Background
Methods
Development of the QLICD-PT
General principles and steps of developing QLICD-PT
Modifying QLICD-GM
Domains/facets | Number of items | Range scores | Scoring method | |
---|---|---|---|---|
Raw score | Standardized score | |||
Physical domain (PHD) | 9 | 9–45 | BPF + IND + EAD | (RS-9) × 100/36 |
Basic physiologic functions (BPF) | 4 | 4–20 | GPH1 + GPH2 + GPH3 + GPH4 | (RS-4) × 100/16 |
Independence (IND) | 3 | 3–15 | GPH6 + GPH7 + GPH8 | (RS-3) × 100/12 |
Energy and discomfort (EAD) | 2 | 2–10 | GPH5 + GPH9 | (RS-2) × 100/8 |
Psychological domain (PSD) | 11 | 11–55 | COG+EMO + WIP | (RS-11) × 100/44 |
Cognition (COG) | 2 | 2–10 | GPS1 + GPS2+ | (RS-2) × 100/8 |
Emotion (EMO) | 7 | 7–35 | GPS3 + GPS4 + GPS5 + GPS6GPS7+ GPS8 + GPS9 | (RS-7) × 100/28 |
Will and personality (WIP) | 2 | 2–10 | GPS10+ GPS11 | (RS-2) × 100/8 |
Social domain (SOD) | 8 | 8–40 | INC + SSS + SOR | (RS-8) × 100/32 |
Interpersonal communication (INC) | 3 | 3–15 | GSO1 + GSO2 + GSO3 | (RS-3) × 100/12 |
Social support and security (SSS) | 3 | 3–15 | GSO4 + GSO5 + GSO6 | (RS-3) × 100/12 |
Social role (SOR) | 2 | 2–10 | GSO7 + GSO8 | (RS-2) × 100/8 |
Sub-total (QLICD-GM) | 28 | 28–140 | PHD + PSD + SOD | (RS-28) × 100/112 |
TB Specific domain (SPD) | 12 | 12–60 | RES + COS + DSE + SPM | (RS-12) × 100/48 |
Respiratory symptom (RES) | 6 | 6–30 | PT1 + PT2 + PT3 + PT4 + PT5 + PT6 | (RS-6) × 100/24 |
Constitutional symptom (COS) | 3 | 3–15 | PT7 + PT8 + PT12 | (RS-3) × 100/12 |
Drug side-effects (DSE) | 1 | 1–5 | PT9 | (RS-1) × 100/4 |
Special mention (SPM) | 2 | 2–10 | PT10 + PT11 | (RS-2) × 100/8 |
Total (TOT) | 40 | 40–200 | PHD + PSD + SOD+SPD | (RS-40) × 100/160 |
Creating pulmonary TB specific module
Validation of the QLICD-PT
Data collection and scoring
Analytic steps and indicators used to measure the validity
Construct validity
Content validity
Internal consistency (reliability)
Responsiveness
Results
Socio-demographic characteristics of the sample
Validity
Item | Physical domain | PHD | Psychological domain | PSD | Social domain | SOD | Specific domain | SPD | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BPF | IND | EAD | COG | EMO | WIP | INC | SSS | SOR | RES | COS | DSE | SPM | |||||
GPH1 |
0.69
