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21.03.2018 | Review

Development and endoscopic appearance of colorectal tumors are characterized by the expression profiles of miRNAs

verfasst von: Yoshihito Nakagawa, Yukihiro Akao, Tomomitsu Tahara, Hiromi Yamashita, Mitsuo Nagasaka, Tomoyuki Shibata, Naoki Ohmiya

Erschienen in: Medical Molecular Morphology | Ausgabe 2/2018

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Abstract

Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We previously reported to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. In this report, we focused on colorectal adenoma (tubular or tubulovillous adenoma), or tubular early carcinoma or type 2 adenocarcinoma, familial adenomatous polyposis (FAP), ulcerative colitis-associated tumor (UCAT), and sessile serrated adenoma/polyp (SSA/P). We tried to clarify the relationship between the expression of the miRNAs and the colorectal tumor development. The expression levels of miR-143, -145, and -34a were reduced in most of the polypoid and FAP tumors compared with those in the flat elevated, UCAT, SSA/P ones. In type 2 adenocarcinomas, the expression profile of these miRNAs was similar to those of the polypoid and FAP tumors. The expression levels of miR-7 and -21 were up-regulated in non-granular type of laterally spreading tumor, UCAT, and SSA/P compared with those in polypoid and FAP tumors. These findings indicated that the expression of onco-related miRNAs was closely associated with the development and endoscopic appearance of colorectal tumors.

Lee RC, Feinbaum RL. Ambros V (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75:843–854CrossRefPubMed

Ambros V (2004) The functions of animal microRNAs. Nature 431:350–355CrossRefPubMed

Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15–20CrossRefPubMed

Croce CM, Calin GA (2005) miRNAs, cancer, and stem cell division. Cell 122:6–7CrossRefPubMed

Gregory RI, Shiekhattar R (2005) MicroRNA biogenesis and cancer. Cancer Res 65:3509–3512CrossRefPubMed

Akao Y, Nakagawa Y, Hirata I, Iio A, Itoh T, Kojima K, Nakashima R, Kitade Y, Naoe T (2010) Role of anti-oncomirs miR-143 and -145 in human colorectal tumors. Cancer Gene Ther 17:398–408CrossRefPubMed

Nakagawa Y, Akao Y, Taniguchi K, Kamatani A, Tahara T, Kamano T, Nakano N, Komura N, Ikuno H, Ohmori T, Jodai Y, Miyata M, Nagasaka M, Shibata T, Ohmiya N, Hirata I (2015) Relationship between expression of onco-related miRNAs and the endoscopic appearance of colorectal tumors. Int J Mol Sci 16:1526–1543CrossRefPubMedPubMedCentral

Akao Y, Noguchi S, Iio A, Kojima K, Takagi T, Naoe T (2011) Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells. Cancer Lett 300:197–204CrossRefPubMed

Tuchiya N, Nakagama H (2010) MicroRNA, SND1, and alterations in translational regulation in colon carcinogenesis. Mutat Res 693:94–100CrossRef

10.

Schetter AJ, Leung SY, Sohn JJ, Zanetti KA, Bowman ED, Yanaihara N, Yuen ST, Chan TL, Kwong DL, Au GK, Liu CG, Calin GA, Croce CM, Harris CC (2008) MicroRNA expression profile associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA 299:425–436PubMedPubMedCentral

11.

Xiong B, Cheng Y, Ma L, Zhang C (2013) MiR-21 regulates biological behavior through the PTEN/PI-3K/Akt signaling pathway in human colorectal cancer cells. Int J Oncol 42:219–228CrossRefPubMed

12.

Lu Z, Liu M, Stribinskis V, Klinge CM, Ramos KS, Colburn NH, Li Y (2008) MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene 27:4373–4379CrossRefPubMed

13.

Ahmed FE, Ahmed NC, Vos PW, Bonnerup C, Atkins JN, Casey M, Nuovo GJ, Naziri W, Wiley JE, Mota H, Allison RR (2013) Diagnostic microRNA markers to screen for sporadic human colon cancer in stool: I. Proof of principle. Cancer Genom Proteom 10:93–113

14.

Zhang N, Li X, Wu CW, Dong Y, Cai M, Mok MT, Wang H, Chen J, Ng SS, Chen M, Sung JJ, Yu J (2013) MicroRNA-7 is a novel inhibitor of YY1 contributing to colorectal tumorigenesis. Oncogene 32:5078–5088CrossRefPubMed

15.

Michael MZ, O’Connor SM, van Holst Pellekaan NG, Young GP, James RJ (2003) Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res 1:882–891PubMed

16.

Minamoto T, Sawaguchi K, Mai M, Yamashita N, Sugimura T, Esumi H (1994) Infrequent K-Ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas. Cancer Res 54:2841–2844PubMed

17.

Fujimori T, Satonaka K, Yamamura-Idei Y, Nagasako K, Maeda S (1994) Non-involvement of Ras mutations in flat colorectal adenomas and carcinomas. Int J Cancer 57:51–55CrossRefPubMed

18.

