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Rheumatology International

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07.11.2017 | Observational Research

Determinants of mortality in systemic sclerosis: a focused review

verfasst von: Dilli Ram Poudel, Divya Jayakumar, Abhijeet Danve, Shiv Tej Sehra, Chris T. Derk

Erschienen in: Rheumatology International | Ausgabe 10/2018

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Abstract

Scleroderma (systemic sclerosis) is an autoimmune rheumatic disorder that is characterized by fibrosis, vascular dysfunction, and autoantibody production that involves most visceral organs. It is characterized by a high morbidity and mortality rate, mainly due to disease-related complications. Epidemiological data describing mortality and survival in this population have been based on both population and observational studies. Multiple clinical and non-clinical factors have been found to predict higher likelihood of death among thepatients. Here, we do an extensive review of the available literature, utilizing the PubMed database, to describe scleroderma and non-scleroderma related determinants of mortality in this population. We found that even though the mortality among the general population has declined, scleroderma continues to carry a very high morbidity and mortality rate, however we have made some slow progress in improving the mortality among scleroderma patients over the last few decades.

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Titel: Determinants of mortality in systemic sclerosis: a focused review
verfasst von: Dilli Ram Poudel
Divya Jayakumar
Abhijeet Danve
Shiv Tej Sehra
Chris T. Derk
Publikationsdatum: 07.11.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Rheumatology International / Ausgabe 10/2018
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-017-3826-y

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Weitere Artikel der Ausgabe 10/2018

Development and validation of SCAISS, a tool for semi-automated quantification of sacroilitis by magnetic resonance in spondyloarthritis

Platelet to lymphocyte ratio is associated with the current activity of ANCA-associated vasculitis at diagnosis: a retrospective monocentric study

Ultrasound of sacroiliac joints in spondyloarthritis: a systematic review

The subjective components of the Disease Activity Score 28-joints (DAS28) in rheumatoid arthritis patients and coexisting fibromyalgia

Musculoskeletal ultrasound for predicting remission in patients with rheumatoid arthritis: results from a 1-year prospective study

Concomitant use of intravenous methylprednisolone to increase retention rate of abatacept in rheumatoid arthritis

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