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Erschienen in: European Radiology 9/2016

24.02.2016 | Contrast Media

Development of silica-encapsulated silver nanoparticles as contrast agents intended for dual-energy mammography

verfasst von: Roshan Karunamuni, Pratap C. Naha, Kristen C. Lau, Ajlan Al-Zaki, Anatoliy V. Popov, Edward J. Delikatny, Andrew Tsourkas, David P. Cormode, Andrew D. A. Maidment

Erschienen in: European Radiology | Ausgabe 9/2016

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Abstract

Objective

Dual-energy (DE) mammography has recently entered the clinic. Previous theoretical and phantom studies demonstrated that silver provides greater contrast than iodine for this technique. Our objective was to characterize and evaluate in vivo a prototype silver contrast agent ultimately intended for DE mammography.

Methods

The prototype silver contrast agent was synthesized using a three-step process: synthesis of a silver core, silica encapsulation and PEG coating. The nanoparticles were then injected into mice to determine their accumulation in various organs, blood half-life and dual-energy contrast. All animal procedures were approved by the institutional animal care and use committee.

Results

The final diameter of the nanoparticles was measured to be 102 (±9) nm. The particles were removed from the vascular circulation with a half-life of 15 min, and accumulated in macrophage-rich organs such as the liver, spleen and lymph nodes. Dual-energy subtraction techniques increased the signal difference-to-noise ratio of the particles by as much as a factor of 15.2 compared to the single-energy images. These nanoparticles produced no adverse effects in mice.

Conclusion

Silver nanoparticles are an effective contrast agent for dual-energy x-ray imaging. With further design improvements, silver nanoparticles may prove valuable in breast cancer screening and diagnosis.

Key Points

Silver has potential as a contrast agent for DE mammography.
Silica-coated silver nanoparticles are biocompatible and suited for in vivo use.
Silver nanoparticles produce strong contrast in vivo using DE mammography imaging systems.
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Metadaten
Titel
Development of silica-encapsulated silver nanoparticles as contrast agents intended for dual-energy mammography
verfasst von
Roshan Karunamuni
Pratap C. Naha
Kristen C. Lau
Ajlan Al-Zaki
Anatoliy V. Popov
Edward J. Delikatny
Andrew Tsourkas
David P. Cormode
Andrew D. A. Maidment
Publikationsdatum
24.02.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 9/2016
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-4152-y

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