Development of a prognostic oxidative stress-immune-inflammation score and online calculators for predicting survival and recurrence in gastric cancer: a multicenter study
- 06.03.2025
Erschienen in:
- Verfasst von
- Hualong Zheng
- Honghong Zheng
- Xiaoqiang Du
- Binbin Xu
- Minggao Hu
- Junhua Yu
- Rongzhen Xie
- Linghua Wei
- Zhen Xue
- Lili Shen
- Jia Lin
- Jianwei Xie
- Chaohui Zheng
- Changming Huang
- Ping Li
- Erschienen in
- Surgical Endoscopy | Ausgabe 4/2025
Abstract
Background
Oxidative stress, immune response, and inflammation play an important role in the occurrence and progression of gastric cancer (GC). This study is to develop a novel prognostic oxidative stress-immune-inflammation score (POSII score) and to explore the clinical value of the novel nomograms incorporating this factor in survival and recurrence risk.
Methods
This study included 3612 GC patients who underwent radical gastrectomy at three tertiary hospitals from 2009 to 2020. One hospital formed the training and internal validation cohorts, while the other two constituted the external validation cohort. Twelve hematological markers were collected and analyzed to develop the POSII score via LASSO regression. Two online calculators were developed and validated.
Results
The POSII score categorized patients into low and high POSII groups, with the low POSII group showing significantly improved 5-year overall survival (OS) and disease-free survival (DFS) rates, as well as a markedly reduced risk of recurrence (all P < 0.05). Multivariate COX regression showed that the POSII score was an independent prognostic factor. Based on the POSII score, two nomograms (OS: AUC = 0.837; DFS: AUC = 0.834, respectively) for individualized prognostic prediction were constructed. To enhance clinical usability, we further developed two user-friendly online calculators. The high-risk group had an earlier, more persistent peak of recurrence and a high incidence of multiple recurrence patterns.
Conclusion
Two novel online calculators based on the POSII score can be used as reliable tools for predicting survival and recurrence after radical gastrectomy. Our findings provide new insights into the role of cancer-related immune dysregulation, inflammation, and oxidative stress imbalances.
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- Titel
- Development of a prognostic oxidative stress-immune-inflammation score and online calculators for predicting survival and recurrence in gastric cancer: a multicenter study
- Verfasst von
-
Hualong Zheng
Honghong Zheng
Xiaoqiang Du
Binbin Xu
Minggao Hu
Junhua Yu
Rongzhen Xie
Linghua Wei
Zhen Xue
Lili Shen
Jia Lin
Jianwei Xie
Chaohui Zheng
Changming Huang
Ping Li
- Publikationsdatum
- 06.03.2025
- Verlag
- Springer US
- Erschienen in
-
Surgical Endoscopy / Ausgabe 4/2025
Print ISSN: 0930-2794
Elektronische ISSN: 1432-2218 - DOI
- https://doi.org/10.1007/s00464-025-11596-6
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