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23.04.2019 | Original Paper

Determination of perillaldehyde in perilla herbs using relative molar sensitivity to single-reference diphenyl sulfone

verfasst von: Naoko Masumoto, Yuzo Nishizaki, Takeshi Maruyama, Yasushi Igarashi, Kaori Nakajima, Taichi Yamazaki, Miho Kuroe, Masahiko Numata, Toshihide Ihara, Naoki Sugimoto, Kyoko Sato

Erschienen in: Journal of Natural Medicines | Ausgabe 3/2019

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Abstract

Perillaldehyde (PRL) is one of the essential oil components derived from perilla plants (Perilla frutescens Britton) and is a characteristic compound of the traditional medicine “perilla herb (蘇葉)” listed in the The Japanese Pharmacopoeia, 17th edition (JP17). HPLC using an analytical standard of PRL has been used to quantitatively determine the PRL content in perilla herb. However, PRL reagents have been reported to decompose easily. In this study, we utilized an alternative quantitative method using on a single reference with relative molar sensitivity (RMS) based on the results of experiments performed in two laboratories. It was possible to calculate the exact RMS using an offline combination of ¹H-quantitative NMR spectroscopy (¹H-qNMR) and an HPLC/photodiode array (PDA) detector (or an HPLC/variable-wavelength detector [VWD]). Using the RMS of PRL to the single-reference compound diphenyl sulfone (DFS), which is an inexpensive and stable compound, the PRL content in the perilla herb could be determined using HPLC/PDA or HPLC/VWD without the need for the analytical standard of PRL. There was no significant difference between the PRL contents of perilla herb determined using the method employing the single-reference DFS with RMS and using the JP17 assay, the calibration curve of which was generated using the analytical standard of PRL with adjusted purity measured by ¹H-qNMR. These results demonstrate that our proposed method using a single reference with RMS is suitable for quantitative assays of perilla herb and can be an alternative method for the current assay method defined in the JP17.

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Titel: Determination of perillaldehyde in perilla herbs using relative molar sensitivity to single-reference diphenyl sulfone
verfasst von: Naoko Masumoto
Yuzo Nishizaki
Takeshi Maruyama
Yasushi Igarashi
Kaori Nakajima
Taichi Yamazaki
Miho Kuroe
Masahiko Numata
Toshihide Ihara
Naoki Sugimoto
Kyoko Sato
Publikationsdatum: 23.04.2019
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 3/2019
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-019-01306-7

Springer Medizin

Abstract

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