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01.12.2014 | Original Article | Ausgabe 12/2014

Supportive Care in Cancer 12/2014

Determinants of quality of life during induction therapy in pediatric acute lymphoblastic leukemia

Zeitschrift:
Supportive Care in Cancer > Ausgabe 12/2014
Autoren:
Raphaële R. L. van Litsenburg, Jaap Huisman, Rob Pieters, Chris Verhaak, Gertjan J. L. Kaspers, Reinoud J. B. J. Gemke
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s00520-014-2349-2) contains supplementary material, which is available to authorized users.

Abstract

Purpose

Improvement in survival of pediatric acute lymphoblastic leukemia (ALL) has increased the attention to quality of life (QoL) . QoL is impaired during maintenance treatment, but little is known about QoL during induction therapy. Identification of patients with poor QoL during induction will provide opportunities for early interventions, and may subsequently improve future QoL. This national multi-center study aimed to assess QoL and its determinants during ALL induction treatment.

Methods

Proxy reports of the Child Health Questionnaire (CHQ) and the PedsQL cancer version were collected. Child, treatment, and parental characteristics were analyzed as potential determinants in a multiple regression model.

Results

One hundred thirty parents of children participated (response rate 82 %), median child age was 5.7 years and 48 % were female. QoL, as measured with the CHQ, was significantly lower than the norm, the effect sizes were large, and the differences were clinically relevant. Physical QoL was more often affected than psychosocial QoL. Regression models could be constructed for 4/ 10 CHQ scales and 6/ 8 PedsQL cancer scales, accounting for 7 to 36 % of the variance in scores. Impaired QoL was most often associated with older children, girls, and time since diagnosis. Also, father respondents seem to have a lower QoL perception compared to mother respondents although this needs to be confirmed in future research.

Conclusions

Specific counseling for subsets of patients with a higher risk of low QoL during the early phases of therapy is warranted.

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Zusatzmaterial
ESM 1 (DOC 44 kb)
520_2014_2349_MOESM1_ESM.doc
ESM 2 (DOC 38 kb)
520_2014_2349_MOESM2_ESM.doc
Literatur
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