Erschienen in:
01.05.2008 | Oral presentation
Development of breast cancer immunotherapy using MUC1-retargeted T lymphocytes
verfasst von:
S Wilkie, G Picco, J Foster, D Davies, S Julien, L Cooper, S Arif, S Mather, J Taylor-Papadimitriou, J Burchell, J Maher
Erschienen in:
Breast Cancer Research
|
Sonderheft 2/2008
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Excerpt
MUC1 is a highly attractive target for immunotherapy of breast cancer owing to its overexpression, altered glycosylation and loss of polarity in over 90% of tumours. To exploit this, we are developing genetic approaches to retarget T-cell specificity to MUC1 using chimeric antigen receptor (CAR) technology. …