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12.10.2023 | Original Article

Development of gel containing Psidium glaziovianum essential oil has in vitro antimicrobial activity and improves healing of excisional wounds in mice

verfasst von: Wêndeo Kennedy Costa, Valquíria Bruna Guimarães, Beatriz Meyruze Barros da Fonsêca, Magda Rhayanny Assunção Ferreira, Luiz Alberto Lira Soares, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva, Maria Tereza dos Santos Correia, Fábio André Brayner dos Santos, Alisson Macário de Oliveira, Márcia Vanusa da Silva

Erschienen in: Inflammopharmacology

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Abstract

Wounds encompass physical, chemical, biological, induced damages to the skin or mucous membranes. In wound treatment, combating infections is a critical challenge due to their potential to impede recovery and inflict systemic harm on patients. Previously, the essential oil extracted from Psidium glaziovianum (PgEO) demonstrated antinociceptive and anti-inflammatory attributes, along with negligible oral toxicity. Hence, our study aimed to assess the effects of topically applying a gel formulation containing PgEO to excisional wounds in mice. Additionally, an in vitro antimicrobial assessment was conducted. The formulated gel underwent characterization and toxicological evaluation on erythrocytes, as well as a dermal irritation test. Its antimicrobial activity was tested against both gram-positive and gram-negative bacteria, as well as fungi. Subsequently, an assessment of its efficacy in excisional wound healing was conducted in mice. The findings of this investigation highlight the gel's efficacy against both gram-positive and gram-negative bacteria, as well as fungi. Moreover, this study underscores that the PgEO-gel treatment enhances skin wound healing, potentially due to its capacity to trigger antioxidant enzymes and suppress pro-inflammatory cytokines. Furthermore, the gel exhibited minimal toxicity to erythrocytes and skin irritation. These findings hold promise for prospective preclinical and clinical trials across diverse wound types. In conclusion, this study sheds light on the potential therapeutic applications of the gel formulation containing essential oil from P. glaziovianum in the context of wound healing.
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Metadaten
Titel
Development of gel containing Psidium glaziovianum essential oil has in vitro antimicrobial activity and improves healing of excisional wounds in mice
verfasst von
Wêndeo Kennedy Costa
Valquíria Bruna Guimarães
Beatriz Meyruze Barros da Fonsêca
Magda Rhayanny Assunção Ferreira
Luiz Alberto Lira Soares
Thiago Henrique Napoleão
Patrícia Maria Guedes Paiva
Maria Tereza dos Santos Correia
Fábio André Brayner dos Santos
Alisson Macário de Oliveira
Márcia Vanusa da Silva
Publikationsdatum
12.10.2023
Verlag
Springer International Publishing
Erschienen in
Inflammopharmacology
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-023-01351-5