Background
Methods
Rapid knee cartilage damage index quantification method
Validation dataset
MR image assessments
Measurement of cartilage damage on MR images
Assessment of reliability
Assessment of measurement time
Radiographic assessments
Static alignment
Analytic approach
Results
Validation dataset characteristics
Age, mean (SD) years | 61.61 (8.74) | |
---|---|---|
Female, n (%)
| 56 (54.37) | |
JSN grade, n (%)
|
Baseline
|
24-month follow-up
|
0
| 43 (42.16) | 42 (41.18) |
1
| 31 (30.39) | 25 (24.51) |
2
| 25 (24.51) | 20 (19.61) |
3
| 3 (2.94) | 15 (14.71) |
KL score, n (%)
|
Baseline
|
24-month follow-up
|
0
| 4 (3.92) | 3 (2.94) |
1
| 19 (18.63) | 15 (14.71) |
2
| 40 (39.22) | 25 (24.51) |
3
| 34 (33.33) | 40 (39.22) |
4
| 5 (4.90) | 19 (18.63) |
Measurement time
Assessment of reliability
Relationship of baseline CDI to baseline radiographic severity
Medial JSN
Baseline medial JSN Grade | |||||
---|---|---|---|---|---|
Cartilage measure | JSN = 0 (n = 43) mean (SD) | JSN = 1 (n = 31) mean (SD) | JSN = 2 (n = 25) mean (SD) | JSN = 3 (n = 3) mean (SD) | p-value for trend |
Cross-sectional
| |||||
Femur CDI (Baseline)
| 825.14 (148.42) | 754.71 (125.54) | 529.29 (130.35) | 325.89 (324.51) | <0.01 |
Tibia CDI (Baseline)
| 352.29 (72.47) | 328.96 (60.91) | 233.45 (68.77) | 95.83 (99.73) | <0.01 |
Tibiofemoral CDI (Baseline)
| 1177.40 (198.78) | 1083.70 (173.17) | 762.74 (183.50) | 421.72 (420.65) | <0.01 |
Longitudinal
| |||||
Femur CDI (Change)
| −31.06 (46.40) | −49.67 (61.65) | −78.55 (66.81) | −185.4 (170.07) | <0.01 |
Tibia CDI (Change)
| −12.17 (25.16) | −23.27 (33.83) | −46.18 (52.46) | −42.41 (41.07) | <0.01 |
Tibiofemoral CDI (Change)
| −43.23 (57.65) | −72.94 (76.02) | −124.70 (97.47) | −227.80 (208.59) | <0.01 |
JSW measurement
Spearman correlation | ||
---|---|---|
HKA
|
JSW baseline
| |
Femur CDI (Baseline)
| 0.34* | 0.84* |
Tibia CDI (Baseline)
| 0.21* | 0.77* |
Tibiofemoral CDI (Baseline)
| 0.31* | 0.87* |
HKA JSW change
| ||
Femur CDI (Change)
| 0.29* | 0.30* |
Tibia CDI (Change)
| 0.34* | 0.40* |
Tibiofemoral CDI (Change)
| 0.36* | 0.43* |
KL grade
Cartilage measure | KL = 0 (n = 4) mean (SD) | KL = 1 (n = 19) mean (SD) | KL = 2 (n = 40) mean (SD) | KL = 3 (n = 34) mean (SD) | KL = 4 (n = 5) mean (SD) | p-value for trend |
---|---|---|---|---|---|---|
Cross-sectional
| ||||||
Femur CDI (Baseline)
| 771.99 (157.40) | 750.75 (159.50) | 781.47 (114.73) | 634.00 (218.90) | 583.92 (434.01) | <0.01 |
Tibia CDI (Baseline)
| 363.07 (103.74) | 314.96 (60.46) | 343.96 (66.72) | 272.83 (94.26) | 199.81 (163.56) | <0.01 |
Tibiofemoral CDI (Baseline)
| 1135.1 (257.41) | 1065.7 (207.06) | 1125.4 (155.11) | 906.83 (304.59) | 783.73 (595.54) | <0.01 |
Longitudinal
| ||||||
Femur CDI (Change)
| −81.06 (46.06) | −30.35 (43.25) | −36.72 (59.38) | −72.92 (62.13) | −109.4 (159.37) | 0.02 |
Tibia CDI (Change)
| −56.37 (43.48) | −17.85 (32.13) | −15.14 (26.74) | −35.36 (49.33) | −30.86 (33.75) | 0.40 |
Tibiofemoral CDI (Change)
| −137.40 (80.56) | −48.19 (61.81) | −51.86 (69.27) | −108.30 (90.93) | −140.20 (190.81) | 0.03 |
Knee alignment
Relationship of longitudinal change in CDI to baseline radiographic severity
Medial JSN
KL grade
Knee alignment
Relationship of longitudinal change in CDI to longitudinal change in radiographic severity
Medial JSN and KL grades
Joint Space Narrowing (JSN) | |||||||||
---|---|---|---|---|---|---|---|---|---|
No structural progression | Structural progression | p-value | |||||||
n | Mean | SD | SRM | n | Mean | SD | SRM | ||
Femur CDI (Change)
| 74 | −35.73 | 50.14 | −0.71 | 25 | −87.82 | 68.62 | −1.28 | <0.0001 |
Tibia CDI (Change)
| 74 | −10.86 | 23.99 | −0.45 | 25 | −63.83 | 46.02 | −1.39 | <0.0001 |
Tibiofemoral CDI (Change)
| 74 | −46.58 | 57.48 | −0.81 | 25 | −151.7 | 90.95 | −1.67 | <0.0001 |
Kellgren-Lawrence
(KL)
| |||||||||
No structural progression
|
Structural progression
|
p-value
| |||||||
n
|
Mean
|
SD
|
SRM
|
n
|
Mean
|
SD
|
SRM
| ||
Femur CDI (Change)
| 58 | −40.53 | 49.84 | −0.81 | 39 | −64.06 | 70.06 | −0.91 | 0.060 |
Tibia CDI (Change)
| 58 | −15.86 | 33.21 | −0.48 | 39 | −37.23 | 43.34 | −0.86 | 0.007 |
Tibiofemoral CDI (Change)
| 58 | −56.39 | 64.12 | −0.88 | 39 | −101.3 | 96.68 | −1.05 | 0.007 |