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Breast Cancer Research

Erschienen in:

01.10.2009 | Editorial

Development of 'synthetic lethal' strategies to target BRCA1-deficient breast cancer

verfasst von: Max S Wicha

Erschienen in: Breast Cancer Research | Ausgabe 5/2009

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Abstract

Recent clinical trials demonstrating the efficacy of poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of BRCA1-deficient breast cancer have provided support for the 'synthetic lethal' concept of targeted cancer therapeutics. A new study provides further preclinical validation of this concept by demonstrating that BRCA1-deficient mouse mammary tumor cells are selectively sensitive to an inhibitor of the polycomb gene EZH2. The development of polycomb gene inhibitors may provide a novel approach to selectively exploit the molecular alterations in BRCA1-deficient breast tumors.

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Titel: Development of 'synthetic lethal' strategies to target BRCA1-deficient breast cancer
verfasst von: Max S Wicha
Publikationsdatum: 01.10.2009
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 5/2009
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr2362

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Development of 'synthetic lethal' strategies to target BRCA1-deficient breast cancer

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