Shirai H, Ueno E, Osaki M, Tatebe S, Ito H, Kaibara N (1995) Expression of growth factor and their receptors in human early colorectal carcinomas: immunohistochemical study. Anticancer Res 15:2889–2894PubMed

19.

Sada M, Mitomi H, Igarashi M, Katsumata T, Saigenji K, Okayasu I (1999) Cell kinetics, p53 and Bcl-2 expression, and c-Ki-Ras mutations in flat-elevated tubulovillous adenomas and adenocarcinomas of the colorectum: comparison with polypoid lesions. Scand J Gastroenterol 34:798–807CrossRefPubMed

20.

Kudo S, Kashida H, Nakajima T, Tamura S, Nakajo K (1997) Endoscopic diagnosis and treatment of early colorectal cancer. World J Surg 21:694–701CrossRefPubMed

21.

Tamura S, Onishi S (2004) Laterally spreading colon cancer. N Engl J Med 351:e24CrossRefPubMed

22.

Uraoka T, Saito Y, Matsuda T, Ikehara H, Gotoda T, Saito D, Fujii T (2006) Endoscopic indication for endoscopic mucosal resection of laterally spreading tumors in the colorectum. Gut 55:1592–1597CrossRefPubMedPubMedCentral

23.

Scarpa M, Castagliuolo I, Castoro C, Pozza A, Scarpa M, Kotsafti A, Angriman I (2014) Inflammatory colonic carcinogenesis: a review on pathogenesis and immunosurveillance mechanisms in ulcerative colitis. World J Gastroenterol 20:6774–6785CrossRefPubMedPubMedCentral

24.

Saraggi D, Fassan M, Mescoli C, Scarpa M, Valeri N, Michielan A, D’Incá R, Rugge M (2016) The molecular landscape of colitis-associated carcinogenesis. Dig Liver Dis 49:326–330CrossRefPubMed

25.

Kobayashi K, Tomita H, Shimizu M, Tanaka T, Suzui N, Miyazaki T, Hara A (2017) p53 expression as a diagnostic biomarker in ulcerative colitis-associated cancer. Int J Mol Sci 18:E1284CrossRefPubMed

26.

Fujita K, Yamamoto H, Matsumoto T, Hirahashi M, Gushima M, Kishimoto J, Nishiyama K, Taguchi T, Yao T, Oda Y (2011) Sessile serrated adenoma with early neoplastic progression: a clinicopathologic and molecular study. Am J Surg Pathol 35:295–304CrossRefPubMed

27.

Bettington M, Walker N, Rosty C, Brown I, Clouston A, McKeone D, Pearson SA, Leggett B, Whitehall V (2017) Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma. Gut 66:97–106CrossRefPubMed

28.

Japanese Society for Cancer of the Colon and Rectum (2013) In Japanese Classification of Colorectal Carcinoma, 8th edn. Kanehara Shuppan, Tokyo

29.

Akao Y, Nakagawa Y, Kitade Y, Kinoshita T, Naoe T (2007) Down-regulation of microRNAs-143 and -145 in B-cell malignancies. Cancer Sci 98:1914–1920CrossRefPubMed

30.

Nakagawa Y, Iinuma M, Naoe T, Nozawa Y, Akao Y (2007) Characterized mechanism of α-mangostin-induced cell death: Caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells. Bioorg Med Chem 15:5620–5628CrossRefPubMed

31.

Takagi T, Iio A, Nakagawa Y, Naoe T, Tanigawa N, Akao Y (2009) Decreased expression of microRNA-143 and -145 in human gastric cancers. Oncology 77:12–21CrossRefPubMed

32.

Iio A, Nakagawa Y, Hirata I, Naoe T, Akao Y (2010) Identification of non-coding RNAs embracing microRNA-143/145 cluster. Mol Cancer 9:136–142CrossRefPubMedPubMedCentral

33.

Chen Z, Zeng H, Guo Y, Liu P, Pan H, Deng A, Hu J (2010) miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-myc. J Exp Clin Cancer Res 29:151CrossRefPubMedPubMedCentral

34.

English JM, Pearson G, Baer R, Cobb MH (1998) Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases. J Biol Chem 73:3854–3860CrossRef

35.

Rothberg PG (1987) The role of the oncogene c-myc in sporadic large bowel cancer and familial polyposis coli. Semin Surg Oncol 3:152–158CrossRefPubMed

36.

Hashimoto K, Nakagawa Y, Morikawa H, Niki M, Egashira Y, Hirata I, Katsu K, Akao Y (2001) Co-overexpression of DEAD box protein rck/p54 and c-myc protein in human colorectal adenomas and the relevance of their expression in cultured cell lines. Carcinogenesis 22:1965–1970CrossRefPubMed

37.

