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Erschienen in:

18.09.2018

Development and content validity of a hemodialysis symptom patient-reported outcome measure

verfasst von: Jennifer E. Flythe, Adeline Dorough, Julia H. Narendra, Rebecca L. Wingard, Lorien S. Dalrymple, Darren A. DeWalt

Erschienen in: Quality of Life Research | Ausgabe 1/2019

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Abstract

Purpose

To describe the process and preliminary qualitative development of a new symptom-based patient-reported outcome measure (PROM) intended to assess hemodialysis treatment-related physical symptoms.

Methods

Experienced interviewers conducted concept elicitation and cognitive debriefing interviews with individuals receiving in-center hemodialysis in the United States. Concept elicitation interviews involved eliciting spontaneous reports of symptom experiences and probing to further explore and confirm concepts. We used patient-reported concepts to generate a preliminary symptom PROM. We conducted 3 rounds of cognitive debriefing interviews to evaluate symptom relevance, item interpretability, and draft item structure. We iteratively refined the measure based on cognitive interview findings.

Results

Forty-two adults receiving in-center hemodialysis participated in the concept elicitation interviews. A total of 12 symptoms were reported by > 10% of interviewees. We developed a 13-item initial draft instrument for testing in 3 rounds of cognitive interviews with an additional 52 hemodialysis patients. Participant responses and feedback during cognitive interviews led to changes in symptom descriptions, division of the single item “nausea/vomiting” into 2 distinct items, removal of daily activity interference items, addition of instructions, and clarification about the recall period, among other changes.

Conclusions

Symptom Monitoring on Renal Replacement Therapy-Hemodialysis (SMaRRT-HD™) is a 14-item PROM intended for use in hemodialysis patents. SMaRRT-HD™ uses a single treatment recall period and a 5-point Likert scale to assess symptom severity. Qualitative interview data provide evidence of its content validity. SMaRRT-HD™ is undergoing additional testing to assess measurement properties and inform measure scoring.

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Titel: Development and content validity of a hemodialysis symptom patient-reported outcome measure
verfasst von: Jennifer E. Flythe
Adeline Dorough
Julia H. Narendra
Rebecca L. Wingard
Lorien S. Dalrymple
Darren A. DeWalt
Publikationsdatum: 18.09.2018
Verlag: Springer International Publishing
Erschienen in: Quality of Life Research / Ausgabe 1/2019
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-018-2000-7

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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