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Erschienen in: Der Anaesthesist 12/2012

01.12.2012 | Klinische Pharmakologie

Dexmedetomidin

Pharmakokinetik und Pharmakodynamik

verfasst von: Dr. H. Ihmsen, T.I. Saari

Erschienen in: Die Anaesthesiologie | Ausgabe 12/2012

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Zusammenfassung

Mit Dexmedetomidin ist 2011 ein potenter selektiver α2-Adrenozeptor-Agonist zur Sedierung erwachsener, intensivmedizinisch behandelter Patienten neu auf dem europäischen Markt zugelassen worden. Dexmedetomidin zeigt konzentrationsabhängig sowohl sedierende als auch analgetische und anxiolytische Wirkungen. Aktuelle Studien lassen Dexmedetomidin als eine Alternative zu Midazolam für die Langzeitsedierung erscheinen. In dieser Übersichtsarbeit werden die pharmakokinetischen und pharmakodynamischen Eigenschaften von Dexmedetomidin insbesondere bei intensivmedizinischen Patienten, unter besonderer Berücksichtigung des Einflusses von Kovariaten, zusammengefasst. Obwohl Dexmedetomidin nur für Erwachsene zugelassen ist und die Anwendung bei Kindern daher einem „off label use“ entspricht, wird auch auf die Pharmakokinetik und -dynamik bei Kindern eingegangen, da dazu ebenfalls zahlreiche Studien vorliegen.
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Metadaten
Titel
Dexmedetomidin
Pharmakokinetik und Pharmakodynamik
verfasst von
Dr. H. Ihmsen
T.I. Saari
Publikationsdatum
01.12.2012
Verlag
Springer Berlin Heidelberg
Erschienen in
Die Anaesthesiologie / Ausgabe 12/2012
Print ISSN: 2731-6858
Elektronische ISSN: 2731-6866
DOI
https://doi.org/10.1007/s00101-012-2114-1

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