2075CrossRef

84.

Zobel A, Wellmer J, Schulze-Rauschenbach S et al (2004) Impairment of inhibitory control of the hypothalamic pituitary adrenocortical system in epilepsy. Eur Arch Psychiatry Clin Neurosci 254(5):303–311PubMedCrossRef

85.

Zobel AW, Yassouridis A, Frieboes RM, Holsboer F (1999) Prediction of medium-term outcome by cortisol response to the combined dexamethasone-CRH test in patients with remitted depression. Am J Psychiatry 156(6):949–951PubMedCrossRef

Titel: Depression und Epilepsie
Zwei Krankheitsbilder mit gemeinsamen Ursachen?
verfasst von: Dr. M. Borgmann
Prof. Dr. M. Holtkamp
PD Dr. M. Adli
Prof. Dr. J. Behr
Publikationsdatum: 23.11.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Der Nervenarzt / Ausgabe 7/2016
Print ISSN: 0028-2804
Elektronische ISSN: 1433-0407
DOI: https://doi.org/10.1007/s00115-015-0026-4

Neu in den Fachgebieten Neurologie und Psychiatrie

23.04.2024 | Demenz | Nachrichten

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Depression und Epilepsie

Zwei Krankheitsbilder mit gemeinsamen Ursachen?

Zusammenfassung

Hintergrund

Ziel der Arbeit

Material und Methoden

Ergebnisse und Diskussion

Neu in den Fachgebieten Neurologie und Psychiatrie

Demenzkranke durch Antipsychotika vielfach gefährdet

Parkinson-Therapie im Wandel – aktuelle Leitlinie im Fokus

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Zusammenfassung

Hintergrund

Ziel der Arbeit

Material und Methoden

Ergebnisse und Diskussion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 7/2016

Schizophrene Psychosen mit affektdominanter Symptomatik

Somatische Morbidität bei psychisch Kranken

Überwindung der Therapieresistenz bei chronischer Depression

Chancen und Kontroversen von Depotantipsychotika in der Behandlung von Patienten mit Schizophrenie

Leitliniengerechte stationäre psychiatrisch-psychotherapeutische Behandlung der Zwangsstörung

Zwangsbehandlung psychisch Kranker im Maßregelvollzug: verfassungswidrig, aber …

Neu in den Fachgebieten Neurologie und Psychiatrie

Demenzkranke durch Antipsychotika vielfach gefährdet

Parkinson-Therapie im Wandel – aktuelle Leitlinie im Fokus

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein