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Erschienen in: Journal of Behavioral Medicine 6/2017

21.06.2017

Depressive symptoms in patients with obstructive sleep apnea: biological mechanistic pathways

verfasst von: Diana A. Chirinos, Indira Gurubhagavatula, Preston Broderick, Julio A. Chirinos, Karen Teff, Thomas Wadden, Greg Maislin, Hassam Saif, Jesse Chittams, Caitlin Cassidy, Alexandra L. Hanlon, Allan I. Pack

Erschienen in: Journal of Behavioral Medicine | Ausgabe 6/2017

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Abstract

This study examined the association between depressive symptoms, as well as depressive symptom dimensions, and three candidate biological pathways linking them to Obstructive sleep apnea (OSA): (1) inflammation; (2) circulating leptin; and (3) intermittent hypoxemia. Participants included 181 obese adults with moderate-to-severe OSA enrolled in the Cardiovascular Consequences of Sleep Apnea (COSA) trial. Depressive symptoms were measured using the Beck Depression Inventory-II (BDI-II). We assessed inflammation using C-reactive protein levels (CRP), circulating leptin by radioimmunoassay using a double antibody/PEG assay, and intermittent hypoxemia by the percentage of sleep time each patient had below 90% oxyhemoglobin saturation. We found no significant associations between BDI-II total or cognitive scores and CRP, leptin, or percentage of sleep time below 90% oxyhemoglobin saturation after controlling for relevant confounding factors. Somatic symptoms, however, were positively associated with percentage of sleep time below 90% saturation (β = 0.202, P = 0.032), but not with CRP or circulating leptin in adjusted models. Another significant predictor of depressive symptoms included sleep efficiency (βBDI Total = −0.230, P = 0.003; βcognitive = −0.173, P = 0.030 (βsomatic = -0.255, P = 0.001). In patients with moderate-to-severe OSA, intermittent hypoxia may play a role in somatic rather than cognitive or total depressive symptoms.
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Metadaten
Titel
Depressive symptoms in patients with obstructive sleep apnea: biological mechanistic pathways
verfasst von
Diana A. Chirinos
Indira Gurubhagavatula
Preston Broderick
Julio A. Chirinos
Karen Teff
Thomas Wadden
Greg Maislin
Hassam Saif
Jesse Chittams
Caitlin Cassidy
Alexandra L. Hanlon
Allan I. Pack
Publikationsdatum
21.06.2017
Verlag
Springer US
Erschienen in
Journal of Behavioral Medicine / Ausgabe 6/2017
Print ISSN: 0160-7715
Elektronische ISSN: 1573-3521
DOI
https://doi.org/10.1007/s10865-017-9869-4

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