The online version of this article (doi:10.1186/1475-2840-11-76) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
FN carried out the data analysis and drafted the manuscript. QQ participated in the concept design, funding and coordination of the study and in drafting the manuscript. AO, CDAS, JMD, JSY, JT, KP, LZ and TL contributed to data collection, discussion and approved the final version of the manuscript.
Individuals who had normoglycemia but whose 2-hour plasma glucose (2hPG) concentrations did not return to the fasting plasma glucose (FPG) levels during an oral glucose tolerance test (OGTT) have been shown to have increased cardiovascular mortality. This is further investigated regarding to the first events of coronary heart disease (CHD) and ischemic stroke (IS).
Data from 9 Finnish and Swedish cohorts comprising 3743 men and 3916 women aged 25 to 90 years who had FPG < 6.1 mmol/l and 2hPG < 7.8 mmol/l and free of CVD at enrolment were analyzed. Hazard ratios (HRs) for first CHD and IS events were estimated for the individuals with 2hPG > FPG (Group II) compared with those having 2hPG ≤ FPG (Group I).
A total of 466 (115) CHD and 235 (106) IS events occurred in men (women) during a median follow-up of 16.4 years. Individuals in Group II were older and had greater body mass index, blood pressure, 2hPG and fasting insulin than those in Group I in both sexes. Multivariate adjusted HRs (95% confidence intervals) for incidence of CHD, IS, and composite CVD events (CHD + IS) in men were 1.13 (0.93-1.37), 1.40 (1.06-1.85) and 1.20 (1.01-1.42) in the Group II as compared with those in the Group I. The corresponding HRs in women were 1.33 (0.83-2.13), 0.94 (0.59-1.51) and 1.11 (0.79-1.54), respectively.
Within normoglycemic range individuals whose 2hPG did not return to their FPG levels during an OGTT had increased risk of CHD and IS.
Authors’ original file for figure 112933_2012_485_MOESM1_ESM.pdf
Doi Y, Ninomiya T, Hata J, Fukuhara M, Yonemoto K, Iwase M, Iida M, Kiyohara Y: Impact of glucose tolerance status on development of ischemic stroke and coronary heart disease in a general Japanese population: the Hisayama Study. Stroke. 2010, 41: 203-209. 10.1161/STROKEAHA.109.564708. CrossRefPubMed
Fujishima M, Kiyohara Y, Kato I, Ohmura T, Iwamoto H, Nakayama K, Ohmori S, Yoshitake T: Diabetes and cardiovascular disease in a prospective population survey in Japan: the Hisayama Study. Diabetes. 1996, 45 (Suppl 3): 14S-16S. CrossRef
Barr EL, Boyko EJ, Zimmet PZ, Wolfe R, Tonkin AM, Shaw JE: Continuous relationships between non-diabetic hyperglycaemia and both cardiovascular disease and all-cause mortality: the Australian Diabetes, Obesity, and Lifestyle (AusDiab) study. Diabetologia. 2009, 52: 415-424. 10.1007/s00125-008-1246-y. CrossRefPubMed
Smith NL, Barzilay JI, Shaffer D, Savage PJ, Heckbert SR, Kuller LH, Kronmal RA, Resnick HE, Psaty BM: Fasting and 2-hour postchallenge serum glucose measures and risk of incident cardiovascular events in the elderly: the cardiovascular health study. Arch Intern Med. 2002, 162: 209-216. 10.1001/archinte.162.2.209. CrossRefPubMed
DECODE study group: Glucose tolerance and mortality: comparison of WHO and American Diabetes Association diagnostic criteria. DECODE Study Group on behalf of the European Diabetes Epidemiology Study Group. Lancet. 1999, 354: 617-621. CrossRef
DECODE study group: Glucose tolerance and cardiovascular mortality: comparison of fasting and 2-hour diagnostic criteria. DECODE Study Group on behalf of the European Diabetes Epidemiology Study Group. Arch Intern Med. 2001, 161: 397-405. 10.1001/archinte.161.3.397. CrossRef
DECODE study group: Will new diagnostic criteria for diabetes mellitus change phenotype of patients with diabetes? Reanalysis of European epidemiological data. DECODE Study Group on behalf of the European Diabetes Epidemiology Study Group. BMJ. 1998, 317: 371-375. 10.1136/bmj.317.7155.371. CrossRef
DECODE study group: Is fasting glucose sufficient to define diabetes? Epidemiological data from 20 European studies. European Diabetes Epidemiology Group. Diabetes Epidemiology: Collaborative analysis of Diagnostic Criteria in Europe. Diabetologia. 1999, 42: 647-654. 10.1007/s001250051211. CrossRef
World Health Organization: World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension. Guidelines Subcommittee. J Hypertens. 1999, 1999 (17): 151-183.