Akao Y, Kumasaki M, Shinohara H, Sugito N, Kuranaga Y, Tsujino T, Yoshikawa Y, Kitade Y (2018) Impairment of K-Ras signaling networks and increased efficacy of EGFR inhibitors by a novel synthetic miR-143. Cancer Sci (in press)

38.

Su J, Liang H, Yao W, Wang N, Zhang S, Yan X, Feng H, Pang W, Wang Y, Wang X, Fu Z, Liu Y, Zhao C, Zhang J, Zhang CY, Zen K, Chen X, Wang Y (2014) MiR-143 and MiR-145 regulate IGF1R to suppress cell proliferation in colorectal cancer. PLoS One 9:e114420CrossRefPubMedPubMedCentral

39.

Siemens H, Jackstadt R, Kaller M, Hermeking H (2013) Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness. Oncotarget 4:1399–1415CrossRefPubMedPubMedCentral

40.

Nagano Y, Toiyama Y, Okugawa Y, Imaoka H, Fujikawa H, Yasuda H, Yoshiyama S, Hiro J, Kobayashi M, Ohi M, Araki T, Inoue Y, Mohri Y, Kusunoki M (2016) MicroRNA-7 Is associated with malignant potential and poor prognosis in human colorectal cancer. Anticancer Res 36:6521–6526CrossRefPubMed

41.

Vicinus B, Rubie C, Stegmaier N, Frick VO, Kölsch K, Kauffels A, Ghadjar P, Wagner M, Glanemann M (2013) miR-21 and its target gene CCL20 are both highly overexpressed in the microenvironment of colorectal tumors: significance of their regulation. Oncol Rep 30:1285–1292CrossRefPubMed

42.

Kinzier KW, Vogelstein B (1996) Lessons from hereditary colorectal cancer. Cell 87:159–170CrossRef

43.

Senda T, Shimomura A, Iizuka-Koga A (2005) Adenomatous polyposis coli (Apc) tumor suppressor gene as a multifunctional gene. Anat Sci Int 80:121–131CrossRefPubMed

44.

Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61:759–767CrossRefPubMed

45.

Muto T, Nagawa H, Watanabe T, Masaki T, Sawada T (1997) Colorectal carcinogenesis: Historical review. Dis Colon Rectum 40:S80–S85CrossRefPubMed

46.

Mukawa K, Fujii S, Takeda J, Kitajima K, Tominaga K, Chibana Y, Fujita M, Ichikawa K, Tomita S, Ono Y, Imura J, Kawamata H, Chiba T, Hiraishi H, Terano A, Fujimori T (2005) Analysis of K-Ras mutations and expression of cyclooxygenase-2 and gastrin protein in laterally spreading tumors. J Gastroenterol Hepatol 20:1584–1590CrossRefPubMed

47.

Hiraoka S, Kato J, Tatsukawa M, Harada K, Fujita H, Morikawa T, Shiraha H, Shiratori Y (2006) Laterally spreading type of colorectal adenoma exhibits a unique methylation phenotype and K-Ras mutations. Gastroenterology 131:379–389CrossRefPubMed

48.

Teixeira CR, Tanaka S, Haruma K, Yoshihara M, Sumii K, Kajiyama G, Shimamoto F (1996) Flat-elevated colorectal neoplasms exhibit a high malignant potential. Oncology 53:89–93CrossRefPubMed

49.

Zauber AG, Winawer SJ, O’Brien MJ, Lansdorp VI, Ballegooijen MV, Hankey BF, Shi W, Bond JH, Schapiro M, Joel F, Panish JF, Stewart ET, Waye JD (2012) Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths. N Engl J Med 366:687–696CrossRefPubMedPubMedCentral

50.

Nagel R, le Sage C, Diosdado B, van der Waal M, Oude Vrielink JA, Bolijn A, Meijer GA, Agami R (2008) Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. Cancer Res 68:5795–5802CrossRefPubMed

51.

Liao WT, Ye YP, Zhang NJ, Li TT, Wang SY, Cui YM, Qi L, Wu P, Jiao HL, Xie YJ, Zhang C, Wang JX, Ding YQ (2014) MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2. J Pathol 232:415–427CrossRefPubMed

52.

Chai J, Wang S, Han D, Dong W, Xie C, Guo H (2015) MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase. Tumour Biol 36:1313–1321CrossRefPubMed

Titel: Development and endoscopic appearance of colorectal tumors are characterized by the expression profiles of miRNAs
verfasst von: Yoshihito Nakagawa
Yukihiro Akao
Tomomitsu Tahara
Hiromi Yamashita
Mitsuo Nagasaka
Tomoyuki Shibata
Naoki Ohmiya
Publikationsdatum: 21.03.2018
Verlag: Springer Japan
Erschienen in: Medical Molecular Morphology / Ausgabe 2/2018
Print ISSN: 1860-1480
Elektronische ISSN: 1860-1499
DOI: https://doi.org/10.1007/s00795-018-0186-y

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Development and endoscopic appearance of colorectal tumors are characterized by the expression profiles of miRNAs

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