| 0.33 | 0.33 |
0.57
| 0.31 | 0.30 | 0.25 | 0.34 | 0.24 | 0.17 | 0.36 | 0.31 | 0.26 | 0.12 | 0.21 | 0.12 | 0.47 |
GPH2 |
0.68
| 0.25 | 0.23 |
0.49
| 0.30 | 0.20 | 0.24 | 0.27 | 0.31 | 0.16 | 0.24 | 0.30 | 0.21 | 0.09 | 0.06 | 0.07 | 0.19 |
GPH3 |
0.56
| 0.21 | 0.38 |
0.47
| 0.38 | 0.28 | 0.25 | 0.34 | 0.18 | 0.19 | 0.23 | 0.25 | 0.16 | 0.07 | 0.17 | 0.21 | 0.21 |
GPH4 |
0.63
| 0.25 | 0.14 |
0.44
| 0.26 | 0.23 | 0.25 | 0.28 | 0.38 | 0.21 | 0.21 | 0.33 | 0.13 | 0.12 | 0.05 | 0.08 | 0.15 |
GPH5 | 0.35 | 0.36 |
0.81
|
0.60
| 0.41 | 0.40 | 0.27 | 0.44 | 0.20 | 0.35 | 0.36 | 0.38 | 0.35 | 0.15 | 0.19 | 0.21 | 0.36 |
GPH6 | 0.37 |
0.89
| 0.28 |
0.71
| 0.45 | 0.27 | 0.35 | 0.38 | 0.45 | 0.40 | 0.36 | 0.50 | 0.17 | 0.21 | 0.25 | 0.03 | 0.21 |
GPH7 | 0.36 |
0.85
| 0.47 |
0.75
| 0.55 | 0.27 | 0.32 | 0.39 | 0.29 | 0.40 | 0.44 | 0.47 | 0.28 | 0.28 | 0.27 | 0.07 | 0.32 |
GPH8 | 0.32 |
0.90
| 0.36 |
0.72
| 0.45 | 0.30 | 0.40 | 0.40 | 0.40 | 0.37 | 0.39 | 0.48 | 0.12 | 0.17 | 0.24 | 0.02 | 0.17 |
GPH9 | 0.37 | 0.35 |
0.83
|
0.61
| 0.44 | 0.52 | 0.30 | 0.53 | 0.17 | 0.26 | 0.36 | 0.32 | 0.38 | 0.16 | 0.22 | 0.19 | 0.38 |
GPS1 | 0.43 | 0.57 | 0.35 | 0.59 |
0.82
| 0.31 | 0.49 |
0.53
| 0.38 | 0.41 | 0.42 | 0.50 | 0.27 | 0.32 | 0.29 | 0.10 | 0.34 |
GPS2 | 0.40 | 0.37 | 0.51 | 0.53 |
0.84
| 0.48 | 0.40 |
0.63
| 0.25 | 0.29 | 0.43 | 0.40 | 0.26 | 0.12 | 0.25 | 0.22 | 0.30 |
GPS3 | 0.25 | 0.13 | 0.16 | 0.22 | 0.16 |
0.23
| 0.16 |
0.24
| 0.27 | 0.10 | 0.14 | 0.21 | 0.00 | −0.03 | −0.06 | −0.07 | −0.03 |
GPS4 | 0.17 | 0.06 | 0.32 | 0.21 | 0.26 |
0.57
| 0.35 |
0.54
| 0.02 | 0.11 | 0.22 | 0.14 | 0.19 | 0.13 | 0.25 | 0.26 | 0.27 |
GPS5 | 0.28 | 0.31 | 0.36 | 0.40 | 0.41 |
0.63
| 0.36 |
0.62
| 0.15 | 0.31 | 0.38 | 0.34 | 0.24 | 0.18 | 0.25 | 0.27 | 0.33 |
GPS6 | 0.24 | 0.19 | 0.37 | 0.32 | 0.25 |
0.69
| 0.30 |
0.61
| 0.10 | 0.14 | 0.33 | 0.23 | 0.32 | 0.22 | 0.21 | 0.44 | 0.43 |
GPS7 | 0.28 | 0.26 | 0.45 | 0.40 | 0.36 |
0.76
| 0.50 |
0.73
| 0.27 | 0.33 | 0.39 | 0.41 | 0.29 | 0.23 | 0.27 | 0.26 | 0.37 |
GPS8 | 0.34 | 0.26 | 0.45 | 0.43 | 0.40 |
0.78
| 0.54 |
0.76
| 0.34 | 0.24 | 0.37 | 0.39 | 0.34 | 0.25 | 0.31 | 0.28 | 0.42 |
GPS9 | 0.22 | 0.18 | 0.35 | 0.30 | 0.25 |
0.71
| 0.46 |
0.65
| 0.26 | 0.27 | 0.41 | 0.39 | 0.23 | 0.16 | 0.27 | 0.22 | 0.30 |
