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Erschienen in: European Radiology 4/2017

10.08.2016 | Chest

Detection of pulmonary fat embolism with dual-energy CT: an experimental study in rabbits

verfasst von: Chun Xiang Tang, Chang Sheng Zhou, Yan E. Zhao, U. Joseph Schoepf, Stefanie Mangold, B. Devon Ball, Zong Hong Han, Li Qi, Long Jiang Zhang, Guang Ming Lu

Erschienen in: European Radiology | Ausgabe 4/2017

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Abstract

Objectives

To evaluate the use of dual-energy CT imaging of the lung perfused blood volume (PBV) for the detection of pulmonary fat embolism (PFE).

Methods

Dual-energy CT was performed in 24 rabbits before and 1 hour, 1 day, 4 days and 7 days after artificial induction of PFE via the right ear vein. CT pulmonary angiography (CTPA) and lung PBV images were evaluated by two radiologists, who recorded the presence, number, and location of PFE on a per-lobe basis. Sensitivity, specificity, and accuracy of CTPA and lung PBV for detecting PFE were calculated using histopathological evaluation as the reference standard.

Results

A total of 144 lung lobes in 24 rabbits were evaluated and 70 fat emboli were detected on histopathological analysis. The overall sensitivity, specificity and accuracy were 25.4 %, 98.6 %, and 62.5 % for CTPA, and 82.6 %, 76.0 %, and 79.2 % for lung PBV. Higher sensitivity (p < 0.001) and accuracy (p < 0.01), but lower specificity (p < 0.001), were found for lung PBV compared with CTPA. Dual-energy CT can detect PFE earlier than CTPA (all p < 0.01).

Conclusion

Dual-energy CT provided higher sensitivity and accuracy in the detection of PFE as well as earlier detection compared with conventional CTPA in this animal model study.

Key points

Fat embolism occurs commonly in patients with traumatic bone injury.
Dual-energy CT improves diagnostic performance for pulmonary fat embolism detection.
Dual-energy CT can detect pulmonary fat embolism earlier than CTPA.
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Metadaten
Titel
Detection of pulmonary fat embolism with dual-energy CT: an experimental study in rabbits
verfasst von
Chun Xiang Tang
Chang Sheng Zhou
Yan E. Zhao
U. Joseph Schoepf
Stefanie Mangold
B. Devon Ball
Zong Hong Han
Li Qi
Long Jiang Zhang
Guang Ming Lu
Publikationsdatum
10.08.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 4/2017
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-016-4512-2

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