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Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 9/2012

01.09.2012 | Cornea

Descemet's stripping endothelial keratoplasty (DSEK) for children with congenital hereditary endothelial dystrophy: surgical challenges and 1-year outcomes

verfasst von: Jatin N. Ashar, K. Madhavi Latha, Pravin K. Vaddavalli

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 9/2012

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Abstract

Purpose

To evaluate the outcomes of Descemet's stripping endothelial keratoplasty (DSEK) in patients with congenital hereditary endothelial dystrophy (CHED).

Methods

Retrospective, interventional case series of five eyes of five patients with congenital hereditary endothelial dystrophy (CHED) undergoing Descemet's stripping endothelial keratoplasty (DSEK) from June 2009 to June 2010 by a single surgeon. Patients were evaluated during the postoperative period for visual acuity, refraction, corneal clarity, lenticule status, and intraocular pressure. Anterior segment ocular coherence tomography (OCT) and confocal microscopy were performed when possible.

Results

Three male and two female children with an average age of 7.8 years (range 5–12 years) with CHED underwent DSEK. Surgery was uneventful in all patients and the lenticules stayed attached during the postoperative period. All the patients had 1-year follow-up. Corneal clarity improved in all the patients over the period of follow-up. Anterior segment OCT showed a gradual reduction in the thickness of the central corneal thickness and the graft over a period of time.

