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Journal of NeuroVirology

Erschienen in:

05.08.2019

Determinants of cognitive health in Indonesian HIV patients beginning antiretroviral therapy

verfasst von: Riwanti Estiasari, Ibnu Aryanto, Silvia Lee, Setia Pramana, Samsuridjal Djauzi, Patricia Price

Erschienen in: Journal of NeuroVirology | Ausgabe 1/2020

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Abstract

Cognitive impairment has been described in people living with HIV and stable on antiretroviral therapy (ART), but has not been monitored in young adults beginning ART with a high burden of cytomegalovirus. We recruited 80 subjects beginning ART with < 200 CD4 T cells/μL in Jakarta, Indonesia. Cognitive function (Z-scores) began low but improved on ART, stabilizing after 6 months with improvements in all domains except memory function. The burden of cytomegalovirus persisting on ART (assessed via antibody levels) correlated inversely with Z-scores (notably memory function) at baseline. In linear mixed models, improvements in Z-scores were influenced by age, education, and CD4 T cell counts.

Andrade ASA, Deutsch R, Celano S et al (2013) Relationships among neurocognitive status, medication adherence measured by pharmacy refill records, and virologic suppression in HIV-infected persons. JAIDS 62:282–292PubMed

Barber T, Bansi L, Pozniak A, Asboe D, Nelson M, Moyle G, Davies N, Margetts A, Ratcliffe D, Catalan J, Boffito M, Gazzard B (2017) Low levels of neurocognitive impairment detected in screening HIV-infected men who have sex with men: the MSM Neurocog Study. Int J STD AIDS 28:715–722CrossRef

Becker BW, Thames AD, Woo E, Castellon SA, Hinkin CH (2011) Longitudinal change in cognitive function and medication adherence in HIV-infected adults. AIDS Behav 15:1888–1894CrossRef

Brunt SJ, Lee S, D’Orsogna L, Bundell C, Burrows S, Price P (2014) The use of humoral responses as a marker of CMV burden in HIV patients on ART requires consideration of T-cell recovery and persistent B-cell activation. Dis Markers 2014:947432CrossRef

Brunt SJ, Cysique LA, Lee S, Burrows S, Brew BJ, Price P (2016) Do Cytomegalovirus antibody levels associate with age-related syndromes in HIV patients stable on antiretroviral therapy? AIDS Res Hum Retrovir 32:567–572CrossRef

Clifford DB, Vaida F, Kao Y-T, Franklin DR, Letendre SL, Collier AC, Marra CM, Gelman BB, McArthur JC, Morgello S, Simpson DM, Grant I, Heaton RK, For the CHARTER Group (2015) Absence of neurocognitive effect of hepatitis C infection in HIV-coinfected people. Neurology. 84:241–250CrossRef

Das Gupta J, Satishchandra P, Gopukumar K et al (2007) Neuropsychological deficits in human immunodeficiency virus type 1 clade C-seropositive adults from South India. J Neuro-Oncol 13:195–202

Dickerson F, Stallings C, Origoni A, Katsafanas E, Schweinfurth LAB, Savage CLG, Yolken R (2014) Association between Cytomegalovirus antibody levels and cognitive functioning in non-elderly adults. PLoS One 9(5):e95510CrossRef

Durier N, Ananworanich J, Apornpong T, Ubolyam S, Kerr SJ, Mahanontharit A, Ferradini L, Ruxrungtham K, Avihingsanon A (2013) Cytomegalovirus viremia in Thai HIV-infected patients on antiretroviral therapy: prevalence and associated mortality. Clin Infect Dis 57:147–155CrossRef

Edwar L, Karim B, Wijaya IP, Ariyanto I, Tanudjaja SA, Estiasari R, Sitompul R, Price P (2019) Factors affecting the health of retinal vessels in human immunodeficiency virus patients beginning anti-retroviral therapy. AIDS Res Hum Retrovir 35:529–535CrossRef

Ellis RJ, Badiee J, Vaida F et al (2011) CD4 nadir is a predictor of HIV neurocognitive impairment in the era of combination antiretroviral therapy. AIDS. 25(14):10CrossRef

Estiasari R, Imran D, Lastri DN, Prawirohardjo P, Price P (2015) Cognitive impairment among Indonesia HIV naïve patients. Neurology Asia 20:155–160