GPS10 | 0.27 | 0.41 | 0.22 | 0.40 | 0.39 | 0.33 |
0.75
|
0.49
| 0.48 | 0.47 | 0.37 | 0.55 | 0.19 | 0.15 | 0.23 | 0.11 | 0.23 |
GPS11 | 0.31 | 0.19 | 0.29 | 0.32 | 0.41 | 0.58 |
0.74
|
0.67
| 0.13 | 0.26 | 0.38 | 0.31 | 0.26 | 0.08 | 0.21 | 0.14 | 0.27 |
GSO1 | 0.34 | 0.43 | 0.22 | 0.44 | 0.44 | 0.30 | 0.43 | 0.41 |
0.78
| 0.46 | 0.45 |
0.70
| 0.17 | 0.21 | 0.27 | 0.29 | 0.29 |
GSO2 | 0.33 | 0.24 | 0.15 | 0.31 | 0.19 | 0.18 | 0.20 | 0.22 |
0.76
| 0.25 | 0.25 |
0.52
| 0.08 | 0.15 | 0.09 | −0.05 | 0.09 |
GSO3 | 0.31 | 0.24 | 0.13 | 0.30 | 0.16 | 0.21 | 0.27 | 0.25 |
0.76
| 0.30 | 0.19 |
0.52
| 0.07 | 0.12 | 0.11 | 0.08 | 0.12 |
GSO4 | 0.18 | 0.38 | 0.19 | 0.33 | 0.28 | 0.17 | 0.39 | 0.27 | 0.42 |
0.66
| 0.31 |
0.59
| 0.07 | 0.08 | 0.09 | −0.06 | 0.07 |
GSO5 | 0.22 | 0.31 | 0.20 | 0.32 | 0.26 | 0.18 | 0.39 | 0.27 | 0.44 |
0.78
| 0.37 |
0.67
| 0.10 | 0.04 | 0.06 | 0.13 | 0.12 |
GSO6 | 0.20 | 0.25 | 0.35 | 0.33 | 0.33 | 0.33 | 0.25 | 0.37 | 0.13 |
0.62
| 0.39 |
0.48
| 0.23 | 0.22 | 0.20 | 0.28 | 0.32 |
GSO7 | 0.32 | 0.25 | 0.36 | 0.38 | 0.36 | 0.52 | 0.39 | 0.53 | 0.22 | 0.33 |
0.81
|
0.55
| 0.24 | 0.25 | 0.32 | 0.39 | 0.38 |
GSO8 | 0.30 | 0.48 | 0.28 | 0.47 | 0.43 | 0.25 | 0.38 | 0.36 | 0.45 | 0.50 |
0.72
|
0.68
| 0.12 | 0.17 | 0.21 | −0.05 | 0.14 |
PT1 | 0.17 | 0.10 | 0.26 | 0.21 | 0.16 | 0.20 | 0.13 | 0.20 | 0.06 | 0.06 | 0.14 | 0.10 |
0.72
| 0.26 | 0.10 | 0.17 |
0.61
|
PT2 | 0.20 | 0.07 | 0.23 | 0.20 | 0.16 | 0.14 | 0.12 | 0.17 | 0.02 | 0.04 | 0.11 | 0.07 |
0.73
| 0.28 | 0.21 | 0.13 |
0.63
|
PT3 | 0.28 | 0.21 | 0.44 | 0.37 | 0.35 | 0.36 | 0.32 | 0.40 | 0.15 | 0.16 | 0.20 | 0.21 |
0.82
| 0.22 | 0.44 | 0.35 |
0.77
|
PT4 | 0.23 | 0.08 | 0.37 | 0.26 | 0.23 | 0.34 | 0.30 | 0.35 | 0.12 | 0.18 | 0.19 | 0.20 |
0.75
| 0.28 | 0.29 | 0.25 |
0.69
|
PT5 | 0.06 | 0.19 | 0.16 | 0.18 | 0.16 | 0.22 | 0.09 | 0.21 | 0.17 | 0.17 | 0.13 | 0.19 |
0.54
| 0.24 | 0.26 | 0.08 |
0.48
|
PT6 | 0.31 | 0.37 | 0.43 | 0.46 | 0.32 | 0.35 | 0.32 | 0.39 | 0.15 | 0.30 | 0.28 | 0.30 |
0.68
| 0.22 | 0.34 | 0.20 |
0.62
|
PT7 | 0.27 | 0.38 | 0.34 | 0.42 | 0.35 | 0.35 | 0.23 | 0.38 | 0.30 | 0.28 | 0.42 | 0.41 | 0.39 |
0.80
| 0.33 | 0.25 |
0.60
|
PT8 | 0.15 | 0.23 | 0.24 | 0.26 | 0.27 | 0.27 | 0.17 | 0.29 | 0.19 | 0.19 | 0.27 | 0.27 | 0.39 |