World Health Organization and International Diabetes Federation Consultation: Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia: report of a WHO/IDF consultation. 2006, Geneva: World Health Organization
Mahonen M, Salomaa V, Keskimaki I, Moltchanov V, Torppa J, Molarius A, Tuomilehto J, Sarti C, FINMONICA Stroke Register Study group: The feasibility of combining data from routine Hospital Discharge and Causes-of-Death Registers for epidemiological studies on stroke. Eur J Epidemiol. 2000, 16: 815-817. 10.1023/A:1007697720131. CrossRefPubMed
Pajunen P, Koukkunen H, Ketonen M, Jerkkola T, Immonen-Raiha P, Karja-Koskenkari P, Mahonen M, Niemela M, Kuulasmaa K, Palomaki P, Mustonen J, Lehtonen A, Arstila M, Vuorenmaa T, Lehto S, Miettinen H, Torppa J, Tuomilehto J, Kesaniemi YA, Pyorala K, Salomaa V: The validity of the Finnish Hospital Discharge Register and Causes of Death Register data on coronary heart disease. Eur J Cardiovasc Prev Rehabil. 2005, 12: 132-137. PubMed
Schinner S, Futh R, Kempf K, Martin S, Willenberg HS, Schott M, Dinh W, Scherbaum WA, Lankisch M: A progressive increase in cardiovascular risk assessed by coronary angiography in non-diabetic patients at sub-diabetic glucose levels. Cardiovasc Diabetol. 2011, 10: 56-10.1186/1475-2840-10-56. PubMedCentralCrossRefPubMed
Jia Q, Zheng H, Zhao X, Wang C, Liu G, Wang Y, Liu L, Li H, Zhong L, Wang Y, Investigators for the Survey on Abnormal Glucose Regulation in Patients With Acute Stroke Across China (ACROSS-China): Abnormal glucose regulation in patients with acute stroke across China: prevalence and baseline patient characteristics. Stroke. 2012, 43: 650-657. 10.1161/STROKEAHA.111.633784. CrossRefPubMed
Laakso M, Zilinskaite J, Hansen T, Boesgaard TW, Vanttinen M, Stancakova A, Jansson PA, Pellme F, Holst JJ, Kuulasmaa T, Hribal ML, Sesti G, Stefan N, Fritsche A, Haring H, Pedersen O, Smith U, EUGENE2 Consortium: Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study. Diabetologia. 2008, 51: 502-511. 10.1007/s00125-007-0899-2. CrossRefPubMed
Succurro E, Marini MA, Grembiale A, Lugara M, Andreozzi F, Sciacqua A, Hribal ML, Lauro R, Perticone F, Sesti G: Differences in cardiovascular risk profile based on relationship between post-load plasma glucose and fasting plasma levels. Diabetes Metab Res Rev. 2009, 25: 351-356. 10.1002/dmrr.951. CrossRefPubMed
Kahn SE: The importance of beta-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab. 2001, 86: 4047-4058. 10.1210/jc.86.9.4047. PubMed
Balletshofer BM, Rittig K, Enderle MD, Volk A, Maerker E, Jacob S, Matthaei S, Rett K, Haring HU: Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance. Circulation. 2000, 101: 1780-1784. 10.1161/01.CIR.101.15.1780. CrossRefPubMed
Yudkin JS, Stehouwer CDA, Emeis JJ, Coppack SW: C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?. Arterioscler Thromb Vasc Biol. 1999, 19: 972-978. 10.1161/01.ATV.19.4.972. CrossRefPubMed
- Development of coronary heart disease and ischemic stroke in relation to fasting and 2-hour plasma glucose levels in the normal range
Jacqueline M Dekker
Coen DA Stehouwer
John S Yudkin
DECODE Finnish and Swedish Study Investigators
- BioMed Central
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