Erschienen in:
20.02.2016 | Introduction to Invited Review Articles
Development and future directions of antiangiogenic therapy in hepatocellular carcinoma
verfasst von:
Akinobu Taketomi
Erschienen in:
International Journal of Clinical Oncology
|
Ausgabe 2/2016
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Excerpt
Angiogenesis is a promising therapeutic target in treatments aimed at inhibiting tumor growth. Since the study published by Folkman in 1971 that demonstrated that tumor growth is angiogenesis-dependent [
1], research has focused on identifying new therapeutic agents that can inhibit angiogenesis. In 2004, bevacizumab was developed as a potent inhibitor of vascular endothelial growth factor (VEGF), and this agent demonstrated modest antitumor activity when combined with chemotherapy. Currently, inhibition of angiogenesis has become a standard treatment option for several tumor types, including colorectal cancer, glioblastoma and ovarian cancer. …