0.85
| 0.29 | 0.19 |
0.59
|
PT9 | 0.20 | 0.29 | 0.25 | 0.32 | 0.32 | 0.35 | 0.30 | 0.39 | 0.23 | 0.18 | 0.35 | 0.31 | 0.38 | 0.27 |
1.00
|
0.26
|
0.54
|
PT10 | 0.11 | 0.06 | 0.21 | 0.15 | 0.16 | 0.30 | 0.06 | 0.26 | 0.12 | 0.13 | 0.17 | 0.17 | 0.28 | 0.24 | 0.30 |
0.87
|
0.55
|
PT11 | 0.24 | 0.02 | 0.21 | 0.18 | 0.18 | 0.37 | 0.23 | 0.35 | 0.18 | 0.22 | 0.26 | 0.27 | 0.20 | 0.09 | 0.14 | 0.84 |
0.42
|
PT12 | −0.20 | − 0.21 | − 0.34 | −0.30 | −0.22 | − 0.21 | − 0.17 | −0.24 | −0.14 | −0.21 | −0.26 | −0.25 | −0.21 |
0.15
| −0.19 | − 0.12 |
− 0.16
|
Items | Principal components and its variance contribution (%) | ||||||
---|---|---|---|---|---|---|---|
P1 (10.99) | P2 (10.28) | P3 (9.50) | P4 (8.78) | P5 (7.63) | P6 (7.39) | P7 (7.23) | |
GPH1 | 0.12 | 0.10 | 0.22 | 0.14 | −0.03 | 0.66 | 0.07 |
GPH2 | 0.13 | −0.02 | 0.08 | 0.05 | 0.19 | 0.75 | 0.04 |
GPH3 | 0.06 | 0.13 | 0.09 | 0.02 | 0.12 | −0.03 | 0.74 |
GPH4 | 0.01 | 0.20 | 0.05 | 0.24 | 0.37 | 0.52 | −0.13 |
GPH5 | 0.15 | 0.09 | 0.30 | 0.13 | 0.08 | 0.06 | 0.64 |
GPH6 | 0.25 | 0.07 | 0.08 | 0.86 | 0.22 | 0.14 | 0.03 |
GPH7 | 0.33 | −0.02 | 0.22 | 0.61 | − 0.19 | 0.24 | 0.30 |
GPH8 | 0.25 | 0.06 | 0.11 | 0.85 | 0.16 | 0.07 | 0.13 |
GPH9 | 0.05 | 0.39 | 0.22 | 0.18 | −0.10 | 0.33 | 0.38 |
GPS1 | 0.56 | 0.08 | 0.14 | 0.33 | −0.16 | 0.35 | 0.24 |
GPS2 | 0.04 | 0.39 | 0.14 | 0.26 | 0.04 | 0.18 | 0.58 |
GPS3 | 0.10 | 0.04 | −0.23 | −0.06 | 0.39 | 0.44 | 0.21 |
GPS4 | 0.04 | 0.74 | 0.00 | −0.04 | − 0.21 | 0.10 | 0.13 |
GPS5 | 0.05 | 0.23 | 0.50 | 0.27 | 0.01 | −0.03 | 0.28 |
GPS6 | −0.06 | 0.37 | 0.61 | 0.13 | −0.07 | 0.14 | −0.04 |
GPS7 | 0.17 | 0.62 | 0.46 | 0.05 | 0.10 | 0.07 | 0.07 |
GPS8 | 0.15 | 0.60 | 0.45 | 0.03 | 0.24 | 0.06 | 0.14 |
GPS9 | 0.11 | 0.55 | 0.47 | 0.05 | 0.27 | −0.11 | 0.03 |
GPS10 | 0.74 | 0.05 | 0.24 | 0.11 | 0.07 | 0.17 | −0.05 |
GPS11 | 0.04 | 0.77 | 0.12 | 0.09 | 0.10 | 0.04 | 0.18 |
GSO1 | 0.65 | 0.01 | 0.33 | 0.16 | 0.10 | 0.22 | −0.02 |
GSO2 | 0.19 | 0.01 | −0.05 | 0.10 | 0.77 | 0.17 | 0.17 |
GSO3 | 0.23 | 0.03 | 0.05 | 0.12 | 0.81 | 0.12 | 0.00 |
GSO4 | 0.65 | 0.18 | −0.24 | 0.25 | 0.29 | −0.16 | 0.15 |
GSO5 | 0.71 | 0.02 | 0.08 | 0.05 | 0.26 | −0.05 | 0.08 |
GSO6 | 0.17 | 0.01 | 0.58 | 0.05 | −0.18 | 0.12 | 0.25 |
