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Gynäkologische Endokrinologie

Erschienen in:

01.05.2015 | Leitthema

Der frühe Embryo

Netzwerke autologer, maternaler und iatrogener Regulation

verfasst von: Prof. Dr. W. Würfel

Erschienen in: Gynäkologische Endokrinologie | Ausgabe 2/2015

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Zusammenfassung

Reparaturmechanismen früher Embryonen in vitro

In vitro kultivierte Embryonen bzw. Blastozysten zeigen eine hohe Aneuploidierate. Es liegen Belege vor, dass v. a. Mosaikbildungen durch Selbstreparaturmechanismen korrigiert werden können. Diese Mechanismen scheinen in erster Linie im Embryo selbst, also genomisch, angelegt zu sein. Darüber hinaus scheint es auch eine Beeinflussung durch externe Faktoren zu geben, v. a. Zytokine und Wachstumsfaktoren, die maternaler Herkunft sind und vermutlich auch noch nach der Implantation, also in der Schwangerschaft wirken.

Übertragbarkeit auf In-vivo-Bedingungen

Nahezu alle Erkenntnisse hierzu basieren auf der In-vitro-Kultur, deren Bedingungen aber nach wie vor nicht physiologisch sind. Deshalb können die in vitro gewonnenen Einsichten nur mit großem Vorbehalt auf die Verhältnisse in vivo übertragen werden.

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Titel: Der frühe Embryo
Netzwerke autologer, maternaler und iatrogener Regulation
verfasst von: Prof. Dr. W. Würfel
Publikationsdatum: 01.05.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Gynäkologische Endokrinologie / Ausgabe 2/2015
Print ISSN: 1610-2894
Elektronische ISSN: 1610-2908
DOI: https://doi.org/10.1007/s10304-015-0002-x

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Der frühe Embryo

Netzwerke autologer, maternaler und iatrogener Regulation

Zusammenfassung

Reparaturmechanismen früher Embryonen in vitro

Übertragbarkeit auf In-vivo-Bedingungen

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Zusammenfassung

Reparaturmechanismen früher Embryonen in vitro

Übertragbarkeit auf In-vivo-Bedingungen

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