Conclusions

DSEK is a viable alternative to penetrating keratoplasty in patients with CHED with distinct advantages of reduced postoperative astigmatism and potential reduction of postoperative complications.
Literatur
1.
Zurück zum Zitat Lee WB, Jacobs DS, Musch DC, Kaufman SC, Reinhart WJ, Shtein RM (2009) Descemet’s stripping endothelial keratoplasty: safety and outcomes: a report by the American Academy of Ophthalmology. Ophthalmology 116:1818–1830 PubMedCrossRef Lee WB, Jacobs DS, Musch DC, Kaufman SC, Reinhart WJ, Shtein RM (2009) Descemet’s stripping endothelial keratoplasty: safety and outcomes: a report by the American Academy of Ophthalmology. Ophthalmology 116:1818–1830 PubMedCrossRef
2.
Zurück zum Zitat Kirkness CM, McCartney A, Rice NS, Garner A, Steele AD (1987) Congenital hereditary corneal edema of Maumenee: its clinical features, management, and pathology. Br J Ophthalmol 71:130–144 PubMedCrossRef Kirkness CM, McCartney A, Rice NS, Garner A, Steele AD (1987) Congenital hereditary corneal edema of Maumenee: its clinical features, management, and pathology. Br J Ophthalmol 71:130–144 PubMedCrossRef
3.
Zurück zum Zitat Kenyon KR, Antine B (1971) The pathogenesis of congenital hereditary endothelial dystrophy of the cornea. Am J Ophthalmol 72:787–795 PubMed Kenyon KR, Antine B (1971) The pathogenesis of congenital hereditary endothelial dystrophy of the cornea. Am J Ophthalmol 72:787–795 PubMed
4.
Zurück zum Zitat Pearce WG, Tripathi RC, Morgan GO (1969) Congenital endothelial corneal dystrophy: clinical, pathological and genetic study. Br J Ophthalmol 53:577–591 PubMedCrossRef Pearce WG, Tripathi RC, Morgan GO (1969) Congenital endothelial corneal dystrophy: clinical, pathological and genetic study. Br J Ophthalmol 53:577–591 PubMedCrossRef
5.
Zurück zum Zitat Judisch GF, Maumenee IH (1978) Clinical differentiation of recessive congenital hereditary endothelial dystrophy and dominant hereditary endothelial dystrophy. Am J Ophthalmol 85:606–612 PubMed Judisch GF, Maumenee IH (1978) Clinical differentiation of recessive congenital hereditary endothelial dystrophy and dominant hereditary endothelial dystrophy. Am J Ophthalmol 85:606–612 PubMed
6.
Zurück zum Zitat Vanathi M, Panda A, Vengayil S, Chaudhuri Z, Dada T (2009) Pediatric keratoplasty. Surv Ophthalmol 54:245–271 PubMedCrossRef Vanathi M, Panda A, Vengayil S, Chaudhuri Z, Dada T (2009) Pediatric keratoplasty. Surv Ophthalmol 54:245–271 PubMedCrossRef
7.
Zurück zum Zitat Sajjadi H, Javadi MA, Hemmati R, Mirdeghan A, Parvin M, Nassiri N (1995) Results of penetrating keratoplasty in CHED. Cornea 14:18–25 PubMedCrossRef Sajjadi H, Javadi MA, Hemmati R, Mirdeghan A, Parvin M, Nassiri N (1995) Results of penetrating keratoplasty in CHED. Cornea 14:18–25 PubMedCrossRef
8.
Zurück zum Zitat Al-Rajhi AA, Wagoner MD (1997) Penetrating keratoplasty in congenital hereditary endothelial dystrophy. Ophthalmology 104:956–961 PubMed Al-Rajhi AA, Wagoner MD (1997) Penetrating keratoplasty in congenital hereditary endothelial dystrophy. Ophthalmology 104:956–961 PubMed
9.
Zurück zum Zitat Schaumberg DA, Moyes AL, Gomes JA, Dana MR (1999) Corneal transplantation in young children with congenital hereditary endothelial dystrophy. Multicenter pediatric keratoplasty study. Am J Ophthalmol 127:373–378 PubMedCrossRef Schaumberg DA, Moyes AL, Gomes JA, Dana MR (1999) Corneal transplantation in young children with congenital hereditary endothelial dystrophy. Multicenter pediatric keratoplasty study. Am J Ophthalmol 127:373–378 PubMedCrossRef
10.
Zurück zum Zitat Javadi MA, Baradaran-Rafii AR, Zamani M, Karimian F, Zare M, Einollahi B, Jafarinasab MR, Yazdani S (2003) Penetrating keratoplasty in young children with congenital hereditary endothelial dystrophy. Cornea 22:420–423 PubMedCrossRef Javadi MA, Baradaran-Rafii AR, Zamani M, Karimian F, Zare M, Einollahi B, Jafarinasab MR, Yazdani S (2003) Penetrating keratoplasty in young children with congenital hereditary endothelial dystrophy. Cornea 22:420–423 PubMedCrossRef
11.
Zurück zum Zitat Jeng BH, Marcotty A, Traboulsi EI (2008) Descemet stripping automated endothelial keratoplasty in a 2-year-old child. J AAPOS 12:317–318 PubMedCrossRef Jeng BH, Marcotty A, Traboulsi EI (2008) Descemet stripping automated endothelial keratoplasty in a 2-year-old child. J AAPOS 12:317–318 PubMedCrossRef
12.
Zurück zum Zitat Fernandez MM, Buckley EG, Afshari NA (2008) Descemet stripping automated endothelial keratoplasty in a child. J AAPOS 12:314–316 PubMedCrossRef Fernandez MM, Buckley EG, Afshari NA (2008) Descemet stripping automated endothelial keratoplasty in a child. J AAPOS 12:314–316 PubMedCrossRef
13.
Zurück zum Zitat Ponchel C, Malecaze F, Arné JL, Fournié P (2009) Descemet stripping automated endothelial keratoplasty in a child with Descemet membrane breaks after forceps delivery. Cornea 28:338–341 PubMedCrossRef Ponchel C, Malecaze F, Arné JL, Fournié P (2009) Descemet stripping automated endothelial keratoplasty in a child with Descemet membrane breaks after forceps delivery. Cornea 28:338–341 PubMedCrossRef
14.
Zurück zum Zitat Pineda R, Jain V, Shome D, Hunter DC, Natarajan S (2010) Descemet's stripping endothelial keratoplasty: is it an option for congenital hereditary endothelial dystrophy? Int Ophthalmol 30:307–310 PubMedCrossRef Pineda R, Jain V, Shome D, Hunter DC, Natarajan S (2010) Descemet's stripping endothelial keratoplasty: is it an option for congenital hereditary endothelial dystrophy? Int Ophthalmol 30:307–310 PubMedCrossRef
15.
Zurück zum Zitat Inoue T, Oshima Y, Hori Y, Maeda N (2010) A chandelier-illuminated anterior chamber maintainer for use during Descemet stripping automated endothelial keratoplasty in patients with advanced bullous keratopathy. Cornea 29:917–920 PubMedCrossRef Inoue T, Oshima Y, Hori Y, Maeda N (2010) A chandelier-illuminated anterior chamber maintainer for use during Descemet stripping automated endothelial keratoplasty in patients with advanced bullous keratopathy. Cornea 29:917–920 PubMedCrossRef
16.
Zurück zum Zitat Inoue T, Oshima Y, Shima C, Hori Y, Maeda N, Tano Y (2008) Chandelier illumination to complete Descemet stripping through severe hazy cornea during Descemet stripping automated endothelial keratoplasty. J Cataract Refract Surg 34:892–896 PubMedCrossRef Inoue T, Oshima Y, Shima C, Hori Y, Maeda N, Tano Y (2008) Chandelier illumination to complete Descemet stripping through severe hazy cornea during Descemet stripping automated endothelial keratoplasty. J Cataract Refract Surg 34:892–896 PubMedCrossRef
17.
Zurück zum Zitat Busin M, Beltz J, Scorcia V (2011) Descemet-stripping automated endothelial keratoplasty for congenital hereditary endothelial dystrophy. Arch Ophthalmol 129:1140–1146 PubMedCrossRef Busin M, Beltz J, Scorcia V (2011) Descemet-stripping automated endothelial keratoplasty for congenital hereditary endothelial dystrophy. Arch Ophthalmol 129:1140–1146 PubMedCrossRef
18.
Zurück zum Zitat Kobayashi A, Yokogawa H, Sugiyama K (2007) Non-Descemet stripping endothelial keratoplasty for endothelial dysfunction secondary to argon laser iridotomy. Am J Ophthalmol 146:534–549 Kobayashi A, Yokogawa H, Sugiyama K (2007) Non-Descemet stripping endothelial keratoplasty for endothelial dysfunction secondary to argon laser iridotomy. Am J Ophthalmol 146:534–549
19.
Zurück zum Zitat Kobayashi A, Yokogawa H, Sugiyama K (2009) In vivo laser confocal microscopy after non-Descemet’s stripping automated endothelial keratoplasty. Ophthalmology 116:1306–1313 PubMedCrossRef Kobayashi A, Yokogawa H, Sugiyama K (2009) In vivo laser confocal microscopy after non-Descemet’s stripping automated endothelial keratoplasty. Ophthalmology 116:1306–1313 PubMedCrossRef
Metadaten
Titel
Descemet's stripping endothelial keratoplasty (DSEK) for children with congenital hereditary endothelial dystrophy: surgical challenges and 1-year outcomes
verfasst von
Jatin N. Ashar
K. Madhavi Latha
Pravin K. Vaddavalli
Publikationsdatum
01.09.2012
Verlag
Springer-Verlag
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 9/2012
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-012-2014-8