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Annals of Nuclear Medicine
Erschienen in:

13.10.2022 | Original Article

Development of a novel small-animal myocardial phantom can evaluate the image quality of dual-isotope simultaneous acquisition (DISA)

verfasst von: Takayuki Shibutani, Masahisa Onoguchi, Takayuki Kanno, Hiroshi Wakabayashi, Tomo Hiromasa, Seigo Kinuya

Erschienen in: Annals of Nuclear Medicine | Ausgabe 12/2022

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Abstract

Background

Myocardial phantom studies are widely used as a tool to accurately assess the physical phenomenon of dual-isotope simultaneous acquisition (DISA) in the small-animal fields. However, the previous phantom did not reproduce the structures of rats or mice. The aim of this study was to develop a novel myocardial phantom simulating the structure of a small animal that can be evaluated using the image quality of DISA.

Methods

A novel small-animal myocardial phantom that simulated a rat was constructed by the myocardium, liver, lung, spine, and torso. Normal and inferior wall defect myocardial phantoms were filled with 99mTc or 18F solution to simulate single-isotope acquisition (SIA) and DISA. Phantom and small-animal images with no scatter correction (nonSC) and scatter correction (SC) were created.

Results

The 99mTc DISA with SC showed a low %CV compared to that with nonSC. Although the 99mTc DISA with nonSC had lower cavity contrast than that of 99mTc SIA with nonSC, the cavity contrast of SC had similar values between SIA and DISA. The minimum %uptake of 99mTc SIA with nonSC was a lower value compared to that of 99mTc DISA with nonSC. The 99mTc DISA was equivalent to the minimum %uptake of 99mTc SIA by SC.