GSO7 | 0.12 | 0.18 | 0.68 | 0.01 | 0.04 | 0.13 | 0.22 |
GSO8 | 0.59 | 0.19 | −0.11 | 0.31 | 0.08 | 0.16 | 0.19 |
Items | Principal components and its variance contribution (%) | |||
---|---|---|---|---|
P1 (21.54) | P2 (15.97) | P3 (15.13) | P4 (13.05) | |
PT1 | 0.18 | 0.16 | 0.90 | 0.07 |
PT2 | 0.22 | 0.22 | 0.87 | 0.02 |
PT3 | 0.74 | 0.11 | 0.31 | 0.33 |
PT4 | 0.72 | 0.13 | 0.21 | 0.20 |
PT5 | 0.64 | 0.05 | 0.13 | −0.18 |
PT6 | 0.77 | 0.08 | 0.10 | 0.10 |
PT7 | 0.21 | 0.83 | 0.11 | 0.10 |
PT8 | 0.21 | 0.81 | 0.15 | −0.02 |
PT9 | 0.55 | 0.39 | −0.15 | 0.18 |
PT10 | 0.21 | 0.15 | 0.02 | 0.76 |
PT11 | 0.02 | 0.08 | 0.06 | 0.85 |
PT12 | 0.04 | −0.53 | −0.16 | −0.17 |
QLICD-PT | SF-36 | |||||||
---|---|---|---|---|---|---|---|---|
Physical function | Role-physical | Body pain | General health | Vitality | Social function | Role-emotional | Mental health | |
Physical | 0.56 | 0.43 | 0.49 | 0.42 | 0.54 | 0.51 | 0.37 | 0.36 |
Psychological | 0.29 | 0.28 | 0.46 | 0.34 | 0.46 | 0.49 | 0.30 | 0.50 |
Social | 0.35 | 0.32 | 0.40 | 0.41 | 0.44 | 0.47 | 0.26 | 0.44 |
Domains/facets | Internal consistency Coefficient α | Floor effects (%) | Ceiling effects (%) |
---|---|---|---|
Physical domain (PHD) | 0.78 | 0.0 | 0.5 |
Basic physiologic functions (BPF) | 0.50 | 0.0 | 1.0 |
Independence (IND) | 0.83 | 0.5 | 48.5 |
Energy and discomfort (EAD) | 0.51 | 1.0 | 3.0 |
Psychological domain (PSD) | 0.81 | 0.0 | 0.5 |
Cognition (COG) | 0.55 | 0.0 | 13.0 |
Emotion (EMO) | 0.74 | 0.0 | 0.5 |
Will and personality (WIP) | 0.20 | 0.0 | 17.5 |
Social domain (SOD) | 0.72 | 0.0 | 2.0 |
Interpersonal communication (INC) | 0.61 | 0.0 | 11.5 |
Social support and security (SSS) | 0.42 | 0.0 | 4.5 |
Social role (SOR) | 0.30 | 1.5 | 14.5 |
Sub-total (QLICD-GM) | 0.89 | 0.0 | 0.0 |
Specific domain (SPD) | 0.78 | 0.0 | 0.0 |
Respiratory symptom (RES) | 0.80 | 0.5 | 1.5 |
Constitutional symptom (COS) | 0.26 | 0.0 | 1.0 |
Drug side-effects (DSE) | – | 2.0 | 53.0 |
Special mention (SPM) | 0.62 | 5.5 | 5.5 |
Total (TOT) | 0.90 | 0.0 | 0.0 |
Reliability and responsiveness
Domains/facets | Before treatment | After 2 months treatment | After 6 months treatment | SRM (2 months) | SRM (6 months) | Variance analysis P | Post-hoc P | ||
