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01.12.2012 | Hypothesis | Ausgabe 1/2012 Open Access

Cardiovascular Ultrasound 1/2012

Detection of coronary microembolization by Doppler ultrasound in patients with stable angina pectoris during percutaneous coronary interventions under an adjunctive antithrombotic therapy with abciximab: design and rationale of the High Intensity Transient Signals ReoPro (HITS-RP) study

Zeitschrift:
Cardiovascular Ultrasound > Ausgabe 1/2012
Autoren:
Daniel Kretzschmar, Christian Jung, Sylvia Otto, Stephan Utschig, Michael Hartmann, Thomas Lehmann, Atilla Yilmaz, Tudor C Pörner, Hans R Figulla, Markus Ferrari
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1476-7120-10-21) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

DK designed the study protocol and drafted the manuscript. SO and AY designed the study protocol. SU and TCP participated in study design. TL performed statistical analysis. MF conceived of the study and helped to draft the manuscript. HRF and CJ conceived of the study. All authors reviewed the manuscript. HRF and MF are the scientific supervisors of the project. DK is the corresponding author. All authors read and approved the final version of the manuscript.

Abstract

Background

Embolization of atherosclerotic debris from the rupture of a vulnerable atherosclerotic plaque occurs iatrogenically during percutaneous coronary interventions (PCI) and can induce myocardial necrosis. These microembolizations are detected as high intensity transient signals (HITS) using intracoronary Doppler technology.

Presentation of the hypothesis

In the presented study we will test if abciximab (ReoPro®) infusion reduces high intensity transient signals in patients with stable angina pectoris undergoing PCI in comparison to standard therapy alone.

Testing the hypothesis

The High Intensity Transient Signals ReoPro® (HITS-RP) study will enroll 60 patients. It is a prospective, single center, randomized, double-blinded, controlled trial. The study is designed to compare the efficacy of intravenous abciximab administration for reduction of microembolization during elective PCI. Patients will be randomized in a 1:1 fashion to abciximab or placebo infusion. The primary end point of the HITS-RP-Study is the number of HITS during PCI measured by intracoronary Doppler wire. Secondary endpoints are bleeding complications, elevation of cardiac biomarkers or ECG changes after percutaneous coronary interventions, changes in coronary flow velocity reserve, hs-CRP elevation, any major adverse cardio-vascular event during one month follow-up.

Implications of the hypothesis

The HITS-RP-Study addresses important questions regarding the efficacy of intravenous abciximab administration in reducing microembolization and periprocedural complications in stable angina pectoris patients undergoing PCI.
Zusatzmaterial
Authors’ original file for figure 1
12947_2012_422_MOESM1_ESM.pdf
Literatur
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