Conclusion

We have developed a novel myocardial phantom for the rat model to evaluate the image quality for reproducing the physical phenomenon associated with radiation attenuation and scattering. Furthermore, we could demonstrate the usefulness of the novel small-animal myocardial phantom by image quality evaluation of DISA with 99mTc and 18F compared to SIA.
Literatur
1.
Hendrikx G, Vöö S, Bauwens M, Post MJ, Mottaghy FM. SPECT and PET imaging of angiogenesis and arteriogenesis in pre-clinical models of myocardial ischemia and peripheral vascular disease. Eur J Nucl Med Mol Imaging. 2016;43(13):2433–47.CrossRefPubMedPubMedCentral
2.
Berman DS, Maddahi J, Tamarappoo BK, Czernin J, Taillefer R, Udelson JE, et al. Phase II safety and clinical comparison with single-photon emission computed tomography myocardial perfusion imaging for detection of coronary artery disease: flurpiridaz F 18 positron emission tomography. J Am Coll Cardiol. 2013;61(4):469–77.CrossRefPubMed
3.
Yu M, Nekolla SG, Schwaiger M, Robinson SP. The next generation of cardiac positron emission tomography imaging agents: discovery of flurpiridaz F-18 for detection of coronary disease. Semin Nucl Med. 2011;41(4):305–13.CrossRefPubMed
4.
Dobrucki LW, Sinusas AJ. Molecular cardiovascular imaging. Curr Cardiol Rep. 2005;7(2):130–5.CrossRefPubMed
5.
Golestani R, Wu C, Tio RA, Zeebregts CJ, Petrov AD, Beekman FJ, et al. Small-animal SPECT and SPECT/CT: application in cardiovascular research. Eur J Nucl Med Mol Imaging. 2010;37(9):1766–77.CrossRefPubMedPubMedCentral
6.
Wakabayashi H, Taki J, Inaki A, Hiromasa T, Yamase T, Akatani N, et al. Prognostic value of early evaluation of left ventricular dyssynchrony after myocardial infarction. Mol Imaging Biol. 2019;21(4):654–9.CrossRefPubMed
7.
Wakabayashi H, Taki J, Inaki A, Hiromasa T, Okuda K, Shibutani T, et al. Quantification of myocardial perfusion defect size in rats: comparison between quantitative perfusion SPECT and autoradiography. Mol Imaging Biol. 2018;20(4):544–50.CrossRefPubMed
8.
Onoguchi M, Takayama T, Tonami N, Kyogoku S, Naoi Y, Irimoto M, et al. Comparison of 99mTc-tetrofosmin uptakes on planar images with those in excised rats organs. Ann Nucl Med. 2001;15(1):33–40.CrossRefPubMed
9.
Han JH, Lim SY, Lee MS, Lee WW. Sodium [18F] fluoride PET/CT in myocardial infarction. Mol Imaging Biol. 2015;17(2):214–21.CrossRefPubMed
10.
Higuchi T, Nekolla SG, Huisman MM, Reder S, Poethko T, Yu M, et al. A new 18F-labeled myocardial PET tracer: myocardial uptake after permanent and transient coronary occlusion in rats. J Nucl Med. 2008;49(10):1715–22.CrossRefPubMed
11.
Goorden MC, van der Have F, Kreuger R, Ramakers RM, Vastenhouw B, Burbach JP, et al. VECTor: a preclinical imaging system for simultaneous submillimeter SPECT and PET. J Nucl Med. 2013;54(2):306–12.CrossRefPubMed
12.
Walker MD, Goorden MC, Dinelle K, Ramakers RM, Blinder S, Shirmohammad M, et al. Performance assessment of a preclinical PET scanner with pinhole collimation by comparison to a coincidence-based small-animal PET scanner. J Nucl Med. 2014;55(8):1368–74.CrossRefPubMed
13.
Magota K, Kubo N, Kuge Y, Nishijima K, Zhao S, Tamaki N. Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging. Eur J Nucl Med Mol Imaging. 2011;38(4):742–52.CrossRefPubMed
14.
Spinks TJ, Karia D, Leach MO, Flux G. Quantitative PET and SPECT performance characteristics of the Albira Trimodal pre-clinical tomograph. Phys Med Biol. 2014;59(3):715–31.CrossRefPubMed
15.
Hoffmann JV, Janssen JP, Kanno T, Shibutani T, Onoguchi M, Lapa C, et al. Performance evaluation of fifth-generation ultra-high-resolution SPECT system with two stationary detectors and multi-pinhole imaging. EJNMMI Phys. 2020;7(1):64.CrossRefPubMedPubMedCentral
16.
Miwa K, Inubushi M, Takeuchi Y, Katafuchi T, Koizumi M, Saga T, et al. Performance characteristics of a novel clustered multi-pinhole technology for simultaneous high-resolution SPECT/PET. Ann Nucl Med. 2015;29(5):460–6.CrossRefPubMed
17.
Takahashi Y, Mochiki M, Koyama K, Ino T, Yamaji H, Kawakami A. Evaluation of simultaneous dual-radioisotope SPECT imaging using (18)F-fluorodeoxyglucose and (99m)Tc-tetrofosmin. Asia Ocean J Nucl Med Biol. 2016;4(2):66–71.PubMedPubMedCentral
18.
Slart RH, Bax JJ, van Veldhuisen DJ, van der Wall EE, Irwan R, Sluiter WJ, et al. Prediction of functional recovery after revascularization in patients with chronic ischaemic left ventricular dysfunction: head-to-head comparison between 99mTc-sestamibi/18F-FDG DISA SPECT and 13N-ammonia/ 18F-FDG PET. Eur J Nucl Med Mol Imaging. 2006;33(6):716–23.CrossRefPubMed
19.
Kobayashi M, Matsunari I, Nishi K, Mizutani A, Miyazaki Y, Ogai K, et al. Simultaneous acquisition of (99m)Tc- and (123)I-labeled radiotracers using a preclinical SPECT scanner with CZT detectors. Ann Nucl Med. 2016;30(4):263–71.CrossRefPubMed
20.
Johnson LC, Guerraty MA, Moore SC, Metzler SD. Quantification of myocardial uptake rate constants in dynamic small-animal SPECT using a cardiac phantom. Phys Med Biol. 2019;64(6): 065018.CrossRefPubMedPubMedCentral
21.
Branderhorst W, Vastenhouw B, van der Have F, Blezer EL, Bleeker WK, Beekman FJ. Targeted multi-pinhole SPECT. Eur J Nucl Med Mol Imaging. 2011;38(3):552–61.CrossRefPubMed
22.
Horikawa Y, Onoguchi M, Shibutani T, Kanno T, Mochizuki T, Shiba K. Organ uptake ratio using a small animal SPECT-PET/CT system - comparison with organs removed by rats. Jpn J Nucl Med Technol. 2019;39(suppl):377.
23.
Branderhorst W, Vastenhouw B, Beekman FJ. Pixel-based subsets for rapid multi-pinhole SPECT reconstruction. Phys Med Biol. 2010;55(7):2023–34.CrossRefPubMed
24.
Momose M, Fukushima K, Kondo C, Serizawa N, Suzuki A, Abe K, et al. Diagnosis and detection of myocardial injury in active cardiac sarcoidosis-significance of myocardial fatty acid metabolism and myocardial perfusion mismatch. Circ J. 2015;79(12):2669–76.CrossRefPubMed
25.
Maruyama Y, Masaki N, Shimizu Y, Honda N, Yoshimoto N. Correlation of left ventricular dyssynchrony with myocardial stunning using dual single photon emission computed tomography of 123iodine-beta-methyl iodophenyl pentadecanoic acid and 201thallium scintigraphy after reperfusion therapy. Ann Nucl Med. 2009;23(9):799–805.CrossRefPubMed
Metadaten
Titel
Development of a novel small-animal myocardial phantom can evaluate the image quality of dual-isotope simultaneous acquisition (DISA)
verfasst von
Takayuki Shibutani
Masahisa Onoguchi
Takayuki Kanno
Hiroshi Wakabayashi
Tomo Hiromasa
Seigo Kinuya
Publikationsdatum
13.10.2022
Verlag
Springer Nature Singapore
Erschienen in
Annals of Nuclear Medicine / Ausgabe 12/2022
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-022-01791-z

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