Gunstad J, Paul RH, Brickman AM, Cohen RA, Arns M, Roe D, Lawrence JJ, Gordon E (2006) Patterns of cognitive performance in middle-aged and older adults: a cluster analytic examination. J Geriatr Psychiatry Neurol 19:59–64CrossRef

Heaton RK, Clifford DB, Franklin DR, Woods SP, Ake C, Vaida F, Ellis RJ, Letendre SL, Marcotte TD, Atkinson JH, Rivera-Mindt M, Vigil OR, Taylor MJ, Collier AC, Marra CM, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Abramson I, Gamst A, Fennema-Notestine C, Jernigan TL, Wong J, Grant I, For the CHARTER Group (2010) HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy CHARTER Study. Neurology. 75:2087–2096CrossRef

Hodowanec A, Hanson B, Leurgans S, Barnes L, Lurain N, Adeyemi O (2016) Cytomegalovirus (CMV) immunoglobulin G levels are associated with neurocognitive dysfunction among adults over age 50 [Abstract]. Open Forum Infect Dis 3(suppl 1)

Karim B, Wijaya IP, Rahmaniyah R, Ariyanto I, Waters S, Estiasari R, Price P (2017) Factors affecting affect cardiovascular health in Indonesian HIV patients beginning ART. AIDS Res Ther 14:52CrossRef

Letendre S, Bharti A, Perez-Valero I, CNS HIV AntiRetroviral Therapy Effects Research (CHARTER) Group et al (2018) Higher anti-cytomegalovirus immunoglobulin G concentrations are associated with worse neurocognitive performance during suppressive antiretroviral therapy. Clin Infect Dis 67(5):770–777CrossRef

Luz Correa B, Ornaghi AP, Cerutti Muller G, Engroff P, Pestana Lopes R, Gomes da Silva Filho I, Bosch JA, Bonorino C, Bauer ME (2014) The inverted CD4:CD8 ratio is associated with cytomegalovirus, poor cognitive and functional states in older adults. Neuroimmunomod. 21:206–212CrossRef

McDonnell J, Haddow L, Daskalapulou M et al (2014) Minimal cognitive impairment in UK HIV-positive men who have sex with men: effect of case definitions and comparison with the general population and HIV negative men. JAIDS. 67:120–127PubMed

Ministry of Health Republic of Indonesia. (2017). Report on the development of HIV AIDS and STDs 2017. DitJen P2P. [Internet]. http://siha.depkes.go.id/portal/files_upload/Laporan_HIV_AIDS_TW_4_Tahun_2017__1_.pdf. Accessed 20 Jan 2019

Molenberghs G, Verbeke G (2000) Models for discrete longitudinal data. Springer, Berlin. https://doi.org/10.1007/0-387-28980-1 CrossRef

Sacktor N, Nakasujja N, Okonkwo O, Skolasky RL, Robertson K, Musisi S,Katabira E. Longitudinal neuropsychological test performance among HIVseropositive individuals in Uganda. J Neurovirol. 201319(1):48–56

Teruya LC, Ortiz KZ, Minett TSC (2009) Performance of normal adults on Rey Auditory Learning Test: a pilot study. Arq Neuropsiquiatr 67:224–228CrossRef

Vivithanaporn P, Maingat F, Lin L-T, Na H, Richardson CD, Agrawal B, Cohen ÉA, Jhamandas JH, Power C (2010) Hepatitis C virus core protein induces neuroimmune activation and potentiates HIV-1 neurotoxicity. PLoS One 5(9):e12856CrossRef

Wulandari EAT, Saraswati H, Adawiyah R, Djauzi S, Wahyuningsih R, Price P (2017) Immunological and epidemiological factors affecting candidiasis in HIV patients beginning antiretroviral therapy in an Asian clinic. Arch Oral Biol 82:86–91CrossRef

Zayyad Z, Spudich S (2015) Neuropathogenesis of HIV: from initial neuroinvasion to HIV-associated neurocognitive disorder (HAND). Curr HIV/AIDS Rep 12:16–24CrossRef

Titel: Determinants of cognitive health in Indonesian HIV patients beginning antiretroviral therapy
verfasst von: Riwanti Estiasari
Ibnu Aryanto
Silvia Lee
Setia Pramana
Samsuridjal Djauzi
Patricia Price
Publikationsdatum: 05.08.2019
Verlag: Springer International Publishing
Erschienen in: Journal of NeuroVirology / Ausgabe 1/2020
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-019-00787-2

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