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27.06.2024 | Note

Di-caffeoylquinic acid: a potential inhibitor for amyloid-beta aggregation

verfasst von: Yue Sun, Xue Wang, Xiaoyu Zhang, Yan Li, Dongdong Wang, Feng Sun, Cunli Wang, Zhenqiang Shi, Xindi Yang, Zhiying Yang, Haijie Wei, Yanling Song, Guangyan Qing

Erschienen in: Journal of Natural Medicines | Ausgabe 4/2024

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Abstract

Alzheimer's disease (AD) remains a challenging neurodegenerative disorder with limited therapeutic success. Traditional Chinese Medicine (TCM), as a promising new source for AD, still requires further exploration to understand its complex components and mechanisms. Here, focused on addressing Aβ (1–40) aggregation, a hallmark of AD pathology, we employed a Thioflavin T fluorescence labeling method for screening the active molecular library of TCM which we established. Among the eight identified, 1,3-di-caffeoylquinic acid emerged as the most promising, exhibiting a robust binding affinity with a KD value of 26.7 nM. This study delves into the molecular intricacies by utilizing advanced techniques, including two-dimensional (2D) ¹⁵N-¹H heteronuclear single quantum coherence nuclear magnetic resonance (NMR) and molecular docking simulations. These analyses revealed that 1,3-di-caffeoylquinic acid disrupts Aβ (1–40) self-aggregation by interacting with specific phenolic hydroxyl and amino acid residues, particularly at Met-35 in Aβ (1–40). Furthermore, at the cellular level, the identified compounds, especially 1,3-di-caffeoylquinic acid, demonstrated low toxicity and exhibited therapeutic potential by regulating mitochondrial membrane potential, reducing cell apoptosis, and mitigating Aβ (1–40)-induced cellular damage. This study presents a targeted exploration of catechol compounds with implications for effective interventions in AD and sheds light on the intricate molecular mechanisms underlying Aβ (1–40) aggregation disruption.

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Titel: Di-caffeoylquinic acid: a potential inhibitor for amyloid-beta aggregation
verfasst von: Yue Sun
Xue Wang
Xiaoyu Zhang
Yan Li
Dongdong Wang
Feng Sun
Cunli Wang
Zhenqiang Shi
Xindi Yang
Zhiying Yang
Haijie Wei
Yanling Song
Guangyan Qing
Publikationsdatum: 27.06.2024
Verlag: Springer Nature Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 4/2024
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-024-01825-y

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Di-caffeoylquinic acid: a potential inhibitor for amyloid-beta aggregation

Abstract

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