---|---|---|---|---|---|---|---|---|---|
Before vs.2 months | Before vs.6 months | 2 vs.6 months | |||||||
Physical domain | 68.79 ± 13.40 | 72.31 ± 13.20 | 74.23 ± 13.13 | 0.32 | 0.39 | < 0.001 | 0.001 | < 0.001 | 0.067 |
Basic physiologic functions | 58.78 ± 13.61 | 62.78 ± 14.67 | 64.12 ± 15.08 | 0.23 | 0.33 | < 0.001 | 0.002 | < 0.001 | 0.283 |
Independence | 85.55 ± 21.62 | 88.19 ± 19.26 | 89.72 ± 19.69 | 0.18 | 0.23 | 0.011 | 0.059 | 0.003 | 0.273 |
Energy and discomfort | 63.69 ± 20.29 | 67.56 ± 20.74 | 71.20 ± 19.20 | 0.19 | 0.32 | < 0.001 | 0.033 | < 0.001 | 0.046 |
Psychological domain | 67.95 ± 14.52 | 69.97 ± 15.02 | 70.66 ± 15.00 | 0.16 | 0.17 | 0.039 | 0.067 | 0.014 | 0.529 |
Cognition | 71.12 ± 19.90 | 72.55 ± 19.72 | 75.32 ± 19.39 | 0.08 | 0.20 | 0.023 | 0.356 | 0.007 | 0.073 |
Emotion | 65.69 ± 15.83 | 68.04 ± 15.86 | 67.86 ± 15.56 | 0.16 | 0.13 | 0.102 | |||
Will and personality | 72.71 ± 18.76 | 74.13 ± 20.45 | 75.79 ± 19.84 | 0.08 | 0.14 | 0.157 | |||
Social domain | 72.37 ± 14.83 | 73.80 ± 16.50 | 75.85 ± 14.96 | 0.12 | 0.24 | 0.006 | 0.192 | 0.002 | 0.060 |
Interpersonal communication | 73.21 ± 16.62 | 74.10 ± 17.64 | 76.11 ± 16.40 | 0.06 | 0.16 | 0.097 | |||
Social support and security | 72.31 ± 17.14 | 74.00 ± 18.46 | 76.11 ± 17.57 | 0.12 | 0.22 | 0.017 | 0.203 | 0.004 | 0.112 |
Social role | 71.20 ± 22.11 | 73.02 ± 23.03 | 75.08 ± 19.63 | 0.10 | 0.18 | 0.050 | |||
Sub-total (QLICD-GM) | 69.48 ± 12.55 | 71.81 ± 13.16 | 73.29 ± 12.51 | 0.23 | 0.31 | < 0.001 | 0.010 | < 0.001 | 0.102 |
Specific domain | 66.07 ± 15.14 | 74.96 ± 14.28 | 77.76 ± 14.66 | 0.65 | 0.72 | < 0.001 | < 0.001 | < 0.001 | 0.015 |
Respiratory symptom | 64.69 ± 20.31 | 78.48 ± 18.19 | 81.75 ± 19.52 | 0.76 | 0.83 | < 0.001 | < 0.001 | < 0.001 | 0.027 |
Constitutional symptom | 70.25 ± 16.62 | 73.77 ± 13.66 | 74.74 ± 13.13 | 0.21 | 0.24 | 0.002 | 0.008 | 0.001 | 0.475 |
Drug side-effects | 81.65 ± 24.83 | 80.85 ± 25.58 | 87.18 ± 21.07 | 0.03 | 0.20 | 0.007 | 0.714 | 0.011 | 0.004 |
Special mention | 56.17 ± 26.61 | 63.21 ± 24.89 | 65.59 ± 24.30 | 0.28 | 0.35 | < 0.001 | < 0.001 | < 0.001 | 0.209 |
Total (TOT) | 68.46 ± 11.74 | 72.76 ± 11.58 | 74.63 ± 11.12 | 0.47 | 0.56 | < 0.001 | < 0.001 | < 0.001 | 0.019 |