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Erschienen in: Annals of Nuclear Medicine 12/2022

13.10.2022 | Original Article

Development of a novel small-animal myocardial phantom can evaluate the image quality of dual-isotope simultaneous acquisition (DISA)

verfasst von: Takayuki Shibutani, Masahisa Onoguchi, Takayuki Kanno, Hiroshi Wakabayashi, Tomo Hiromasa, Seigo Kinuya

Erschienen in: Annals of Nuclear Medicine | Ausgabe 12/2022

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Abstract

Background

Myocardial phantom studies are widely used as a tool to accurately assess the physical phenomenon of dual-isotope simultaneous acquisition (DISA) in the small-animal fields. However, the previous phantom did not reproduce the structures of rats or mice. The aim of this study was to develop a novel myocardial phantom simulating the structure of a small animal that can be evaluated using the image quality of DISA.

Methods

A novel small-animal myocardial phantom that simulated a rat was constructed by the myocardium, liver, lung, spine, and torso. Normal and inferior wall defect myocardial phantoms were filled with 99mTc or 18F solution to simulate single-isotope acquisition (SIA) and DISA. Phantom and small-animal images with no scatter correction (nonSC) and scatter correction (SC) were created.

Results

The 99mTc DISA with SC showed a low %CV compared to that with nonSC. Although the 99mTc DISA with nonSC had lower cavity contrast than that of 99mTc SIA with nonSC, the cavity contrast of SC had similar values between SIA and DISA. The minimum %uptake of 99mTc SIA with nonSC was a lower value compared to that of 99mTc DISA with nonSC. The 99mTc DISA was equivalent to the minimum %uptake of 99mTc SIA by SC.

Conclusion

We have developed a novel myocardial phantom for the rat model to evaluate the image quality for reproducing the physical phenomenon associated with radiation attenuation and scattering. Furthermore, we could demonstrate the usefulness of the novel small-animal myocardial phantom by image quality evaluation of DISA with 99mTc and 18F compared to SIA.
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Metadaten
Titel
Development of a novel small-animal myocardial phantom can evaluate the image quality of dual-isotope simultaneous acquisition (DISA)
verfasst von
Takayuki Shibutani
Masahisa Onoguchi
Takayuki Kanno
Hiroshi Wakabayashi
Tomo Hiromasa
Seigo Kinuya
Publikationsdatum
13.10.2022
Verlag
Springer Nature Singapore
Erschienen in
Annals of Nuclear Medicine / Ausgabe 12/2022
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-022-01791-z

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